The effects of Ciji-Hua’ai-Baosheng on immune function of mice with H22 hepatocellular carcinoma receiving chemotherapy

Xi, Shengyan; Fu, Biqian; Loy, G; Minuk, Gerald Y.; Peng, Ying; Qiu, Yinkun; Zhai, Xiangyang; Wang, Yujie; Li, Pengfei; Gong, Yuewen; Wang, Jing; Huang, Shuqiong; Lü, Dawei; Wang, Yanhui

doi:10.1016/j.biopha.2018.03.027

Cited by 12 publications

(11 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The group investigated the effect of CHBG on general health and survival time in H22 mice model with chemotherapy treatment, showing that CHBG obviously contributed to survival time of mice bearing subcutaneous transplanted tumor or ascitic tumor (Xi et al, 2014). One step further, CHBG was identified as complementary therapy for patients undertaking chemotherapy by improving immune function and attenuating side effects (Xi et al, 2018). It is well known that exercise is favorable in overcoming and preventing ailments and diseases; the combined application of exercise and herbal formulas has not yet been largely studied.…”

Section: Complementary Therapy For Liver Cancer Managementmentioning

confidence: 99%

Uncovering the Anticancer Mechanisms of Chinese Herbal Medicine Formulas: Therapeutic Alternatives for Liver Cancer

et al. 2020

View full text Add to dashboard Cite

The potential values of Chinese herbal formulas in treating various diseases are well known. In addition to more than 2,000 years of history, herbal medicine is appreciated for its remarkable efficacy in a lot of cases, which warrants a role in public health care worldwide, especially in East Asian countries. Liver cancer is the second most fatal cancer across the world. Recent studies have extensively investigated the chemical profiles and pharmacological effects of Chinese herbal medicine formulas on liver cancer. Either through observational follow-up or experimental studies, multiple herbal formulas have benefits implicated in the management of liver cancer. However, complex composition of each formula imposes restrictions on promoting clinical practice and global recognition. Therefore, understanding the mode of action of Chinese herbal medicine formulas in depth may offer sufficient evidence for their clinical use. This review highlighted the chemical characteristics and molecular mechanisms of actions of prominent Chinese herbal medicine formulas and summarized the correlated findings on the potential use in liver cancer treatment. At last, the present progresses of Chinese herbal medicine formulas in the perspective of clinical trials are discussed.

show abstract

Section: Complementary Therapy For Liver Cancer Managementmentioning

confidence: 99%

Uncovering the Anticancer Mechanisms of Chinese Herbal Medicine Formulas: Therapeutic Alternatives for Liver Cancer

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Clinical observations supported the beneficial effect of CHBF on cancer patients receiving chemotherapy, which reported in a Chinese patent that CHBF was used for the treatment of dozens of lung cancer and primary liver cancer patients, and after years of observation, the results indicated that it could relieve discomfort symptoms and prolong survival time [13]. Laboratory studies have also revealed that CHBF can prolong the lifespan of mice with ascitic H 22 hepatocellular carcinoma, inhibit tumor growth, prevent decrease of white blood cells and platelets, and improve the immune function of H 22 tumor bearing mice receiving chemotherapy [14, 15].…”

Section: Introductionmentioning

confidence: 99%

“…Ciji-Hua'ai-Baosheng II Formula (CHB-II-F), as a new Chinese medical formula for reducing the recurrence rate of cancer patients [13], is a second generation formula refined from the original Ciji Hua'ai Baosheng Decoction (CHBD) [15] without changing the principles of treatment in order to better facilitate its subsequent applications and further development. CHB-II-F retains the most important eight medicinals in CHBD and is composed of Radix Codonopsis, Semen Ziziphi Spinosae, Fructus Hordei Germinatus, Pericarpium Citri Reticulatae, Poria, Concha Ostreae, Bulbus Fritillariae Ussuriensis, and Radix Salviae Miltiorrhizae.…”

Section: Introductionmentioning

confidence: 99%

Safety Evaluation of a New Traditional Chinese Medical Formula, Ciji-Hua’ai-Baosheng II Formula, in Adult Rodent Models

Zhai

et al. 2019

Evidence-Based Complementary and Alternative Medicine

Self Cite

View full text Add to dashboard Cite

Background Ciji-Hua'ai-Baosheng II Formula (CHB-II-F) is a new traditional Chinese medical formula that has been shown to reduce toxicity and side effects of chemotherapy and increase the probability of cancer patient survival. Whether CHB-II-F is safe as an adjunctive therapy for cancer patients receiving chemotherapy has yet to be determined. Purpose To evaluate the acute and subchronic toxic effects of CHB-II-F in rodent models. Methods In acute toxicity test, 24 Kunming mice were divided into 2 groups: untreated control and CHB-II-F 1.05 g/mL (31.44 g/kg) treated group. Treatment was administered to the treated group 3 times a day for 14 days. The overall health, adverse reactions, and mortality rate were documented. In subchronic toxicity test, 96 Sprague-Dawley rats were divided into 4 groups: untreated control, high dose CHB-II-F (H) (26.20 g/kg), medium dose CHB-II-F (M) (13. 10 g/kg), and low dose CHB-II-F (L) (6.55 g/kg) [equal to 24.375 g (dried medicinal herb)/kg] treated groups. Treated groups were given the treatments once a day for 4 weeks. The overall health and mortality rate were recorded every day. Body weight and food consumption were measured once a week. Hematologic and biochemical parameters, organ weights, and histopathologic markers were analyzed after 4 weeks. An additional 2 weeks were given as the treatment recovery period before end-point euthanization, and biochemical analyses were performed. Results The maximum tolerated dose (MTD) of CHB-II-F on mice was found to be 94.31 g/kg [equal to 351 g (dried medicinal herb)/kg], which is 108 times the human adult dose. In the acute toxicity test, administration of CHB-II-F 31.44 g/kg showed no adverse effect and did not cause mortality. In the subchronic toxicity test, after 4 weeks of treatment, compared to the controls, total cholesterol (TCHO) level, cardiac and splenic indexes, body weights of female rats, and mean corpuscular hemoglobin concentration (MCHC) in the CHB-II-F (H) group were significantly increased; triglyceride (TG) in the CHB-II-F (M) group and liver and splenic indexes in the CHB-II-F (L) group were increased. After the two-week recovery period, biofluid analyses, food consumption, and histopathologic examinations showed no abnormalities. Conclusion Administration of CHB-II-F had no obvious adverse effect on the overall health of rodent models. A daily maximum dose of less than 94.31 g/kg or 6.55 g/kg CHB-II-F for 4 continuous weeks was considered safe.

