The effects of cetirizine on the function of inflammatory cells involved in the allergic response

Walsh, Garry Michael

doi:10.1111/j.1365-2222.1997.tb02583.x

Cited by 15 publications

(8 citation statements)

References 37 publications

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“…[40][41][42] It has, by far, the most documented antiallergic effects independent of its antihistaminic effects at approved dosages. 43 It has been shown to decrease eosinophilic infiltration of the skin 44,45 and diminish the late phase response. 44 -46 It is approved for use by children as young as 6 months old.…”

Section: Cetirizine (Zyrtec)mentioning

confidence: 99%

New Oral Antihistamines in Pediatrics

Horowitz¹,

Reynolds²

2004

Pediatric Emergency Care

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This CME activity is intended for physicians, medical students, nurse practitioners, and physician assistants who manage children with acute illness in either the emergency department (ED) or office-based settings. Pediatric emergency physicians, emergency physicians, pediatricians, and family practitioners will find this information especially useful. LEARNING OBJECTIVESAfter completion of the article, the reader should be able to: 1. Discuss the role histamine plays in allergic responses. 2. Describe differences between first-and second-generation antihistamines based on pharmacology and side effect profiles. 3. Identify the second-generation antihistamines and their relative strengths and weaknesses.

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Section: Cetirizine (Zyrtec)mentioning

confidence: 99%

New Oral Antihistamines in Pediatrics

Horowitz¹,

Reynolds²

2004

Pediatric Emergency Care

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“…Furthermore, the skin window technique enumerates and identifies cells that have undergone transendothelial migration and so have left the dermal postcapillary venules, whereas a biopsy measures the gross cellular content at the reaction site. This is a potentially important difference since cetirizine may exert its effect by inhibiting eosinophil adhesion to and/or transendothelial migration across the microvascular endothelium (34). However, two other studies that utilized the skin window technique failed to demonstrate significant inhibition of allergen-induced, late-phase, cutaneous allergic inflammatory cell accumulation following cetirizine treatment (35,36).…”

Section: Antihistamines: Anti-inflammatory Effects In Vivomentioning

confidence: 99%

The anti-inflammatory effects of the second-generation antihistamines

Walsh¹

2000

Dermatol Ther

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Second-generation histamines are widely used and effective drugs for the treatment of urticaria, atopic dermatitis, and in both seasonal and perennial allergic rhinitis. It has been recognized for some years that the newer antihistamines have a number of additional anti-inflammatory effects which appear to be independent of their H 1 receptor antagonist effect. These include in vitro inhibitory effects on eosinophil activation, chemotaxis, and on platelet, lymphocyte, or neutrophil activation, while in vivo several researchers have documented protective effects on the changes induced by skin prick test with histamine or allergen, in the specific nasal provocation test, and also limited protection to the specific bronchial provocation test. Other effects are inhibition of the accumulation of proinflammatory cells at allergen-challenged skin sites and downregulation of allergen-induced expression of the adhesion molecule ICAM-1 by epithelial cells. These additional properties may enhance the effects of these drugs in the treatment of allergic disease.

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“…Although the ability of antihistamines to exert antiallergic effects in man has been appreciated for some time (16), the question of whether this enhances their therapeutic benefit has been the subject of much debate. Of the currently available second‐generation antihistamines, it appears that cetirizine has by far the most documented antiallergic effects (17). Recent studies suggest that cetirizine may be effective in diminishing the late‐phase reaction (18–20).…”

Section: Comprehensivenessmentioning

confidence: 99%

The clinical efficacy of antihistamines in the skin

Tharp¹

2000

Allergy

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The effects of cetirizine on the function of inflammatory cells involved in the allergic response

Cited by 15 publications

References 37 publications

New Oral Antihistamines in Pediatrics

New Oral Antihistamines in Pediatrics

The anti-inflammatory effects of the second-generation antihistamines

The clinical efficacy of antihistamines in the skin

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