The effects of CRF and the urocortins on the hippocampal acetylcholine release in rats

Pintér, Dávid; Balangó, Beáta; Simon, Balázs; Palotai, Miklós; Csabafi, Krisztina; Dobó, Endre; Ibos, Katalin Eszter; Bagosi, Zsolt

doi:10.1016/j.npep.2021.102147

Cited by 3 publications

(1 citation statement)

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“…ACTH and glucocorticoids), elevated hippocampal ACh efflux in a time‐ and dose‐dependent manner (Day et al, 1998; Desvignes et al, 2003). Likewise, local application of CRF receptor agonists increased cholinergic transmission from superfused hippocampal slices isolated from rats (Pinter et al, 2021). CRF exerts neuromodulatory effects of stress on cognition via interactions with various neurotransmitter systems including the cholinergic system (Bangasser & Kawasumi, 2015; Hupalo et al, 2019).…”

Section: Stress and Cholinergic Shpmentioning

confidence: 99%

Septohippocampal cholinergic system at the intersection of stress and cognition: Current trends and translational implications

Kniffin

Bangasser

Parikh

2023

Eur J of Neuroscience

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Deficits in hippocampus‐dependent memory processes are common across psychiatric and neurodegenerative disorders such as depression, anxiety and Alzheimer's disease. Moreover, stress is a major environmental risk factor for these pathologies and it exerts detrimental effects on hippocampal functioning via the activation of hypothalamic–pituitary–adrenal (HPA) axis. The medial septum cholinergic neurons extensively innervate the hippocampus. Although, the cholinergic septohippocampal pathway (SHP) has long been implicated in learning and memory, its involvement in mediating the adaptive and maladaptive impact of stress on mnemonic processes remains less clear. Here, we discuss current research highlighting the contributions of cholinergic SHP in modulating memory encoding, consolidation and retrieval. Then, we present evidence supporting the view that neurobiological interactions between HPA axis stress response and cholinergic signalling impact hippocampal computations. Finally, we critically discuss potential challenges and opportunities to target cholinergic SHP as a therapeutic strategy to improve cognitive impairments in stress‐related disorders. We argue that such efforts should consider recent conceptualisations on the dynamic nature of cholinergic signalling in modulating distinct subcomponents of memory and its interactions with cellular substrates that regulate the adaptive stress response.

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Section: Stress and Cholinergic Shpmentioning

confidence: 99%

Septohippocampal cholinergic system at the intersection of stress and cognition: Current trends and translational implications

Kniffin

Bangasser

Parikh

2023

Eur J of Neuroscience

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In vitro and in vivo study of butyrylfentanyl and 4‐fluorobutyrylfentanyl in female and male mice: Role of the CRF₁ receptor in cardiorespiratory impairment

Bilel,

Azevedo Neto,

Tirri

et al. 2024

British J Pharmacology

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Background and PurposeFentanyl analogues have been implicated in many cases of intoxication and death with overdose worldwide. The aim of this study is to investigate the pharmaco‐toxicology of two fentanyl analogues: butyrylfentanyl (BUF) and 4‐fluorobutyrylfentanyl (4F‐BUF).Experimental ApproachIn vitro, we measured agonist opioid receptor efficacy, potency, and selectivity and ability to promote interaction of the μ receptor with G protein and β‐arrestin 2. In vivo, we evaluated thermal antinociception, stimulated motor activity and cardiorespiratory changes in female and male CD‐1 mice injected with BUF or 4F‐BUF (0.1–6 mg·kg−1). Opioid receptor specificity was investigated using naloxone (6 mg·kg−1). We investigated the possible role of stress in increasing cardiorespiratory toxicity using the corticotropin‐releasing factor 1 (CRF1) antagonist antalarmin (10 mg·kg−1).Key ResultsAgonists displayed the following rank of potency at μ receptors: fentanyl > 4F‐BUF > BUF. Fentanyl and BUF behaved as partial agonists for the β‐arrestin 2 pathway, whereas 4F‐BUF did not promote β‐arrestin 2 recruitment. In vivo, we revealed sex differences in motor and cardiorespiratory impairments but not antinociception induced by BUF and 4F‐BUF. Antalarmin alone was effective in blocking respiratory impairment induced by BUF in both sexes but not 4F‐BUF. The combination of naloxone and antalarmin significantly enhanced naloxone reversal of the cardiorespiratory impairments induced by BUF and 4F‐BUF in mice.Conclusion and ImplicationsIn this study, we have uncovered a novel mechanism by which synthetic opioids induce respiratory depression, shedding new light on the role of CRF1 receptors in cardiorespiratory impairments by μ agonists.

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Progress in research of corticotropin-releasing hormone receptor 2 in inflammatory bowel disease

Liu,

Jin,

Fan

2024

WCJD

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The effects of CRF and the urocortins on the hippocampal acetylcholine release in rats

Cited by 3 publications

References 42 publications

Septohippocampal cholinergic system at the intersection of stress and cognition: Current trends and translational implications

Septohippocampal cholinergic system at the intersection of stress and cognition: Current trends and translational implications

In vitro and in vivo study of butyrylfentanyl and 4‐fluorobutyrylfentanyl in female and male mice: Role of the CRF₁ receptor in cardiorespiratory impairment

Progress in research of corticotropin-releasing hormone receptor 2 in inflammatory bowel disease

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The effects of CRF and the urocortins on the hippocampal acetylcholine release in rats

Cited by 3 publications

References 42 publications

Septohippocampal cholinergic system at the intersection of stress and cognition: Current trends and translational implications

Septohippocampal cholinergic system at the intersection of stress and cognition: Current trends and translational implications

In vitro and in vivo study of butyrylfentanyl and 4‐fluorobutyrylfentanyl in female and male mice: Role of the CRF1 receptor in cardiorespiratory impairment

Progress in research of corticotropin-releasing hormone receptor 2 in inflammatory bowel disease

Contact Info

Product

Resources

About

In vitro and in vivo study of butyrylfentanyl and 4‐fluorobutyrylfentanyl in female and male mice: Role of the CRF₁ receptor in cardiorespiratory impairment