The Effects of Corticosteroid on Tissue Lactoferrin in Patients with Nasal Polyposis

Acıoğlu, Engin; Yiğit, Özgür; Alkan, Zeynep; Azizli, Elad; Gelişgen, Ramisa; Uzun, Hafize

doi:10.2500/ajra.2012.26.3735

Cited by 6 publications

(6 citation statements)

References 13 publications

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“…In this regard, evidence of the modulation of RT inflammation by bLf associated to certain microbes has been reported using several in vitro and in vivo models. Moreover, Lf is considered the second most important antimicrobial and anti-inflammatory peptide after lysozyme in the upper RT [174]. Tuberculosis is by far the most studied in vivo model of microbial pulmonary infection.…”

Section: Lactoferrin As Anti-inflammatory In Infectious Diseasesmentioning

confidence: 99%

Lactoferrin: Balancing Ups and Downs of Inflammation Due to Microbial Infections

Drago-Serrano

Campos-Rodrı́guez

Carrero

et al. 2017

IJMS

115

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Lactoferrin (Lf) is a glycoprotein of the primary innate immune-defense system of mammals present in milk and other mucosal secretions. This protein of the transferrin family has broad antimicrobial properties by depriving pathogens from iron, or disrupting their plasma membranes through its highly cationic charge. Noteworthy, Lf also exhibits immunomodulatory activities performing up- and down-regulation of innate and adaptive immune cells, contributing to the homeostasis in mucosal surfaces exposed to myriad of microbial agents, such as the gastrointestinal and respiratory tracts. Although the inflammatory process is essential for the control of invasive infectious agents, the development of an exacerbated or chronic inflammation results in tissue damage with life-threatening consequences. In this review, we highlight recent findings in in vitro and in vivo models of the gut, lung, oral cavity, mammary gland, and liver infections that provide experimental evidence supporting the therapeutic role of human and bovine Lf in promoting some parameters of inflammation and protecting against the deleterious effects of bacterial, viral, fungal and protozoan-associated inflammation. Thus, this new knowledge of Lf immunomodulation paves the way to more effective design of treatments that include native or synthetic Lf derivatives, which may be useful to reduce immune-mediated tissue damage in infectious diseases.

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Section: Lactoferrin As Anti-inflammatory In Infectious Diseasesmentioning

confidence: 99%

Lactoferrin: Balancing Ups and Downs of Inflammation Due to Microbial Infections

Drago-Serrano

Campos-Rodrı́guez

Carrero

et al. 2017

IJMS

115

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“…Systemic corticosteroid treatment induced the most apoptosis. Low The effects of corticosteroid on tissue lactoferrin in patients with nasal polyposis [ 68 ] Acıoğlu 2012 Prospective 41 1 mg/kg/day oral methylprednisolone decreasing by 10 mg every 3rd day. Not mentioned.…”

Section: Resultsmentioning

confidence: 99%

Systemic corticosteroids in treatment of chronic rhinosinusitis—A systematic review

Tamene,

Dalhoff,

Schwarz

et al. 2023

European Clinical Respiratory Journal

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Purpose When first-line chronic rhinosinusitis (CRS) treatment fails, patients can either be treated with oral or injected systemic corticosteroids. Although the EPOS and international guidelines for CRS do not mention injected corticosteroids, it is commonly used by ear, nose, and throat specialists. While the risks of systemic corticosteroids, in general, are known, the pros and cons of injected and oral corticosteroids (OCS) in CRS treatment are unclear. Methods A systematic review of studies that report the effects and/or side effects of injected and oral corticosteroids in the treatment of CRS was made according to the PRISMA guidelines. Results Altogether, 48 studies were included, only five studies reported on injected corticosteroids, and five attended with side effects. Three studies found beneficial effects of OCS perioperatively on sinus surgery, while four articles found no effect. Nineteen articles reported that OCS resulted in an improvement in symptoms. Two articles presented a longer-lasting effect of injected corticosteroids than OCS. Three studies reported adverse side effects of systemic corticosteroids, while two studies showed no adverse side effects. One study showed less adrenal suppression after injected corticosteroids compared to OCS. The evidence is not strong but shows a positive effect of systemic corticosteroids that lasts longer with injections. Conclusion Although systemic corticosteroids are widely used to treat CRS, there is a lack of studies comparing the OCS and injected corticosteroids. The evidence is sparse, however, injected steroids show longer effects with fewer side effects. An RCT study is needed to compare OCS and injected corticosteroids.

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“…Lf, together with Ly, is the most important antimicrobial and anti-inflammatory protein of the upper respiratory tract. As demonstrated, patients affected by chronic rhinosinusitis with nasal polyposis show lower lf levels [ 59 ]. Wang et al investigated the effect of intranasal administration of hlf in mice with allergic rhinitis (AR), showing a reduction of Th2 inflammation and symptoms, suggesting that the use of lf might be effective for the prevention and treatment AR [ 60 ].…”

Section: Resultsmentioning

confidence: 99%

Lactoferrin: Cytokine Modulation and Application in Clinical Practice

Presti

Manti

Parisi

et al. 2021

JCM

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Multiple properties of lactoferrin have been reported in the literature so far. Decades of in vitro and in vivo studies have demonstrated the important antimicrobial, anti-inflammatory, anti-oxidant, and immunomodulating properties. It suggests the use of lactoferrin as an effective and safe option for the treatment of several common disorders. Herein, we show the applications of lactoferrin in clinical practice, highlighting its evidence-based capacities for the treatment of heterogeneous disorders, such as allergic, gastrointestinal, and respiratory diseases, and hematologic, oncologic, gynecologic, dermatologic, and dental disorders. Moreover, the widespread use of lactoferrin in neonatology is summarized here. As a result of its antiviral properties, lactoferrin has also been proposed as a valid option for the treatment for COVID-19 patients. Here, the uses of lactoferrin in clinical practice as a new, safe, and evidence-based treatment for many types of disorders are summarized.

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The Effects of Corticosteroid on Tissue Lactoferrin in Patients with Nasal Polyposis

Cited by 6 publications

References 13 publications

Lactoferrin: Balancing Ups and Downs of Inflammation Due to Microbial Infections

Lactoferrin: Balancing Ups and Downs of Inflammation Due to Microbial Infections

Systemic corticosteroids in treatment of chronic rhinosinusitis—A systematic review

Lactoferrin: Cytokine Modulation and Application in Clinical Practice

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