The effects of chemotherapy on energy metabolic aspects in cancer patients: A systematic review

Soom, Timia Van; Bakkali, Samera El; Gebruers, Nick; Verbelen, Hanne; Tjalma, Wiebren A.A.; Breda, Eric van

doi:10.1016/j.clnu.2019.07.028

Cited by 40 publications

(27 citation statements)

References 60 publications

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“…It has been suggested that the increased energy expenditure at the end of therapy is related to stress caused by the cumulative effects of chemoradiotherapy 212 . A systematic review of the literature on energy metabolism in patients who received chemotherapy for all cancer types showed no universal impact of chemotherapy on energy expenditure but suggested that patients receiving chemotherapy become hypometabolic during treatment 213 . Most studies have used indirect calorimetry, anthropometry, and routine laboratory tests to assess metabolic status.…”

Section: Metabolism In Tumors and Patients With Cancermentioning

confidence: 99%

Metabolomics in cancer research and emerging applications in clinical oncology

Schmidt

Patel

Kirsch

et al. 2021

CA A Cancer J Clinicians

411

271

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Cancer has myriad effects on metabolism that include both rewiring of intracellular metabolism to enable cancer cells to proliferate inappropriately and adapt to the tumor microenvironment, and changes in normal tissue metabolism. With the recognition that fluorodeoxyglucose-positron emission tomography imaging is an important tool for the management of many cancers, other metabolites in biological samples have been in the spotlight for cancer diagnosis, monitoring, and therapy. Metabolomics is the global analysis of small molecule metabolites that like other -omics technologies can provide critical information about the cancer state that are otherwise not apparent. Here, the authors review how cancer and cancer therapies interact with metabolism at the cellular and systemic levels. An overview of metabolomics is provided with a focus on currently available technologies and how they have been applied in the clinical and translational research setting. The authors also discuss how metabolomics could be further leveraged in the future to improve the management of patients with cancer.

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Section: Metabolism In Tumors and Patients With Cancermentioning

confidence: 99%

Metabolomics in cancer research and emerging applications in clinical oncology

Schmidt

Patel

Kirsch

et al. 2021

CA A Cancer J Clinicians

411

271

View full text Add to dashboard Cite

show abstract

“…Among the treatment modalities to breast cancer, neoadjuvant chemotherapy, the modality of chemotherapy that occurs before surgical procedures, is performed with the objective of improving conditions for tumor resection and prognostic results, decreasing the risk of local recurrence [3]. However, this systemic therapeutic modality can impair nutritional status [4,5], by reducing food intake due to the higher occurrence of gastrointestinal toxicities including nausea and vomiting [6][7][8]. When these toxicities occur over a prolonged time and in a greater degree of severity, they may cause the interruption of the treatment [9].…”

Section: Introductionmentioning

confidence: 99%

“…When it is associated with undesirable adverse effects, such as chemotherapy-or radiation-related toxicities, this impact on QoL becomes even more significant [14,15]. These toxicities, especially related to the gastrointestinal tract, can be negatively associated with nutritional status, dietary intake and nutrient absorption [4,5,7].…”

Section: Introductionmentioning

confidence: 99%

Nutritional Intervention Contributes to the Improvement of Symptoms Related to Quality of Life in Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy: A Randomized Clinical Trial

Souza

Silva²,

Fayh

2021

Nutrients

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During breast cancer treatment, worsening quality of life (QoL) and the presence of toxicities are common, but healthy eating practices are associated with better clinical results. Thus, this study aims to evaluate the effect of a nutritional intervention on QoL and on gastrointestinal and hematological toxicities resulting from chemotherapy in women with breast cancer. A randomized clinical trial was performed at the beginning of neoadjuvant chemotherapy treatment for women with breast cancer. All participants received nutritional advice on healthy eating practices, but only the intervention group (IG) received an individualized diet plan. The study enrolled 34 women, 19 in the IG and 15 in the control group (CG). During the study, the CG significantly presented a reduction (from 21.6 ± 5.9 kg to 18.8 ± 4.0 kg, p = 0.009) in handgrip strength (HGS), while the IG did not present changes in this variable. Regarding QoL, the IG preserved the role function during treatment and presented better results for nausea/vomiting and loss of appetite compared to the CG. In gastrointestinal and hematological toxicities, the IG had lower frequencies of leukopenia and abdominal pain. The nutritional intervention preserved the role function of QoL and HGS, reduced the occurrence of nausea/vomiting, loss of appetite and the frequency of leukopenia and abdominal pain.

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“…5 & S13). Not only cancer disease, but also chemotherapy heavily alters cell metabolism [101][102][103][104]. Therefore, targeting of cancer (and chemotherapy) metabolism, as a complementary strategy, is a rather promising approach not only for therapeutic intervention on the disease, but also for preservation of physiological function in the patient immune system.…”

Section: Discussionmentioning

confidence: 99%

<em>Lactobacillus</em> on Recovering of Immune-Damage by Chemotherapy (Cancer Treatment)

Yue¹,

Zhang²,

Bian³

et al. 2022

Preprint

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We demonstrated the role of natural probiotics 3L, 3 Lactobacilli, in the establishment of a strong and sustainable beneficial healthy gut flora, after chemotherapy through experimental results through in vivo model. Using rat CTX model (immunosuppression induced by cyclophosphamide), we suggested some new adjuvant to chemotherapy as drugs + lactobacillus treament. Further, we proposed a new probiotic formulation (L. acidophilus + L. casei + L. plantarum) to be explored in the prevention of health condition loss by alteration of the general immune system, in numerous studies that reported the use of probiotics involving Lactobacillus in the post-chemo or post-surgical procedures. Here, in our study, Illumina MiSeq sequencing was used to generate sequencing data from microbial genomic DNA libraries, which is appreciable to check for the effects of 3L on bacteria. Microbiome analysis, phylogenetic and classification reports, community data have supported the experiments and the results where 3L had strong beneficial effects on the microbiome. Further, the influence on specific metabolic pathways are assisted in deriving the conclusion of the study (use of 3L for cancer therapy) to the mode of action, mechanistically by correcting microbiota composition and enhancing specific gut metabolic functions.

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The effects of chemotherapy on energy metabolic aspects in cancer patients: A systematic review

Cited by 40 publications

References 60 publications

Metabolomics in cancer research and emerging applications in clinical oncology

Metabolomics in cancer research and emerging applications in clinical oncology

Nutritional Intervention Contributes to the Improvement of Symptoms Related to Quality of Life in Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy: A Randomized Clinical Trial

<em>Lactobacillus</em> on Recovering of Immune-Damage by Chemotherapy (Cancer Treatment)

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