The Effects of Chronic Marijuana Administration on 6-OHDA-Induced Learning &amp; Memory Impairment and Hippocampal Dopamine and Cannabinoid Receptors Interaction in Male Rats

Haghparast, Elham; Sheibani, Vahid; Komeili, Gholamreza; Chahkandi, Mohadeseh; Rad, Nahid Sepehri

doi:10.1007/s11064-023-03899-8

Cited by 6 publications

(1 citation statement)

References 55 publications

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“…The effect of marijuana on cognitive impairment caused by 6-OHDA and on the expression of dopamine and cannabinoid receptors in the rat hippocampus was studied in tests with Morris water maze (VLM) and recognition of new objects [33]. The expression levels of cannabinoid receptors and dopamine receptors D1R and D2R in the hippocampus were assessed using real-time PCR.…”

Section: The Use Of Ecs Modulators In Experimental Models Of Parkinso...mentioning

confidence: 99%

Outcomes and Outlooks of Therapeutic Application of Modulators of Endogenous Cannabinoid System in Parkinson's Disease

Khaspekov,

Illarioshkin

2024

Preprint

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Recent studies have shown that the endogenous cannabinoid system (ECS) of the brain is essentially involved in the pathogenesis of Parkinson's disease (PD), influencing its symptoms by regulating the level of endogenous cannabinoids and altering the activation of cannabinoid receptors (CBR). Therefore, modulation of ECS with new drugs developed for this purpose may prove to be a promising strategy in the treatment of PD. However, fine regulation of ECS is quite a challenge due to the functional diversity of CBR in the basal ganglia. Our review analyses the effects of ECS modulators on experimental PD models and in patients with PD, as well as presents the outlooks for the development of new cannabinoid drugs for the treatment of motor and non-motor symptoms in PD.

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Section: The Use Of Ecs Modulators In Experimental Models Of Parkinso...mentioning

confidence: 99%

Outcomes and Outlooks of Therapeutic Application of Modulators of Endogenous Cannabinoid System in Parkinson's Disease

Khaspekov,

Illarioshkin

2024

Preprint

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The interaction between cannabinoids and long‐term synaptic plasticity: A survey on memory formation and underlying mechanisms

Azarfarin,

Ghadiri,

Dadkhah

et al. 2024

Cell Biochemistry & Function

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Synaptic plasticity, including long‐term potentiation (LTP) and long‐term depression (LTD), is an essential phenomenon in memory formation as well as maintenance along with many other cognitive functions, such as those needed for coping with external stimuli. Synaptic plasticity consists of gradual changes in the biochemistry and morphology of pre‐ and postsynaptic neurons, particularly in the hippocampus. Consuming marijuana as a primary source of exocannabinoids immediately impairs attention and working memory‐related tasks. Evidence regarding the effects of cannabinoids on LTP and memory is contradictory. While cannabinoids can affect a variety of specific cannabinoid receptors (CBRs) and nonspecific receptors throughout the body and brain, they exert miscellaneous systemic and local cerebral effects. Given the increasing use of cannabis, mainly among the young population, plus its potential adverse long‐term effects on learning and memory processes, it could be a future global health challenge. Indeed, the impact of cannabinoids on memory is multifactorial and depends on the dosage, timing, formula, and route of consumption, plus the background complex interaction of the endocannabinoids system with other cerebral networks. Herein, we review how exogenously administrated organic cannabinoids, CBRs agonists or antagonists, and endocannabinoids can affect LTP and synaptic plasticity through various receptors in interaction with other cerebral pathways and primary neurotransmitters.

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Exploring the Diversity of Cannabis Cannabinoid and Non-Cannabinoid Compounds and Their Roles in Alzheimer's Disease: A Review

Doumar,

Mostafi,

Elhessni

et al. 2024

IBRO Neuroscience Reports

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The Effects of Chronic Marijuana Administration on 6-OHDA-Induced Learning & Memory Impairment and Hippocampal Dopamine and Cannabinoid Receptors Interaction in Male Rats

Cited by 6 publications

References 55 publications

Outcomes and Outlooks of Therapeutic Application of Modulators of Endogenous Cannabinoid System in Parkinson's Disease

Outcomes and Outlooks of Therapeutic Application of Modulators of Endogenous Cannabinoid System in Parkinson's Disease

The interaction between cannabinoids and long‐term synaptic plasticity: A survey on memory formation and underlying mechanisms

Exploring the Diversity of Cannabis Cannabinoid and Non-Cannabinoid Compounds and Their Roles in Alzheimer's Disease: A Review

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