show abstract

“…For instance, Shenling Baizhu powder is used to treat patients with leukemia receiving chemotherapy (Liu et al, 2012); Gujin Moji tablet has been shown to protect and promote bone marrow hematopoiesis in tumor-bearing mice with chemotherapy (Chen et al, 1998). Early studies revealed that first generation Ciji-Hua’ai-Baosheng Formula can prolong life of mice with transplanted ascitic H 22 hepatocellular carcinoma, inhibit tumor growth, antagonize the decrease of white blood cells and platelets following chemotherapy, promote the production and activity of erythropoietin (EPO) and granulocyte-macrophage colony stimulating factor (GM-CSF), maintain the stability of peripheral blood cells, and improve immune functions (Xi et al, 2014; Cheng et al, 2016; Xi et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

“…Although tumor is targeted and removed, the internal environment of the body has not been changed fundamentally, and thus can induce tumor recurrence and metastasis (Lai et al, 2014). CHB-II-F is formulated based on Professor Wang’s extensive clinical experience (Wang and Xi, 2017), and is a second generation of formula refined from the original Ciji Hua’ai Baosheng Decoction (CHBD) (Cheng et al, 2016; Xi et al, 2018) without changing the principles of treatment in order to better facilitate its subsequent applications and further development. CHB-II-F is consisted of Radix Codonopsis, Semen Ziziphi Spinosae, Fructus Hordei Germinatus, Pericarpium Citri Reticulatae, Poria, Concha Ostreae, Bulbus Fritillariae Ussuriensis and Radix Salviae Miltiorrhizae.…”

Section: Introductionmentioning

confidence: 99%

The Protective Effects of Ciji-Hua’ai-Baosheng II Formula on Chemotherapy-Treated H22 Hepatocellular Carcinoma Mouse Model by Promoting Tumor Apoptosis

Wang

et al. 2019

Front. Pharmacol.

Self Cite

View full text Add to dashboard Cite

Ciji-Hua’ai-Baosheng II Formula (CHB-II-F) is a traditional Chinese medical formula that has been shown in clinical practice to relieve side effects of chemotherapy and improve quality of life for cancer patients. In order to understand the mechanism of its protective effects on chemotherapy, mice with transplanted H22 hepatocellular carcinoma were employed in this study. Ninety-two mice were injected subcutaneously with H22 HCC cell suspension into the right anterior armpit. After mice were treated with 5-fluorine pyrimidine (5-FU), they were divided into six groups as untreated group, 5-FU group, 5-FU plus Yangzheng Xiaoji Capsule group and three groups of 5-FU plus different concentrations of CHB-II-F. Twenty mice were euthanized after 7 days of treatment in untreated and medium concentration of CHB-II-F groups and all other mice were euthanized after 14 days of treatment. Herbal components/metabolites were analyzed by UPLC-MS. Tumors were evaluated by weight and volume, morphology of light and electron microscope, and cell cycle. Apoptosis were examined by apoptotic proteins expression by western blot. Four major components/metabolites were identified from serum of mice treated with CHB-II-F and they are β-Sitosterol, Salvianolic acid, isobavachalcone, and bakuchiol. Treatment of CHB-II-F significantly increased body weights of mice and decreased tumor volume compared to untreated group. Moreover, CHB-II-F treatment increased tumor cells in G0-G1 transition instead of in S phase. Furthermore, CHB-II-F treatment increased the expression of pro-apoptotic proteins and decreased the expression anti-apoptotic protein. Therefore, CHB-II-F could improve mice general condition and reduce tumor cell malignancy. Moreover, CHB-II-F regulates apoptosis of tumor cells, which could contribute its protective effect on chemotherapy.

show abstract

The effects of Ciji-Hua’ai-Baosheng on immune function of mice with H22 hepatocellular carcinoma receiving chemotherapy

Cited by 12 publications

References 37 publications

Uncovering the Anticancer Mechanisms of Chinese Herbal Medicine Formulas: Therapeutic Alternatives for Liver Cancer

Uncovering the Anticancer Mechanisms of Chinese Herbal Medicine Formulas: Therapeutic Alternatives for Liver Cancer

Safety Evaluation of a New Traditional Chinese Medical Formula, Ciji-Hua’ai-Baosheng II Formula, in Adult Rodent Models

The Protective Effects of Ciji-Hua’ai-Baosheng II Formula on Chemotherapy-Treated H22 Hepatocellular Carcinoma Mouse Model by Promoting Tumor Apoptosis

Contact Info

Product

Resources

About