The effects of continuous cocaine duration on the induction of behavioral tolerance and dopamine autoreceptor function

King, George; Pinto, Gail; Konen, Jennifer; Hillburn, Craig; Tran, Sophie; Love, Wees; Cayse, Rachel; Castro, Gene

doi:10.1016/s0014-2999(02)01822-8

European Journal of Pharmacology

2002

DOI: 10.1016/s0014-2999(02)01822-8

|View full text |Cite

The effects of continuous cocaine duration on the induction of behavioral tolerance and dopamine autoreceptor function

George King

Gail Pinto

Jennifer Konen

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2002

2008

Publication Types

Select...

Article5

Relationship

Self Cite0

Independent5

Authors

Journals

Cited by 7 publications

(1 citation statement)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A likely possibility is that while MP may amplify the effects of relatively weak reinforcing stimuli it may not do so for stronger ones. However, because chronic cocaine has been associated with supersensitivity of DA D2 autoreceptors (Davidson et al, 2000;Jones et al, 1996;King et al, 2002), it is also possible that the slow and small DA increases induced by MP could be sufficient to inhibit DA release attenuating the "phasic" DA cell firing associated with the cues. Alternatively since prior imaging studies have shown decreased activity of DA neurons in cocaine abusers (Volkow et al, 1997;Martinez et al, 2007) failure to observe an amplification of the DA signal may reflect a ceiling effect.…”

mentioning

confidence: 99%

Dopamine increases in striatum do not elicit craving in cocaine abusers unless they are coupled with cocaine cues

et al. 2008

View full text Add to dashboard Cite

Imaging studies have shown an association between dopamine increases in striatum and cue induced craving in cocaine abusers. However, the extent to which dopamine increases reflect a primary rather than a secondary response to the cues remains unclear. Here we evaluated the extent to which dopamine increases by themselves can induce craving in cocaine abusers. Using PET and [ 11 C]raclopride (D2 receptor radioligand sensitive to competition with endogenous dopamine) we show that in cocaine abusers (n = 20) oral methylphenidate (20 mg), which significantly increased dopamine in striatum, did not induce craving unless subjects were concomitantly exposed to cocaine-cues (video scenes of subjects self-administering cocaine). This suggests that dopamine increases associated with conditioned-cues are not primary responses but reflect downstream stimulation of dopamine cells (presumably glutamatergic afferents from prefrontal cortex and/or amygdala). Inasmuch as afferent stimulation of dopamine neurons results in phasic cell firing these findings suggest that "fast" dopamine increases, in contrast to the "slow" dopamine increases as achieved when using oral methylphenidate (mimicking tonic dopamine cell firing), are required for cues to trigger craving. The fact that methylphenidate induced craving only when given with the cocaine-cues highlights the context dependency of methylphenidate's effects and suggests that its use for the treatment of ADHD subjects with co-morbid drug abuse should not increase craving. KeywordsPET imaging; raclopride; addiction; caudate; putamen; conditioned responses; D2 receptors In drug addicted subjects, exposure to places where they have taken the drug, to people with whom prior drug use occurred, or to paraphernalia used to administer the drug elicits intense * Correspondence: National Institute on Drug Abuse, 6001 Executive Boulevard, Room 5274, Bethesda, MD 20892, Tel. (301) Fax (301) 443-9127, nvolkow@nida.nih.gov . Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. NIH Public Access Author ManuscriptNeuroimage. Author manuscript; available in PMC 2011 September 9. is clinically relevant since it is a major contributor in the cycle of relapse in addiction (O'Brien et al., 1998). Dopamine (DA), which is a neurotransmitter involved with reward and with the prediction of reward (Schultz et al., 1997;Wise and Rompre, 1989), appears to be involved with cue-elicited drug craving. Indeed, in laboratory animals when neutral stimuli are paired with a rewarding drug they will, with repeated associations, acquire the ability to increase DA in n...

show abstract

mentioning

confidence: 99%

Dopamine increases in striatum do not elicit craving in cocaine abusers unless they are coupled with cocaine cues

et al. 2008

View full text Add to dashboard Cite

show abstract

Evidence of cross-tolerance between behavioural effects of nicotine and cocaine in mice

Desai

Terry

2003

Psychopharmacology

View full text Add to dashboard Cite

show abstract

Augmented behavioral response and enhanced synaptosomal calcium transport induced by repeated cocaine administration are decreased by calcium channel blockers

et al. 2007

View full text Add to dashboard Cite

Recent studies suggest that calcium influx via L-type calcium channels is necessary for psychostimulant-induced behavioral sensitization. In addition, chronic amphetamine upregulates subtype Cav1.2-containing L-type calcium channels. In the present studies, we assessed the effect of calcium channel blockers (CCBs) on cocaine-induced behavioral sensitization and determined whether the functional activity of L-type calcium channels is altered after repeated cocaine administration. Rats were administered daily intraperitoneal injections of either flunarizine (40 mg/kg), diltiazem (40 mg/kg) or cocaine (20 mg/kg) and the combination of the CCBs and cocaine for 30 days. Motor activities were monitored on Day 1, and every 6th day during the 30-day treatment period. Daily cocaine administration produced increased locomotor activity. Maximal augmentation of behavioral response to repeated cocaine administration was observed on Day 18. Flunarizine pretreatment abolished the augmented behavioral response to repeated cocaine administration while diltiazem was less effective. Measurement of tissue monoamine levels on Day 18 revealed cocaine-induced increases in DA and 5-HT in the nucleus accumbens. By contrast to behavioral response, diltiazem was more effective in attenuating increases in monoamine levels than flunarizine. Cocaine administration for 18 days produced increases in calcium uptake in synaptosomes prepared from the nucleus accumbens and frontal cortex. Increases in calcium uptake were abolished by flunarizine and diltiazem pretreatment. Taken together, the augmented cocaine-induced behavioral response on Day 18 may be due to increased calcium uptake in the nucleus accumbens leading to increased dopamine (DA) and serotonin (5-HT) release. Flunarizine and diltiazem attenuated the behavioral response by decreasing calcium uptake and decreasing neurochemical release.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

The effects of continuous cocaine duration on the induction of behavioral tolerance and dopamine autoreceptor function

Cited by 7 publications

References 28 publications

Dopamine increases in striatum do not elicit craving in cocaine abusers unless they are coupled with cocaine cues

Dopamine increases in striatum do not elicit craving in cocaine abusers unless they are coupled with cocaine cues

Evidence of cross-tolerance between behavioural effects of nicotine and cocaine in mice

Augmented behavioral response and enhanced synaptosomal calcium transport induced by repeated cocaine administration are decreased by calcium channel blockers

Contact Info

Product

Resources

About