The effects of chronic uremia and dexamethasone on triglyceride kinetics in the rat

Gregg, Richard C.; Diamond, A. Godwin; Mondon, Carl E.; Reaven, Gerald M.

doi:10.1016/0026-0495(77)90006-3

Cited by 27 publications

(7 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Decay curve of serum 4-14 C-cholesterol was used for the calculation of the half-time (t 1/2 ) and the fractional catabolic rate (FCR) derived from the relation: ln dpm 1 of serum versus time by a least-square regression analysis [18]. The results were statistically evaluated by Student's t-test.…”

Section: Methodsmentioning

confidence: 99%

The effect of dried tomato, grape and apple pomace on the cholesterol metabolism and antioxidative enzymatic system in rats with hypercholesterolemia

Bobek

Ozdín

Hromadová

1998

Nahrung

View full text Add to dashboard Cite

The effect of dried tomato, grape and apple pomace (5% in diet) on the cholesterol levels in serum and selected organs was studied in male Wistar rats fed a cholesterol diet (0.3%) shortly after weaning. Pomace of individual fruits contained 47.2, 67.0 and 46.2 g of total dietary fiber per 100 g of dry matter for tomato, grape and apple pomace, respectively. Corresponding values for the soluble components of the fiber were 10.3, 14.7 and 26.0%. None of the tested products affected the serum cholesterol levels. Tomato and apple pomace significantly reduced cholesterol level in liver by 15% and 11%, respectively, and all tested pomace species reduced cholesterol content in heart (by 18-21%). Triacylglycerol content was affected only by tomato pomace and solely in the heart. Cholesterol absorption measured by dual-isotope ratio method, was not significantly affected by the pomace, however, all products strongly reduced (up to the half of the original value) the activity of HMG-CoA reductase in liver and increased the fractional catabolic rate of plasma cholesterol (by 60-120%). All tested pomace reduced plasma levels of conjugated dienes and tomato and grape pomace exhibited this effect also in the liver. All tested pomace reduced the activities of antioxidant enzymes superoxid dismutase, catalase and glutathione peroxidase in erythrocytes (by 34-56%).

show abstract

Section: Methodsmentioning

confidence: 99%

The effect of dried tomato, grape and apple pomace on the cholesterol metabolism and antioxidative enzymatic system in rats with hypercholesterolemia

Bobek

Ozdín

Hromadová

1998

Nahrung

View full text Add to dashboard Cite

show abstract

“…We do not believe that the current results satisfy this condi tion. Studies in rats with CRF have demonstrated that hypertriglyceridemia occurs in the absence of any change in VLDL-TG secretion [6], Thus, a profound defect in removal of VLDL-TG from plasma must exist in this situation in order for hypertriglyceridemia to develop. If reduced tissue LPL activity is the prime cause of the removal defect, the reduction should be quantitatively profound.…”

Section: Discussionmentioning

confidence: 99%

Hypertriglyceridemia and Lipoprotein Lipase Activity in Experimental Uremia

Kraemer¹,

Chen²,

Reaven³

1982

Nephron

Self Cite

View full text Add to dashboard Cite

The relationship between changes in tissue lipoprotein lipase (LPL) activity and triglyceride (TG) concentration has been studied in chronically uremic rats. Uremic rats had a 6-fold increase in BUN and 75% rise in TG levels associated with a 50% reduction in adipose tissue heparin-releasable LPL activity. However, total LPL activity of adipose tissue and muscle was not significantly decreased. Furthermore, there was no significant correlation between the rise in plasma TG concentration seen in uremic rats and the reduction in heparin-releasable adipose tissue LPL activity. These data suggest that the TG removal defect associated with chronic uremia is not a simple function of a decrease in LPL activity.

show abstract

“…Indeed, Gregg et al (1977) M.H. Tan postulated that it is due to further suppression of adipose tissue LPL by the glucocorticoids (Bagdade et al 1976).…”

Section: Discussionmentioning

confidence: 99%

“…Rats with chronic uremia have hypertriglyceridemia secondary to defective removal of triglyceride-rich (Tg-rich) lipoproteins {Gregg, Diamond, Mondon and Reaven 1977). Their triglyceride secretion rate (TgSR) is normal and the T 1/2 of removal of labelled very low density lipoproteins (VLDL) in these rats is significantly prolonged when compared with sham operated rats, implying a defect in removal of Tg-rich lipoproteins.…”

Section: Introductionmentioning

confidence: 98%

Is the Glucocorticoid-Induced Hypertriglyceridemia in Uremic Rats Caused by Decreased Tissue Lipoprotein Lipase Activity?

Ming¹

1985

Horm Metab Res

View full text Add to dashboard Cite

The glucocorticoid-induced hypertriglyceridemia in uremic rats is partly due to defective removal of triglyceride (Tg)-rich lipoproteins. To determine whether this was due to decreased lipoprotein lipase (LPL), the key enzyme involved in the hydrolysis of Tg-rich lipoproteins, the LPL activity in soleus, heart and adipose tissue and the triglyceride secretion rates (TgSR) of uremic rats treated with Triamcinolone or placebo were studied. Sprague-Dawley rats were made uremic by a 2-stage 5/6 nephrectomy and studied three weeks later. During the 3rd week, one group was treated with a five day course of Triamcinolone (0.5 mg/kg body weight i.m.) and the other given an equal volume of saline. Triamcinolone aggravated the hypertriglyceridemia in uremic rats. This was associated with an increase in soleus and heart LPL with no change in adipose tissue LPL. The TgSR was also increased in the Triamcinolone-treated rats. These data suggest that decreased LPL activity is not the cause of hypertriglyceridemia in these rats.

show abstract

The effects of chronic uremia and dexamethasone on triglyceride kinetics in the rat

Cited by 27 publications

References 20 publications

The effect of dried tomato, grape and apple pomace on the cholesterol metabolism and antioxidative enzymatic system in rats with hypercholesterolemia

The effect of dried tomato, grape and apple pomace on the cholesterol metabolism and antioxidative enzymatic system in rats with hypercholesterolemia

Hypertriglyceridemia and Lipoprotein Lipase Activity in Experimental Uremia

Is the Glucocorticoid-Induced Hypertriglyceridemia in Uremic Rats Caused by Decreased Tissue Lipoprotein Lipase Activity?

Contact Info

Product

Resources

About