The effects of chrysin and pinostrobin, two flavonoids isolated from Teloxys graveolens leaves, on isolated guinea-pig ileum

Chrysin inhibits metastatic potential of human triple‐negative breast cancer cells by modulating matrix metalloproteinase‐10, epithelial to mesenchymal transition, and PI3K/Akt signaling pathway

“…Chrysin, a naturally occurring flavone in the passion flower (Passiflora caerulea) and honeycomb, has been shown to exert a variety of pharmacological effects such as antioxidant, antidiarrheal and anti-inflammatory activities (Gresa-Arribas et al, 2010;Meckes et al, 1998;Pushpavalli et al, 2010). Recently, a number of studies have demonstrated that chrysin possessed antiproliferative and proapoptotic activities in leukemia, and cervical, esophageal, prostate, thyroid and breast cancers, suggesting *Correspondence to: Hongzhong Li and Guosheng Ren,Molecular Oncology and Epigenetics Laboratory,The First Affiliated Hospital of Chongqing Medical University,No.1 Youyi Road,Yuzhong District,Chongqing,400016, that chrysin is a potential antitumor agent.…”

Protective Effects of Pinostrobin on β-Amyloid-Induced Neurotoxicity in PC12 Cells

“…It is worth noting that Folium Cajani contains about 0.25% of pinostrobin (Yuan et al 2010). Recent pharmacological researches have revealed diverse biological activities of pinostrobin, including suppression of spontaneous contractions of intestinal smooth muscle (Meckes et al 1998), inhibition of aromatase activity, antiproliferation on estrogen-induced cells (Le Bail et al 2000), antiinflammatory effects by inhibition of cycloxygenases (Wu et al 2002), and attenuation of sodium channel-activated depolarization of mouse brain synaptoneurosomes (Nicholson et al 2010). In addition, pinostrobin has strong antioxidant effect in vitro (Fahey and Stephenson 2002).…”

HPLC Determination of the Major Active Flavonoids and GC–MS Analysis of Volatile Components of Dysphania graveolens (Amaranthaceae)

“…Pinocembrin ( 2 ) exhibited fasciolicide and ovicide activity against newly excysted Fasciola hepatica and infective eggs of Ascaridia galli (Camacho et al ., ). Pinostrobin ( 1 ) and chrysin ( 3 ) inhibited intestinal smooth muscle contractions of guinea‐pig ilea preparations by a calcium‐mediated mechanism (Meckes et al ., ). Altogether, these studies have provided scientific support for some of the popular uses of the plant and demonstrated that flavonoids 1–3 are the most important active principles against gastrointestinal ailments.…”

“…A few components have been isolated from D. graveolens including sterols (stigmasterol, stigmast-22-en-3-ol and 3asitosteryl glucoside), flavonoids (pinostrobin (1), pinocembrin (2), chrysin (3), rutin and narcissin), sesquiterpenoids ((+)-8ahydroxyelemol, (+)-8a-acetoxycryptomeridiol and cryptomeridiol) and melilotoside, an o-coumaric acid derivative (Mata et al, 1987;Calzada et al, 2003). The pharmacological studies conducted on extracts and compounds from the plant have shown their anthelmintic (Camacho et al, 1991), antiseptic (Rojas et al, 1992), antiprotozoal (Calzada et al, 2003) and spasmolytic activities (Meckes et al, 1998). Thus, the methanolic extract of the plant and melilotoside exhibited potent activity toward Entamoeba histolytica and Giardia lamblia, while narcissin was selectively active against E. histolytica (Calzada et al, 2003).…”