The effects of cis-platinum(II)diamminodichloride, UV light and N-methyl-N′-nitro-N-nitrosoguanidine on Escherichia coli: Plasmid mediated resistance to mutagens

Jarosik, Gregory P.; Beck, Doris J.

doi:10.1016/0009-2797(84)90033-4

Cited by 20 publications

(25 citation statements)

References 28 publications

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“…The best evidence for this involvement is the necessity of the umuC,D gene products for the expression of cisplatin induced mutagenesis 129,[131][132][133]. However, mutagenesis by cis-DDP in Escherichia coli is strongly reduced or abolished in either uvr A or uvrB mutants 25,127,130,133) while mutagenesis by classical SOS inducers such as ultraviolet irradiation are increased in uvr deficient strains 30).…”

Section: Mutagenic Platinum-dna Adductsmentioning

confidence: 96%

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Metal Antitumor Compounds: The Mechanism of Action of Platinum Complexes

Johnson

Butour

Villani

et al. 1989

Progress in Clinical Biochemistry and Medicine

164

122

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Cisplatin (cis-diamminedichloroplatinum(II») is widely used in the treatment of testicular and ovarian cancers. A number of biological and biochemical results indicate that the reaction of cisplatin with DNA is responsible for the cytotoxic action of this drug. The effect of platinum compounds on the conformation and stability of DNA has been investigated and several platinum-DNA adducts have been identified in vitro and in vivo. Preliminary experiments have quantified the effect of these different lesions on DNA replication, their capacity to induce mutations and their susceptibility to DNA repair processes. Additional DNA damage may be created by platinum(IV) compounds, perhaps during their reduction to platinum(II) compounds by the cell.

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Section: Mutagenic Platinum-dna Adductsmentioning

confidence: 96%

“…SOS mediated error-prone rapeir is implicated in the mutagenesis of both Salmonella typhimurium and Escherichia coli by cis-DDP 25,[129][130][131]. The best evidence for this involvement is the necessity of the umuC,D gene products for the expression of cisplatin induced mutagenesis 129,[131][132][133].…”

Section: Mutagenic Platinum-dna Adductsmentioning

confidence: 99%

Metal Antitumor Compounds: The Mechanism of Action of Platinum Complexes

Johnson

Butour

Villani

et al. 1989

Progress in Clinical Biochemistry and Medicine

164

122

View full text Add to dashboard Cite

show abstract

“…We can obtain the value of the parameter m using the measured amplitude of temperature perturbations in the CMB [28,29] δ = 2 × 10 −5 , and as in [30,31], we get m = 7 × 10 −6 M pl (n − 1) 1/4 . The values for the slow roll parameters at the beginning of inflation can also be obtained by using (54) to give ǫ i = 8.3 × 10 −3 and η i = 8.3 × 10 −3 .…”

Section: A Inflation Driven By a Potential Fieldmentioning

confidence: 98%

Generalizing a unified model of dark matter, dark energy, and inflation with a noncanonical kinetic term

De-Santiago

Cervantes-Cota

2011

Phys. Rev. D

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We study a unification model for dark energy, dark matter, and inflation with a single scalar field with non canonical kinetic term. In this model the kinetic term of the Lagrangian accounts for the dark matter and dark energy, and at early epochs a quadratic potential accounts for slow roll inflation. The present work is an extension to the work by Bose and Majumdar [Phys. Rev. D 79, 103517 (2009).] with a more general kinetic term that was proposed by Chimento in Phys. Rev. D 69, 123517 (2004). We demonstrate that the model is viable at the background and linear perturbation levels.

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“…Finally, we ran an additional set D simulation of another Milky Way-sized halo in a 67 Mpc comoving box with a mass resolution 8.2 × 10 4 M ⊙ and gravitational softening length 196 pc. Table 1 lists sets of cosmological parameters from measurements of the cosmic microwave background by WMAP and the Planck mission (Spergel et al 2003(Spergel et al , 2007Komatsu et al 2009;Larson et al 2010;Jarosik et al 2010;Komatsu et al 2011;Hinshaw et al 2012;Planck Collaboration et al 2013). "Bolshoi" are the parameters from the Bolshoi simulation (Klypin, Trujillo-Gomez & Primack 2011) which were chosen to be within 1σ of WMAP5, WMAP7, and consistent with the results of supernovae, and X-ray cluster surveys.…”

Section: Simulationsmentioning

confidence: 99%

Massive Milky Way satellites in cold and warm dark matter: dependence on cosmology

Polisensky¹,

Ricotti²

2013

Monthly Notices of the Royal Astronomical Society

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We investigate the claim that the largest subhaloes in high resolution dissipationless cold dark matter (CDM) simulations of the Milky Way are dynamically inconsistent with observations of its most luminous satellites. We find that the inconsistency is largely attributable to the large values of σ 8 and n s adopted in the discrepant simulations, producing satellites that form too early and therefore are too dense. We find the tension between observations and simulations adopting parameters consistent with WMAP9 is greatly diminished, making the satellites a sensitive test of CDM. We find the Via Lactea II halo to be atypical for haloes in a WMAP3 cosmology, a discrepancy that we attribute to its earlier formation epoch than the mean for its mass. We also explore warm dark matter (WDM) cosmologies for 1-4 keV thermal relics. In 1 keV cosmologies subhaloes have circular velocities at kpc scales ∼ 60% lower than their CDM counterparts, but are reduced by only 10% in 4 keV cosmologies. Since relic masses < 2-3 keV are ruled out by constraints from the number of Milky Way satellites and Lyman-α forest, WDM has a minor effect in reducing the densities of massive satellites. Given the uncertainties on the mass and formation epoch of the Milky Way, the need for reducing the satellite densities with baryonic effects or WDM is alleviated.

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The effects of cis-platinum(II)diamminodichloride, UV light and N-methyl-N′-nitro-N-nitrosoguanidine on Escherichia coli: Plasmid mediated resistance to mutagens

Cited by 20 publications

References 28 publications

Metal Antitumor Compounds: The Mechanism of Action of Platinum Complexes

Metal Antitumor Compounds: The Mechanism of Action of Platinum Complexes

Generalizing a unified model of dark matter, dark energy, and inflation with a noncanonical kinetic term

Massive Milky Way satellites in cold and warm dark matter: dependence on cosmology

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