The effects of collagen peptides on exercise-induced gastrointestinal stress: a randomized, controlled trial

Abstract

Purpose We examined the effects of collagen peptides (CP) supplementation on exercise-induced gastrointestinal (GI) stress. Methods In a randomized, crossover design, 20 volunteers (16 males: $$\dot{V}$$ V ˙ O2max, 53.4 ± 5.9 ml·kg−1) completed 3 trials: a non-exercise rest trial, with no supplement (REST) and then an exercise trial with CP (10 g·day−1) or placebo control (CON) supplements, which were consumed for 7 days prior to, and 45 min before, a 70 min run at 70–90% of $$\dot{V}$$ V ˙ O2max. Outcome measures included urinary lactulose and rhamnose (L/R), intestinal fatty acid binding protein (I-FABP), lipopolysaccharide (LPS), anti-LPS antibody, monocyte-chemoattractant protein-1 (MCP-1), interleukin (IL) 6 and 8, cortisol, alkaline phosphatase (ALP) (measured pre, 10 min post and 2 h post) and subjective GI symptoms. Results There were no differences in heart rate, perceived exertion, thermal comfort, or core temperature during exercise in the CP and CON trials (all P > 0.05). I-FABP was higher in CP (2538 ± 1221 pg/ml) and CON (2541 ± 766 pg/ml) vs. REST 2 h post (1893 ± 1941 pg/ml) (both P < 0.05). LPS increased in CON vs. REST 2 h post (+ 71.8 pg/ml; P < 0.05). Anti-LPS antibody decreased in CON and CP vs. REST at post (both P < 0.05). There were no differences in MCP-1, IL-6, and IL-8 between the CP and CON trials (all P > 0.05), and no differences in L/R or GI symptoms between CON and CP (all P > 0.05). Conclusion Collagen peptides did not modify exercise-induced changes in inflammation, GI integrity or subjective GI symptoms but LPS was higher in CON 2 h post-exercise and thus future studies may be warranted.

Collagen peptide supplementation before bedtime reduces sleep fragmentation and improves cognitive function in physically active males with sleep complaints

“…On day 7, participants reported to the lab in the evening (≥ 16:00), had a venous blood and urine sample collected, consumed a telemetric temperature pill (E-celsius Performance Pill, Body Cap, France) and performed a battery of cognitive function tests. Although the timing of pill ingestion (1 – 12 h before) does not appear to interfere with the validity of the sensor [ 47 ], consistent with previous studies, we provided the pill 5–8 h before our first recording [ 46 , 48 ], to ensure passage from the stomach. These telemetric pills have been shown to have excellent reliability and validity [ 49 ] and are considered the industry standard for temperature monitoring [ 50 ].…”

“…The trial order was randomly generated using online software (Graphpad Prism, CA, US). We provided CP for 7 days as this duration of intake has previously been shown to positively influence physiological markers [ 42 , 46 ].…”

Impact of Collagen Peptide Supplementation in Combination with Long-Term Physical Training on Strength, Musculotendinous Remodeling, Functional Recovery, and Body Composition in Healthy Adults: A Systematic Review with Meta-analysis

“…It has been reported to attenuate superoxide production in neutrophil granulocytes [81] and may decrease the synthesis of pro-inflammatory mediators while inhibiting LPS-induced cytokine production [82]. Recently, CP's potential ability to reduce endotoxemia [measured via lipopolysaccharides (LPS)] after gastrointestinal stress induced by intense aerobic exercise has been demonstrated in humans [83]. A recent review also revealed hydrolyzed CP to have possible anti-inflammatory and chondroprotective effects in patients with osteoarthritis, but considerable limitations exist due to methodological disparities [84].…”