The effects of combined acamprosate and integrative behaviour therapy in the outpatient treatment of alcohol dependence: A randomized controlled trial

The efficacy of acamprosate and naltrexone in the treatment of alcohol dependence, Europe versus the rest of the world: a meta‐analysis

“…Nineteen studies were identified by the NICE guideline that met inclusion criteria and an additional three studies were identified for inclusion in the current review . The majority of these studies were conducted in European countries , with only four conducted outside Europe . A total of 2649 participants in the acamprosate group and 2587 participants in the placebo group were included in the meta‐analysis.…”

Acamprosate for treatment of alcohol dependence: mechanisms, efficacy, and clinical utility

“…Overall, most psychosocial interventions, including self-help, have been found to be effective in the treatment of alcohol dependence 7. However, the majority of patients experience a lapse within the first year following a psychosocial intervention,8,9 and there is growing evidence that combining psychosocial and pharmacological treatments may be an effective method for treating alcohol dependence 10–12…”

“…To address this gap we will briefly summarize each of the randomized trials that have been published since 2006. Most recently, acamprosate was combined with either integrative behavioral therapy or supportive counseling, and was compared with integrative behavioral therapy and placebo in a randomized, double-blind multisite study 12. A total of 371 individuals were randomized to one of the three treatments (acamprosate + behavioral therapy, acamprosate + supportive counseling, or placebo + behavioral therapy) administered for 6 months, and patients were followed for 3 and 6 months after discontinuation of treatment.…”

“…Some studies have found that individuals with a goal of total abstinence and those patients who are highly motivated may be more likely to benefit from acamprosate than from naltrexone or placebo, 37,53 while another study found that acamprosate worked better for individuals who were very frequent drinkers prior to starting treatment and less well for those individuals who had more days of abstinence prior to treatment 54. Another intriguing finding is that acamprosate does not appear to confer additional benefits when prescribed in combination with behavioral interventions,12, although there may be some benefit to providing a motivational intervention prior to starting treatment with acamprosate 53…”

Alkol Aşermesi, Glutamat ve Akamprosat / Alcohol Craving, Glutamate and Acamprosate

“…Psikososyal girişimler tek başına bir tedavi biçimi olarak önerilse de, WFSBP (World Federation of Societies of Biological Psychiatry) (68) gibi güncel tedavi kılavuzları, aşerme giderici ilaçlar gibi farmakolojik tedavilerin sadece profesyonel psikososyal destek ya da psikososyal terapi varlığında öneril-mesini tavsiye etmektedir (69).…”