Tables: 3 2 Abstract Purpose: The aim of this study was to determine whether gastrointestinal (GI) distress affects the ergogenicity of sodium bicarbonate and whether the degree of alkalaemia or other metabolic responses are different between individuals who improve exercise capacity and those who do not. Methods: Twenty-one males completed two cycling capacity tests at 110% of maximum power output. Participants were supplemented with 0.3 g•kg -1 BM of either placebo (maltodextrin) or sodium bicarbonate (SB). Blood pH, bicarbonate, base excess and lactate were determined at baseline, pre-exercise, immediately post-exercise and 5 minutes post-exercise. Results: SB supplementation did not significantly increase total work done (TWD) (P = 0.16, 46.8 ± 9.1 vs. 45.6 ± 8.4 kJ, d = 0.14), although magnitude based inferences suggested a 63% likelihood of a positive effect. When data were analysed without four participants who experienced GI discomfort, TWD (P = 0.01) was significantly improved with SB. Immediately post-exercise blood lactate was higher in SB for the individuals who improved but not for those who didn't. There were also differences in the pre to post-exercise change in blood pH, bicarbonate and base excess between individuals who improved and individuals who did not. Conclusions: SB improved high intensity cycling capacity, but only with the exclusion of participants experiencing GI discomfort. Differences in blood responses suggest that sodium bicarbonate may not be beneficial to all individuals. Magnitude based inferences suggested that the exercise effects are unlikely to be negative; therefore individuals should determine whether they respond well to sodium bicarbonate supplementation prior to competition. Key words: Extracellular buffering, high-intensity exercise, gastrointestinal distress, blood responses, inter-individual variability 3
IntroductionThe effects of sodium bicarbonate supplementation on exercise performance and capacity have been well researched (for review see 1 ), and a recent meta-analysis showed that 0.3 g·kg -1 Body Mass (BM) sodium bicarbonate supplementation prior to a 60 s sprint improved performance by 1.7 ± 2.0% 2 . Despite this, the reported effects are equivocal, with several studies reporting no effect on exercise performance and capacity 3,4,5,6,7 . Inconsistencies in the performance outcomes of sodium bicarbonate supplementation studies can be partly attributed to differing dosing regimens 4 , gastrointestinal (GI) discomfort experienced by some participants 8 , exercise models insufficient to be limited by hydrogen cation (H + ) accumulation 5 and individual variation in the response to supplementation 9 .