The Effects Of Cerebellar Stimulation On the Averaged Sensory Evoked Responses in the Cat

Boone, Stephen C.; Nashold, Blaine S.; Wilson, Wilkie A.

doi:10.1007/978-1-4613-4508-4_11

Cited by 4 publications

(4 citation statements)

References 9 publications

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“…Although further studies are re : quired, the difference between our results in man and the results of Boone et al (1973) in cats may be attributable to species differences.…”

Section: Visual Evoked Potentialscontrasting

confidence: 59%

“…We were unable to demonstrate any effects of cerebellar stimulation on the visual evoked potentials after flash stimulation but stimulation of cerebellar cortex has been shown to inhibit cerebral photic evoked responses in rats (Dow et al, 1962) and cats (Boone et al, 1973) Boone et al (1973 showed that lower voltages of stimulation (e.g. 2.0 volts) produced ipsilateral inhibition with partial contralateral inhibition of flash evoked cortical responses, whereas complete bilateral inhibition occurred at four volts.…”

Section: Visual Evoked Potentialsmentioning

confidence: 57%

“…One further problem was that movement and irregular muscular contractions could not be eliminated in the spastic and athetoid patients and we found it necessary to adjust the preamplifier to reduce the amplitude of potentials by 3dB at 50 Hz. Boone et al, (1973) thought that cerebellar inhibition of evoked potentials acted through the fastigial pathways since they found predominantly ipsilateral effects on cerebral evoked potentials in the cat whereas in man we have observed predominantly contralateral effects which may involve the dentate or interpositus nuclei. There were some ipsilateral effects of cerebellar stimulation in 10 patients but these were always less than the contralateral effects.…”

Section: Bm Mmentioning

confidence: 61%

“…Of interest is the fact that intravenous sodium pentobarbital (30 mg/kg) has been shown to completely prevent cerebellar inhibition of photic evoked responses in the visual cortex and lateral geniculate body of the cat (Boone et al, 1973 Serial somatosensory evoked potentials (SSEPs) from both hemispheres are seen after left (left side of picture) and right (right side of picture) anterior cerebellar stimulation. The left median nerve was stimulated every two seconds and each tracing represents an average of 64 potentials.…”

Section: Effects Of Diph Enylhydan Toin (Dph) Therapymentioning

confidence: 99%

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Some Neurophysiological Effects of Cerebellar Stimulation in Man

Upton

Cooper

1976

Can. j. neurol. sci.

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SUMMARY:This paper presents the results of neurophysiological studies of the effects of cerebellar stimulation on H reflexes, late reflexes, blink reflexes, evoked potentials and EEG patterns in 18 human subjects (Male 13, Female 5, Age 25.8 ±10.0, Epileptic 9, Cerebral Palsy 9).In addition to the effects of cerebellar stimulation on the H reflex studies on salens we assessed V1 and V2, “late” responses (Upton et al., 1971), cortical somatosensory evoked potentials (SSEP) after median nerve stimulation, and visual evoked responses (VER) after flash stimulation. Experiments were extended to assess recovery curves of all the potentials and we examined the effects of changes on the rate or voltage of cerebellar stimulation.Cerebellar stimulation was inhibitory to all the responses except the visual evoked potentials. Serial studies in five patients produced consistent results. Preoperative and postoperative results were compared in two patients with no significant difference in the results in the absence of cerebellar stimulation.Ipsilateral cerebellar stimulation (CS) had the greatest inhibitory effects on H, V1 and V2 responses in the arm and leg whereas contralateral CS produced the greatest effects on cortical SSEPs. There was a greater bilateral effect on SSEPs and reflex responses after right CS than left CS and this may be the first indication of “dominance” in the cerebellar hemispheres. Cerebellar stimulation in patients on diphenylhydantoin produced minimal effects on SSEP“s and this observation has led to further studies in patients taking diphenylhydantoin.Recovery of amplitude of the reflex and cortical responses took eight to 30 minutes after one minute of cerebellar stimulation. Serial CS of one minute on and one minute off produced increasing inhibition of SSEP's and reflexes for up to five stimulations. Recovery after cessation of cerebellar stimullion was associated with rebound excitation in six patients, the rebound being noted in the amplitude of H reflexes and SSEP's as well as in the frequency of paroxysmal spike and wave discharges in the EEG.The correlation of the results of such quantitative neurophysiological tests with clinical improvement may allow prediction of clinical results after cerebellar stimulation. These techniques have already been used to measure the threshold of stimulation and may allow optimal stimulation characteristics to be assessed. The prolonged neurophysiological effects of stimulation may allow the use of maximum effective intervals between optimal epochs of stimulation so that any cerebellar damage can be minimized.

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“…Although further studies are re : quired, the difference between our results in man and the results of Boone et al (1973) in cats may be attributable to species differences.…”

Section: Visual Evoked Potentialscontrasting

confidence: 59%

Section: Visual Evoked Potentialsmentioning

confidence: 57%

Section: Bm Mmentioning

confidence: 61%

Section: Effects Of Diph Enylhydan Toin (Dph) Therapymentioning

confidence: 99%

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Some Neurophysiological Effects of Cerebellar Stimulation in Man

Upton

Cooper

1976

Can. j. neurol. sci.

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Absence of cerebellar influences on hippocampal neurons in the cat

Crow

Finch

Babb

1977

Experimental Neurology

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Cerebellar Stimulation in Alumina‐Gel Monkey Model: Inverse Relationship Between Clinical Seizures and EEG Interictal Bursts

et al. 1979

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The efficacy of cerebellar stimulation was addressed in a chronic monkey model (N = 12) of spontaneous focal motor and secondarily generalized seizures using 24 hr seizure frequency monitoring and all-night EEG recording. The anterior cerebellar vermis was stimulated employing parameters similar to those used in man, 10 Hz, 1 msec pulses, 10 min on, 10 off, at an average current of 2.0 mA. Six weeks pre- and post-base-line periods were compared to a stimulation period of the same length. The results contribute to a clarification of conflicting findings of previous researchers by revealing an inverse relationship between seizure frequency and interictal EEG bursts during the weeks of stimulation. Seizure frequency increased significantly and interictal bursts decreased. Both of these effects (especially the former) were evident in the post-stimulation period, but for different reasons than hypothesized for the period of stimulation. Whereas the therapeutic value of cerebellar stimulation on seizures may be in question, its utilization in the study of mechanisms of epilepsy may be warranted.

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The Effects Of Cerebellar Stimulation On the Averaged Sensory Evoked Responses in the Cat

Cited by 4 publications

References 9 publications

Some Neurophysiological Effects of Cerebellar Stimulation in Man

Some Neurophysiological Effects of Cerebellar Stimulation in Man

Absence of cerebellar influences on hippocampal neurons in the cat

Cerebellar Stimulation in Alumina‐Gel Monkey Model: Inverse Relationship Between Clinical Seizures and EEG Interictal Bursts

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