2003
DOI: 10.1097/01.ju.0000091640.59812.83
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The Effects of Combined Androgen Blockade on Cognitive Function During the First Cycle of Intermittent Androgen Suppression in Patients With Prostate Cancer

Abstract: Although preliminary, these findings demonstrate that 9 months of combined androgen blockade resulted in a beneficial effect on verbal memory but adversely affected a measure of spatial ability. Intermittent androgen suppression for a period of 9 months in otherwise healthy men with prostate cancer may have beneficial and adverse effects on cognition that are selective.

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Cited by 137 publications
(134 citation statements)
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“…Additional clarification of the relationship between lower testosterone levels and poorer cognitive function can be sought from studies involving dynamic changes in testosterone levels. In men undergoing hormonal therapy for prostate cancer, suppression of endogenous testosterone synthesis and blockade of the androgen receptor resulted in a beneficial effect on verbal memory but an adverse effect on spatial ability in one study, 33 and visuomotor slowing and slowed reaction times in several attentional domains in another. 34 Discontinuation of treatment resulted in improved memory but not visuospatial abilities.…”
Section: Testosterone and Cognitive Function In Older Menmentioning
confidence: 93%
“…Additional clarification of the relationship between lower testosterone levels and poorer cognitive function can be sought from studies involving dynamic changes in testosterone levels. In men undergoing hormonal therapy for prostate cancer, suppression of endogenous testosterone synthesis and blockade of the androgen receptor resulted in a beneficial effect on verbal memory but an adverse effect on spatial ability in one study, 33 and visuomotor slowing and slowed reaction times in several attentional domains in another. 34 Discontinuation of treatment resulted in improved memory but not visuospatial abilities.…”
Section: Testosterone and Cognitive Function In Older Menmentioning
confidence: 93%
“…[21][22][23][24][25][26][27] All adverse events associated with perprotocol treatment are shown in Table S3 in the Supplementary Appendix. The early diagnosis of failure of definitive treatment, as determined according to the PSA level, subjects otherwise asymptomatic men to many years of androgen deprivation, adversely affecting their quality of life.…”
Section: Discussionmentioning
confidence: 99%
“…In that case, the study design does not control for the presence of prostate cancer and related issues that may impact cognitive function (e.g., psychological ramifications of diagnosis, fatigue, cancer treatments). We review three studies involving a healthy community control group [46][47][48] and two studies that an untreated patient control group. 13,49 Only one of these studies directly compared different ADT treatments, and treatment assignment was randomized in that study.…”
Section: Evidence For Cognitive Effects Of Testosteronementioning
confidence: 99%
“…40,42 Observational studies comparing patients versus healthy controls over time Cherrier et al 47 conducted a prospective observational study involving a group of 19 men with non-metastatic prostate cancer in biochemical relapse treated with intermittent ADT (I-ADT) and a group of 15 healthy men (mean age of groups: 65 years). Patients were treated for 2 weeks with flutamide (250 mg, three times daily) or bicalutamide (50 mg daily) if intolerant of flutamide followed by the addition of leuprolide (7.5 mg intramuscular) for a total of nine monthly doses.…”
Section: Adt and Cognitionmentioning
confidence: 99%