The effects of copper on ionic regulation by the gills of the seawater-adapted flounder (Platichthys flesus L.)

Copper toxicity in cultured human skeletal muscle cells: the involvement of Na+/K+-ATPase and the Na+/Ca2+-exchanger

“…a tivity is comparable to the ECS() of the C u2+ -induced increase of |Na+]j. These values are of the same order of magnitude as described for preparations of brain [37], g I Is [35], kidney and blood vessels [ 201. Fourth, a gen eral increase of the membrane permeability is not probae, since the time courses for the rises of [Na+]j and C a2+| j are quite different.…”

Interactions between copper and cadmium modify metal organ distribution in mature tilapia, Oreochromis mossambicus

“…The metal accumulation in the intestinal wall might be a specific mechanism for tilapia, because in general in fish about 95% of the whole body Cu accumulation was allocated into the liver (Stagg and Shuttleworth, 1982;Laurrn and McDonald, 1987). Perhaps an efficient accumulation and excretion route via the intestine contributes to the metal tolerance of tilapia, which is higher than in other species studied.…”

“…This accumulation was concentration-and time-dependent, only for Cd. Increased metal concentrations were also observed in Cu-exposed carp, brown bullhead and roach (Yamamoto et al, 1977;Stagg and Shuttleworth, 1982;Segner, 1987) but not in rainbow trout (Laurrn and McDonald, 1987), and in Cd-exposed rainbow trout, pike and American eel (Brown et al, 1986;Norey et al, 1990;Gill et al, 1992). Metal-metal interactions after single metal exposure were shown by Gill et al (1992) who reported an increased Cu concentration in the gills of eels after Cd exposure.…”

“…Opposing effects have been reported in most other fish species. Cu has been shown to accumulate in both the liver and kidneys of catfish (Brungs et al, 1973) and carp (Yamamoto et al, 1977), whereas Stagg and Shuttleworth (1982) registered a decreased Cu concentration in the liver of flounder after Cu exposure in seawater. Starved, but not fed, roach accumulated significant amounts of Cu in the liver (Segner, 1987).…”

Copper acclimation in juvenile fathead minnows: Is a cycle of branchial damage and repair necessary?

“…The branchial damage can include: a reduction in Na + influx McDonald, 1985, 1987a) a stimulation of Na + efflux (Laurén and McDonald, 1985) and an inhibition of branchial Na + -K + ATPase activity (Stagg and Shuttleworth, 1982;Laurén and McDonald, 1987b;Pelgrom et al, 1995;Kolok et al, 2002). These branchial changes can lead to an increase in net Na + loss (Croke and McDonald, 2002;Taylor et al, 2004), which can culminate in a significantly reduced concentration of whole-body Na + (Laurén and McDonald, 1987a;McGeer et al, 2000;Kolok et al, 2002).…”