no retinal structural abnormalities suggests that even in the absence of optic nerve compression, the retinal vascular damage may precede the appearance of GCC and RNFL loss. This result assumes that the structural degeneration may be due to the interference in axoplasmic flow induced by local ischaemia at the level of the optic nerve.In conclusion, OCTA could have a valid role in the management of NF1 patients because it provides an objective, automatic and quantitative evaluation of retinal microvasculature and requires only a few seconds of collaboration. OCT angiography (OCTA) was revealed to be a useful biomarker to distinguish the early changes in retinal perfusion before the appearance of structural damages and in absence of visual acuity abnormalities in NF1 patients.