The Effects of Critical Illness on Intestinal Glucose Sensing, Transporters, and Absorption*

Deane, Adam M.; Rayner, Christopher K.; Keeshan, Alex; Cvijanovic, Nada; Marino, Zelia; Nguyen, Nam Q.; Chia, Bridgette; Summers, Matthew J.; Sim, Jennifer A.; Beek, Theresia van; Chapman, Marianne J.; Horowitz, Michael; Young, Richard L.

doi:10.1097/ccm.0b013e318298a8af

Cited by 78 publications

(73 citation statements)

References 40 publications

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“…Early SPN commencement revealed similar rates of achievement of the target calorie intake, mortality, and discharge in the EN group. This appears in agreement with the statement that commencing early SPN is not associated with improved clinical outcome in terms of reduced mortality or hospital LOS, while it improves the provision of calories and promotes the achievement of energy targets, leading to a more optimal intake of calories to avoid further energy deficit in critically ill patients when full enteral support fails to achieve calorie targets (3,9,11,(18)(19)(20)(21)(22)(23).…”

Section: Discussionsupporting

confidence: 89%

Importance of target calorie intake in hospitalized patients

Harmandar

Gömceli²,

Yolcular³

et al. 2020

Turk J Gastroenterol

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Section: Discussionsupporting

confidence: 89%

Importance of target calorie intake in hospitalized patients

Harmandar

Gömceli²,

Yolcular³

et al. 2020

Turk J Gastroenterol

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“…Our group has reported that fasting and postprandial concentrations of CCK and PYY are elevated in the critically ill, particularly in patients intolerant to intragastric feed 4 . Conversely, the rate of gastric emptying is a determinant of CCK and PYY secretion in the critically ill, as it is in health 5,9,10 . Hence, there is evidence of disordered gastrointestinal hormone secretion in the critically ill, which may contribute to delayed gastric emptying.…”

Section: Introductionmentioning

confidence: 99%

Endogenous amylin and glucagon-like peptide-1 concentrations are not associated with gastric emptying in critical illness

Summers

Bartolomeo

Zaknic

et al. 2014

Acta Anaesthesiol Scand

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“…There are a number of possible reasons for this. Although the mechanisms underlying impaired glucose absorption in critical illness are uncertain, they are likely to be multifaceted, with factors including the rate of gastric emptying, intestinal transit time, duodenal and/or jejunal flow events [3,6], the integrity of surface villi and the presence and function of sodium-glucose active transport molecules on intestinal enterocytes [4,38]. In the setting of these multifactorial influences, our results suggest that citrulline concentration may not be sufficiently sensitive to indicate carbohydrate malabsorption or reflect the absorptive capacity of the small intestine.…”

Section: Discussionmentioning

confidence: 99%

The relationship between fasting plasma citrulline concentration and small intestinal function in the critically ill

et al. 2015

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IntroductionIn this study, we aimed to evaluate whether fasting plasma citrulline concentration predicts subsequent glucose absorption in critically ill patients.MethodsIn a prospective observational study involving 15 healthy and 20 critically ill subjects, fasting plasma citrulline concentrations were assayed in blood samples immediately prior to the administration of a liquid test meal (1 kcal/ml; containing 3 g of 3-O-methylglucose (3-OMG)) that was infused directly into the small intestine. Serum 3-OMG concentrations were measured over the following 4 hours, with the area under the 3-OMG concentration curve (AUC) calculated as an index of glucose absorption.ResultsThe groups were well matched in terms of age, sex and body mass index (BMI) (healthy subjects versus patients, mean (range) values: age, 47 (18 to 88) versus 49 (21 to 77) years; sex ratio, 60% versus 80% male; BMI, 25.2 (18.8 to 30.0) versus 25.5 (19.4 to 32.2) kg/m2). Compared to the healthy subjects, patients who were critically ill had reduced fasting citrulline concentration (26.5 (13.9 to 43.0) versus 15.2 (5.7 to 28.6) μmol/L; P < 0.01) and glucose absorption (3-OMG AUC, 79.7 (28.6 to 117.8) versus 61.0 (4.5 to 97.1) mmol/L/240 min; P = 0.05). There was no relationship between fasting citrulline concentration and subsequent glucose absorption (r = 0.28; P = 0.12).ConclusionsWhereas both plasma citrulline concentrations and glucose absorption were reduced in critical illness, fasting plasma citrulline concentrations were not predictive of subsequent glucose absorption. These data suggest that fasting citrulline concentration does not appear to be a marker of small intestinal absorptive function in patients who are critically ill.

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The Effects of Critical Illness on Intestinal Glucose Sensing, Transporters, and Absorption*

Cited by 78 publications

References 40 publications

Importance of target calorie intake in hospitalized patients

Importance of target calorie intake in hospitalized patients

Endogenous amylin and glucagon-like peptide-1 concentrations are not associated with gastric emptying in critical illness

The relationship between fasting plasma citrulline concentration and small intestinal function in the critically ill

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