In irrigated areas, the intelligent management and scientific decision-making of agricultural irrigation are premised on the accurate estimation of the ecological water demand for different crops under different spatiotemporal conditions. However, the existing estimation methods are blind, slow, or inaccurate, compared with the index values of the water demand collected in real time from irrigated areas. To solve the problem, this paper innovatively introduces the spatiotemporal features of ecological water demand to the forecast of future water demand by integrating an artificial neural network (ANN) for water demand prediction with the prediction indices of water demand. Firstly, the ecological water demand for agricultural irrigation of crops was calculated, and a radial basis function neural network (RBFNN) was constructed for predicting the water demand of agricultural irrigation. On this basis, an intelligent control strategy was presented for agricultural irrigation based on water demand prediction. The structure of the intelligent control system was fully clarified, and the main program was designed in detail. The proposed model was proved effective through experiments.