The effects of corticosterone on 5-HT receptor function in rodents

Young, Allan H.; MacDonald, L.M.; John, Linu M.; Dick, H.; Goodwin, Guy M.

doi:10.1016/0028-3908(92)90080-9

Cited by 59 publications

(26 citation statements)

References 23 publications

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“…Putative postsynaptic 5-HT mediated behaviour (forepaw treading) is reduced by corticosteroid administration in rodents (Haleem 1992). Chronic administration of corticosterone also causes a reduction in the function and binding of somato-dendritic 5-HT 1A receptor (Young et al 1992;Laaris et al 1995). It should be noted, however, that stress initially produces a transient increase in post synaptic 5-HT 1A receptors (Mendelson and McEwen 1991) which is not in keeping with the Þndings in this study.…”

Section: Discussioncontrasting

confidence: 49%

5-Hydroxytryptamine receptor function in humans is reduced by acute administration of hydrocortisone

et al. 1998

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5-Hydroxytryptamine1A (5-HT1A) receptors have been shown to be suppressed by corticosteroid hormones in a variety of animal experimental paradigms. It has been suggested that this effect may be central to the pathophysiology of severe clinical depressive illness, a condition in which 5-HT1A receptor function is reduced and corticosteroid hormones are elevated. We report the effects of acute administration of hydrocortisone in normal volunteers on a neuroendocrine model of 5-HT1A receptor function. Fifteen healthy male volunteers took part in a random order, double blind, placebo controlled study, in which 100 mg hydrocortisone or placebo was administered 11 h before infusion of L-tryptophan (L-TRP). Pre-treatment with hydrocortisone significantly reduced the growth hormone (GH), but not the prolactin (PRL) response to the infusion. These data are consistent with the view that acute administration of corticosteroid hormones significantly impairs 5-HT1A receptor mediated function in healthy human volunteers and are in line with animal studies of the effects of corticosteroid hormones on 5-HT1A receptors. We propose that this finding is relevant to the pathophysiological processes which cause severe depressive illness.

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Section: Discussioncontrasting

confidence: 49%

5-Hydroxytryptamine receptor function in humans is reduced by acute administration of hydrocortisone

et al. 1998

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“…While long-term glucocorticoid treatment sensitizes DOI-induced wet-dog shakes and desensitizes 8-OH-DPAT-mediated hypothermia, no changes in the lethality of DOI have ever been documented following this treatment Matuszewich and Yamamoto, 2003 ;Takao et al, 1997). However, it should be noted that 10-d treatment with corticosterone has been documented to enhance the induction of 5-HT syndrome in response to carbidopa and 5-hydroxytryptophan, demonstrating that glucocorticoids do possess the ability to sensitize the induction of 5-HT syndrome (Young et al, 1992). Ultimately, the possibility exists that in addition to altering either receptor level or sensitivity, prolonged cannabinoid treatment probably modifies other parameters of the 5-HT system.…”

Section: Discussionmentioning

confidence: 93%

Altered responsiveness of serotonin receptor subtypes following long-term cannabinoid treatment

Hill¹,

Sun²,

Tse³

et al. 2005

Int. J. Neuropsychopharm.

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This study examined the effects of long-term cannabinoid administration on the responsivity of 5-HT 1A and 5-HT 2A receptors, which have been implicated in depression. Animals received 12 d administration of the potent cannabinoid receptor agonist HU-210 (100 mg/kg), following which they were monitored on their behavioural, physiological and hormonal responses to a single challenge of a 5-HT 1A and 5-HT 2A receptor agonist, 8-OH-DPAT (0.3 mg/kg) and DOI (1 mg/kg) respectively. Chronic HU-210 treatment lead to a significant enhancement of DOI-induced wet-dog shakes, but a reduction of DOI-induced back muscle contractions. DOI-induced corticosterone release was unaffected by HU-210 treatment. The hyperthermic response to DOI appeared to be potentiated by long-term HU-210 treatment, as 50 % of these subjects died from an apparent serotonin syndrome with core temperatures exceeding 43 xC. The 8-OH-DPAT-induced hypothermic response and elevation of corticosterone were both significantly attenuated by long-term HU-210 treatment. These data imply that chronic cannabinoid treatment may up-regulate 5-HT 2A receptor activity while concurrently down-regulating 5-HT 1A receptor activity, a finding similar to that sometimes observed in depression. This may partially explain the association between excessive cannabis consumption and the induction of affective disease.

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“…In fact, a reciprocal relationship between the serotonergic system and the hypothalamic-pituitary-adrenal (HPA) axis has been hypothesized. An increase in glucocorticoid activity has been associated with an increase in serotonin turnover [7], an increase in the number and sensitivity of 5-HT 2 receptors in the frontal cortex [8], and a desensitisation of 5-HT 1A receptors [9,10]. Inversely, a stimulation of the serotonergic function modifies the activity of the HPA axis [11].…”

Section: Introductionmentioning

confidence: 99%

HPA Axis Dysfunction in Major Depression: Relationship to 5-HT<sub>1A</sub> Receptor Activity

Pitchot

Herrera²,

Ansseau

2001

Neuropsychobiology

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Major depression is associated with a dysfunction of the serotonergic activity and the hypothalamic-pituitary- adrenal (HPA) axis. Moreover, a reciprocal relationship between the serotonergic and HPA axis systems has been hypothesized. The purpose of the present study was to assess the relationship between sensitivity of 5-HT_1A receptors as measured by hormonal (ACTH, cortisol and PRL) and temperature responses to flesinoxan and HPA axis activity as measured by the dexamethasone suppression test. The sample included 21 inpatients with major depression. Dexamethasone nonsuppressors exhibited lower ACTH responses to flesinoxan as compared with dexamethasone suppressors. The results showed that a dysfunction in 5-HT_1A receptor activity could be due to a hypersecretion of cortisol.

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The effects of corticosterone on 5-HT receptor function in rodents

Cited by 59 publications

References 23 publications

5-Hydroxytryptamine receptor function in humans is reduced by acute administration of hydrocortisone

5-Hydroxytryptamine receptor function in humans is reduced by acute administration of hydrocortisone

Altered responsiveness of serotonin receptor subtypes following long-term cannabinoid treatment

HPA Axis Dysfunction in Major Depression: Relationship to 5-HT<sub>1A</sub> Receptor Activity

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