The effects of chronic candesartan treatment on cardiac and hepatic adenosine monophosphate-activated protein kinase in rats submitted to surgical stress

Ribeiro‐Oliveira, Antônio; Marques, Mirna Bastos; Vilas-Boas, Walkíria Wingester; Guimarães, Jonas; Coimbra, Cândido Celso; Anjos, Allan P; Fóscolo, Rodrigo Bastos; Santos, Robson A.S.; Thomas, Julia; Igreja, Susana; Kola, Blerina; Grossman, Ashley; Korbonits, Márta

doi:10.1177/1470320313499199

Cited by 4 publications

(2 citation statements)

References 39 publications

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“…Furthermore, telmisartan treatment prevented weight gain [79]. AMPK activation has also been reported after administration of other angiotensin receptor blockers ('sartans') such as losartan, olmesartan, or candesartan [80][81][82]. Some of these drugs were also associated with improved exercise capacity [83][84][85], but this effect was not directly linked to AMPK activation.…”

Section: Telmisartanmentioning

confidence: 91%

Activation of AMPK and its Impact on Exercise Capacity

et al. 2015

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Activation of the adenosine monophosphate (AMP)-activated kinase (AMPK) contributes to beneficial effects such as improvement of the hyperglycemic state in diabetes as well as reduction of obesity and inflammatory processes. Furthermore, stimulation of AMPK activity has been associated with increased exercise capacity. A study published in 2008, directly before the Olympic Games in Beijing, showed that the AMPK activator AICAR (5-amino-1-β-D-ribofuranosyl-imidazole-4-carboxamide) increased the running capacity of mice without any training and thus, prompted the World Anti-Doping Agency (WADA) to include certain AMPK activators in the list of forbidden drugs. This raises the question as to whether all AMPK activators should be considered for registration or whether the increase in exercise performance is only associated with specific AMPK-activating substances. In this review, we intend to shed light on currently published AMPK-activating drugs, their working mechanisms, and their impact on body fitness.

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Section: Telmisartanmentioning

confidence: 91%

Activation of AMPK and its Impact on Exercise Capacity

et al. 2015

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“…ROCHA et al (2015) demonstraram que a ativação da AMPK no fígado induzida pelo consumo de chá-verde modula a expressão de genes envolvidos no metabolismo, e por isso poderia ser uma estratégia terapêutica para combater a resistência à insulina, dislipidemia e obesidade em ratos. OFIR et al (2007), MARCINKO et al (2014), MOTTILLO et al (2017) e TAN et al (2017 mostraram que durante o exercício físico, a ativação da AMPK fosforila proteínas alvos, tais como ACC fosforilada (inativa), que por sua vez, diminui a ação inibitória da malonil-coa sobre a CPT-1, uma importante proteína transportadora de ácidos graxos na mitocôndria (RIBEIRO-OLIVEIRA et al, 2013).…”

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Papel da alça ECA2/Ang 1-7/Mas na prevenção da doença hepática gordurosa não alcoólica por meio do treinamento físico aeróbio

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Autorizo a reprodução e divulgação total ou parcial deste trabalho, por qualquer meio convencional ou eletrônico, para fins de estudo e pesquisa, desde que citada a fonte. The SED-CAF group presented higher body weight gain, lipid and IL-6 content in the liver, and APT prevented these increases in the TF-CAF group. No differences were observed in the concentration of ALT and AST enzymes, in the expression of genes related to lipid metabolism and in the expression of AMPK, PGC1-α, SIRT-1, ACC and receptor Mas in the liver. TF-NO and TF-CAF groups had higher serum ACE2 activity compared to SED-NO and SED-CAF, however ACE2 activity and Ang1-7 content were not different among groups. TF-NO showed lower ACE activity in the liver compared to the TF-CAF group. CATALOGAÇÃOCollectively, the results showed that APT prevented NAFLD evidenced by the lower lipid content and pro-inflammatory cytokine IL-6, however, this response is independent of changes in gene expression and in hepatic metabolism regulatory proteins expression associated with the SRA ACE2/Ang1-7/Mas axis.

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Telmisartan and candesartan promote browning of white adipose tissue and reverse fatty liver changes in high fat diet fed male albino rats

Abbas,

Fayed,

El Sebaey

et al. 2023

Naunyn-Schmiedeberg's Arch Pharmacol

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The effects of chronic candesartan treatment on cardiac and hepatic adenosine monophosphate-activated protein kinase in rats submitted to surgical stress

Abstract: While chronic candesartan treatment may stimulate AMPK activity in certain organs such as the liver, when combined with surgical stress under anesthesia it inhibits pathways regulating AMPK activity.

Cited by 4 publications

References 39 publications

Activation of AMPK and its Impact on Exercise Capacity

Activation of AMPK and its Impact on Exercise Capacity

Papel da alça ECA2/Ang 1-7/Mas na prevenção da doença hepática gordurosa não alcoólica por meio do treinamento físico aeróbio

Telmisartan and candesartan promote browning of white adipose tissue and reverse fatty liver changes in high fat diet fed male albino rats

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