1988
DOI: 10.1210/endo-123-2-713
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The Effects of Cortisol, Vasopressin (AVP), and Corticotropin-Releasing Factor Administration on Pulsatile Adrenocorticotropin, α-Melanocyte-Stimulating Hormone, and AVP Secretion in the Pituitary Venous Effluent of the Horse*

Abstract: Plasma ACTH, arginine vasopressin (AVP), and alpha MSH were measured in pituitary venous effluent at 5-min intervals from five unanesthetized horses during cortisol infusion and after an iv bolus of AVP or ovine (o) CRF. In control experiments (no hormone) there was a significant overall correlation between the timing of concentration changes in ACTH and alpha MSH. Cortisol infusion increased jugular cortisol levels by 70% and was associated with a reduction in mean ACTH, AVP, and alpha MSH secretion rates and… Show more

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Cited by 38 publications
(27 citation statements)
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“…From a mechanistic vantage, a plausible postulate is that daytime hypocortisolemia evokes more rapid initial ACTH secretion by potentiating corticotrope exocytosis of prestored hormone. This hypothesis would accommodate putatively greater nighttime accumulation of releasable ACTH stores under low glucocorticoid feedback followed by enhanced daytime stimulation of ACTH release by CRH and/or AVP (2,4,8,12,24,25,30,32,40,41). Physiological control of pituitary-hormone secretoryburst shape is also evident in relation to pulsatile LH release assessed at different stages of the normal menstrual cycle (16).…”
Section: Discussionmentioning
confidence: 99%
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“…From a mechanistic vantage, a plausible postulate is that daytime hypocortisolemia evokes more rapid initial ACTH secretion by potentiating corticotrope exocytosis of prestored hormone. This hypothesis would accommodate putatively greater nighttime accumulation of releasable ACTH stores under low glucocorticoid feedback followed by enhanced daytime stimulation of ACTH release by CRH and/or AVP (2,4,8,12,24,25,30,32,40,41). Physiological control of pituitary-hormone secretoryburst shape is also evident in relation to pulsatile LH release assessed at different stages of the normal menstrual cycle (16).…”
Section: Discussionmentioning
confidence: 99%
“…38). Median ages were 39 (range 24-48) yr in women and 51 yr in men, and body mass indexes 27 (23)(24)(25)(26)(27)(28)(29)(30)(31) kg/m 2 and 25 (21)(22)(23)(24)(25)(26)(27)(28)(29) kg/m 2 , respectively. Participants maintained conventional work and sleeping patterns and reported no recent (within 10 days) transmeridian travel, weight loss or gain, intercurrent psychosocial stress, prescription medication use, substance abuse, neuropsychiatric illness, or systemic disease.…”
Section: Clinical Protocolmentioning
confidence: 99%
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“…Similar observations were made using 5-min sampling of PV blood from unperturbed horses [29] and from those undergoing hypoglycemia [29], cortisol infu sion [30] and hyperosmolality [25]. Intensive sampling of PV blood from horses during vigorous exercise [15] or hypocortisolemia [17] also shows close coupling between AVP and ACTH secretion.…”
Section: Discussionmentioning
confidence: 65%
“…The adrenal axis is interesting because there are several hypothalamic hormones that act on the corticotropes. Two hypothalamic hormones have been shown to stimulate ACTH secretion in horses, corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) [8,18]. CRH also acts within the brain to alter behavior, increasing arousal, anxiety and depressing appetite [19].…”
Section: What Hormonal Changes Occur Duringmentioning
confidence: 99%