The effects of concomitant Ginkgo intake on noise induced Hippocampus injury. Possible auditory clinical correlate

Abousetta, Alaa; Makhlouf, Noha A.; El-Beshbishy, Rana A.

doi:10.1016/j.ejenta.2014.05.003

Cited by 4 publications

(5 citation statements)

References 24 publications

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“…The zona reticularis exhibited areas of diluted cytoplasm, disarranged endoplasmic reticulum, membrane vestigia and some altered mitochondria at all exposure times examined [25]. Also, these results were in line with the results of the authors who examined the injurious effects of white noise (100 dB) on the hippocampus [26]. The authors found that the Pyramidal neurons of the noise exposed group showed different stages of degeneration as darkened irregular shrunken cell bodies of cells.…”

Section: Discussionsupporting

confidence: 86%

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The possible protective effect of black seed (Nigella Sativa) oil on the testes of adult male albino rat exposed to noise

Mohamed¹,

Hanafy²,

Mahmoud³

2015

J Histol Histopathol

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The aim of this study is to investigate the effect of noise exposure on the histological structure of the adult male albino rat testes and evaluate the possible protective role of black seed (Nigella Sativa) oil on the histological structure of the adult male albino rat testes exposed to noise. This study was conducted to determine the injurious effects of noise on the testis and to show whether black seed oil has any modulatory effect on testicular injury. 40 adult male albino rats were divided into 4 groups. Group A (control group) was kept in an environment free from noise as control group. Group B was exposed to 95 dB of noise for 4 hours daily for duration of 45days. Group C was exposed to 95 dB of noise for 4 hours daily for duration of 45days and given orally black seed oil (5 ml/kg/day) during the period of noise exposure.Group D was kept in an environment free from noise and given orally black seed oil (5 ml/kg/day) for duration of 45days. Histological study was performed on the testes using light microscopy and Transmission electron microscopy (TEM). Morphometric study was done to measure the height of the spermatogenic cells. The result of the experiment revealed that the spermatogenic cells of group B appeared distorted. Most of the spermatogenic cells had vacuolated cytoplasm. Some of them had degenerated mitochondria and abnormal nuclei. Most of sperms were markedly affected. Their detailed structures couldn't be recognized. Group C showed preservation of the structure of the testes as compared to group B i.e., the spermatogenic cells became easily recognized and were arranged in rows along the basal lamina of the seminiferous tubules. They showed that most of the cytoplasmic vacuolations became absent but some mitochondria showed degeneration. Most of the nuclei of spermatogenic cells appeared similar to group A. There was significant decrease in the height of the spermatogenic cells in group B as compared to group A. In view of these findings, these data strongly suggest that noise stress had adverse effects on the testis of male albino rats. The administration of black seed oil protected the testis against the injurious effect of noise. The probable mechanism and usefulness of black seed oil in reducing the previously mentioned effects were possibly due to its antioxidant effects.

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Section: Discussionsupporting

confidence: 86%

“…The mitochondria were irregular and having disrupted cristae. Nuclear irregularities and extrusion of the nucleolus to the periphery were also detected [26].…”

Section: Discussionmentioning

confidence: 99%

The possible protective effect of black seed (Nigella Sativa) oil on the testes of adult male albino rat exposed to noise

Mohamed¹,

Hanafy²,

Mahmoud³

2015

J Histol Histopathol

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“…Some of these changes depend on the duration ( Barzegar et al, 2015 , Cheng et al, 2011 ) or level ( Hosseini-Sharifabad and Sabahi, 2008 , Matt et al, 2018 , Singer et al, 2013 ) of the noise, others can reverse over time ( Cui et al, 2012a , Di and Qin, 2018 , Frenzilli et al, 2017 ) or be protected against by various compounds ( Abousetta et al, 2014 , Alinaghipour et al, 2022 , Azman et al, 2016 , Li et al, 2014 , Sundaramahalingam et al, 2013 ; S. Wang et al, 2016 ) or exercise (T.-W. Kim et al, 2013 ). Many are not specific to sound, arising due to a range of stressors ( Chen et al, 2010 ; B.-K. Kim et al, 2013 ; Kim and Diamond, 2002 ).…”

Section: Long-term Experience With Sound and Its Absencementioning

confidence: 99%

The hearing hippocampus

Billig

Lad

Sedley

et al. 2022

Progress in Neurobiology

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“…Makhlouf et al (2014) reported a decrease in the thickness of pyramidal cell layer of CA1 (cornu ammonis area 1), CA3 (cornu ammonis area 3), and also the granular cell which exhibited degeneration and loss of many cells after exposure to 100 dB noise during 4 weeks (4h/day) in male albino rats (Makhlouf et al, 2014). Abousetta et al (2014) indicated that exposure to 100 dB white noise for 6 h/day during 4 consecutive weeks induced a decrease in thickness of dentate gyrus (DG) granular cell layer and pyramidal cell layer with the loss and degeneration of numerous cells in male albino rats (Abousetta et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Co-exposure to Toluene and Noise Made Synergistic and Antagonistic Effects on Some Neurotoxic Parameters in New Zealand White Rabbits

Abouee-Mehrizi

Rasoulzadeh

Mehdipour

et al. 2023

BCN

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Introduction: Numerous physical and chemical agents can induce destructive effects on the brain tissue. Noise and toluene, which are some of these harmful agents, have significant adverse effects on the brain tissue. This work aims to investigate the neurotoxic changes induced by co-exposure to toluene and noise. Methods: Totally, 24 male white New Zealand rabbits were randomly segregated into 4 groups including toluene exposure, noise exposure, co-exposure to noise and toluene, and control. This in-vivo study tested the neurotoxic effects of exposure to 1000 ppm toluene and 100 dB noise during two weeks (8 h/day). The serum levels of brain-derived neurotrophic factor-α (BDNF-α) and malondialdehyde (MDA), total antioxidant capacity (TAC), glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase levels in the brain tissue were measured. Moreover, hematoxylin and eosin staining was utilized for brain pathological analysis. Results: Exposure to noise increased TAC level in the cerebral cortex. Co- exposure to toluene and noise increased the serum level of BDNF-α. Nevertheless, exposure to noise decreased the level of BDNF-α in serum. On the other hand, hispathological examinations using hematoxylin-eosin (H&E) exhibited that different signs of inflammation such as lymphocyte infiltration, pyknosis, vacuolization, and chromatolysis were induced by exposure to noise and toluene in the cerebellum, hippocampus, and frontal section in the brain tissue. In addition, simultaneous exposure to toluene and noise induced antagonistic and synergistic changes on some neurotoxic parameters. Conclusion: Exposure to noise and toluene, which caused inflammation in the brain tissue cells, could be a noticeable risk factor for neurological system.

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The effects of concomitant Ginkgo intake on noise induced Hippocampus injury. Possible auditory clinical correlate

Cited by 4 publications

References 24 publications

The possible protective effect of black seed (Nigella Sativa) oil on the testes of adult male albino rat exposed to noise

The possible protective effect of black seed (Nigella Sativa) oil on the testes of adult male albino rat exposed to noise

The hearing hippocampus

Co-exposure to Toluene and Noise Made Synergistic and Antagonistic Effects on Some Neurotoxic Parameters in New Zealand White Rabbits

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