The effects of chloroform or halothane on horse liver in the early stage of ragwort poisoning

Gopinath, C.; Ford, E.J.H.; Jones, R. S.

doi:10.1002/path.1711070405

Cited by 6 publications

(2 citation statements)

References 13 publications

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“…Experimental studies have suggested a primarily biliary source for ␥GTand both biliary and hepatocellular sources for AP (Gopinath et al 1972;Leonard et al 1984;Hoffmann et al 1987). In this study, a highly significant association between the severity of biliary hyperplasia and the serum concentrations AP and ␥GT was found.…”

Section: Discussionmentioning

confidence: 99%

Retrospective analysis of historical, clinical, ultrasonographic, serum biochemical and haematological data in prognostic evaluation of equine liver disease

Durham¹,

Newton

Smith

et al. 2003

Equine Veterinary Journal

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Summary Reasons for performing study: Results of noninvasive tests of liver disease do not always correlate with the degree of hepatic disease nor outcome of the case. Objective: To investigate the prognostic value of data collected using noninvasive tests during the investigation of cases of suspected liver disease in mature horses. Hypothesis: Much of the data gathered during the investigation of suspected hepatopathy cases offers little prognostic guidance and interpretation of such data can be misleading. Methods: The results from a range of common and noninvasive diagnostic techniques applied in 116 mature horses with suspected liver disease, were assessed for their ability to predict survival within a 6 month period. Results: A significantly poorer prognosis was found in association with clinical signs suggestive of liver disease, presence of hepatic encephalopathy, ultrasonographic abnormalities, increased serum globulins, increased total bile acids (TBA), increased alkaline phosphatase (AP), increased gamma‐glutamyl transferase (γGT), erythrocytosis, leucocytosis, low serum albumin and low serum urea. Additional significant novel findings of interest included an association between increased plasma fibrinogen and low serum creatinine concentrations with nonsurvival in cases of liver disease, an association between raised serum concentrations of AP and γGT with biliary hyperplasia and also an association between hepatic fibrosis, haemosiderosis and biliary hyperplasia with ultrasonographically detected hepatic abnormalities. Conclusions: The most useful noninvasive prognostic test in cases of suspected liver disease in mature horses is the severity of clinical signs. Other data may be of some limited prognostic value. Potential relevance: Application of the findings in this study may not be directly applicable to other case populations. However, the findings should at least be considered when prognosis is based on similar criteria.

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Section: Discussionmentioning

confidence: 99%

Retrospective analysis of historical, clinical, ultrasonographic, serum biochemical and haematological data in prognostic evaluation of equine liver disease

Durham¹,

Newton

Smith

et al. 2003

Equine Veterinary Journal

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“…The degree of fibrous tissue proliferation was also less in chicks than in other species. It is suggested that the alkaloids of ragwort exert an antimitotic effect in mammals (Peterson, 1958;Gopinath et al, 1972). But in the present experiment, chicken liver responded differently by developing nodules of small proliferating cells.…”

Section: Discussionmentioning

confidence: 51%

The effect of ragwort (senecio jacobea)on the liver of the domestic fowl (gallus domesticus): A histopathological and enzyme histochemical study

Gopinath

Ford

1977

British Poultry Science

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1. Twenty-five 1-week-old male chicks were fed for 6 weeks on a standard diet incorporating 7% dried and ground ragwort (Senecio jacobea). The chicks received the standard diet for a further 6 weeks whilst a control group of 25 similar birds received the standard diet throughout. 2. Two birds from each group were killed at intervals of about 1 week and their livers were examined histologically and histochemically. 3. Ragwort feeding caused megalocytosis, focal necrosis, focal hyperplasia and portal fibrosis. There were no veno-occlusive changes. 4. As the lesion progressed there was an overall loss of enzyme activity especially in the areas of necrosis. The groups of small hyperplastic cells showed normal or increased activity and there was increased enzyme activity in the megalocytes. 5. The development of groups of proliferating cells may be a prelude to the neoplastic changes described in earlier reports of longer term studies of the effects of pyrolizidine alkaloids on the liver of chicks.

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Hepatitis in horses

Durham

Comparative Hepatitis

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The effects of chloroform or halothane on horse liver in the early stage of ragwort poisoning

Cited by 6 publications

References 13 publications

Retrospective analysis of historical, clinical, ultrasonographic, serum biochemical and haematological data in prognostic evaluation of equine liver disease

Retrospective analysis of historical, clinical, ultrasonographic, serum biochemical and haematological data in prognostic evaluation of equine liver disease

The effect of ragwort (senecio jacobea)on the liver of the domestic fowl (gallus domesticus): A histopathological and enzyme histochemical study

Hepatitis in horses

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