The Effects of ChondroT on Thrombus in FeCl₃-induced Rats

Abstract

Objectives This study was designed to investigate the effects of ChondroT on thrombus in FeCl3-induced rats. Methods We exposed FeCl3 to rat's carotid artery to induce thrombus. Specimens were divided in 5 groups; Intact, Control, ASA10 (aspirin 10 mg/kg), CT100 (ChondroT 100 mg/kg), and CT200 (ChondroT 200 mg/kg), each n=6. We investigated thromboxane, platelet activating factor (PAF), histological change, lipid metabolism, transaminase, leukocyte, erythrocyte and thrombocyte level. Results In ASA10, CT200 groups, there was significants decrease in both thromboxane level and total cholesterol level, compared to control group and there were significant histological changes of blood vessel, compared to control group. In CT200 group, there was significant decrease in PAF level, compared to control group (p<0.05). In ASA10, CT200 groups, triglycerides level tended to decrease, compared to control group. Conclusions Based on these results, it could be suggested that ChondroT was effective on thrombus in FeCl3-induced rats, and further study is needed to conduct a rigorous clinical research.

Hypertonic Dextrose Prolotherapy, an Alternative to Intra-Articular Injections With Hyaluronic Acid in the Treatment of Knee Osteoarthritis

“…HDP also decreases the expression of metalloproteinase-1 36 and induces analgesia through neurogenic mechanisms, such as the stimulation of the glycine inhibitor receptor that reduces nociceptive transmission 37 . Animal model studies have reported an increase in the cross-sectional area of the treated ligaments, 38 as well as a trophic repair effect on cartilage 39,40 . In humans, Topol et al 41 demonstrated that HDP induces a progressive trophic effect on cartilage in individuals with severe KOA, whereas Waluyo et al 28 reported that HDP could have a decreasing cartilage degradation effect measured by the reduction of urinary C-terminal telopeptide of type II collagen.…”

“…37 Animal model studies have reported an increase in the cross-sectional area of the treated ligaments, 38 as well as a trophic repair effect on cartilage. 39,40 In humans, Topol et al 41 demonstrated that HDP induces a progressive trophic effect on cartilage in individuals with severe KOA, whereas Waluyo et al 28 reported that HDP could have a decreasing cartilage degradation effect measured by the reduction of urinary C-terminal telopeptide of type II collagen. The mechanisms of action of both interventions seem to be related to anticatabolic and trophic effects on cartilage, mechanisms that are clearly different from the mechanisms of action of other interventions such as CT and ozone.…”