The effects of cryotherapy on pain and function in individuals with knee osteoarthritis: a systematic review of randomized controlled trials

Dantas, Lucas Ogura; Moreira, Roberta de Fátima Carreira; Norde, Flavia Maintinguer; Serrao, P.R. Mendes Silva; Alburquerque‐Sendín, Francisco; Salvini, Tania F.

doi:10.1177/0269215519840406

Cited by 22 publications

(16 citation statements)

References 23 publications

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“…2). Supplemental searches were performed to expand on key topics identified in the original literature search, i.e., subchondral bone pathology [1], knee sleeves [2][3][4][5][19][20][21], bone marrow lesions [22][23][24][25][26], clinical risk factors for knee OA progression [27][28][29][30][31][32][33], OA phenotypes [34], nonpharmacological treatments for OA [35][36][37][38][39][40][41][42][43], and clinical practice guidelines for OA management [44].…”

Section: Literature Searchmentioning

confidence: 99%

“…According to our proposed clinical model, cryotherapy might be expected to alleviate pain by temporarily reducing blood flow to joint tissues. A systematic review of RCTs identified insufficient primary studies to draw conclusions about the effectiveness of cryotherapy on pain and physical function on individuals with knee osteoarthritis [40]. However, a review of cryotherapy treatment after unicompartmental and total knee arthroplasty concluded that continuous circulating cold flow might be optimal for pain relief and minimization of pain medication use after knee arthroplasty [41].…”

Section: Cryotherapy and Heatmentioning

confidence: 99%

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Comparison of 8-year knee osteoarthritis progression in 2 siblings: a case-based review

Gourlay

2020

Clin Rheumatol

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Because the pathophysiology of knee osteoarthritis is poorly understood, optimal evidence-based clinical management is uncertain. Sibling comparison studies can help inform a clinical model to guide preventive care. We compared the 8-year clinical outcomes in 2 sisters with a family history of osteoarthritis, normal BMI, and absence of knee pain at baseline. Both patients had Kellgren–Lawrence grade 1 in the affected knee at the time of twisting knee injuries leading to osteoarthritis diagnoses at age 50 (patient 1) and 51 (patient 2). Patient 1 developed a chronic right knee effusion, and progressed to Kellgren–Lawrence grade 3 bilaterally by the time she had a right total knee replacement at age 58. Patient 2 had subchondral fractures of the right knee with transient effusion, which healed after 1 year of partial weight-bearing with crutches and subsequent daily use of knee sleeves. Patient 2 had Kellgren–Lawrence grade 0 bilaterally upon surveillance imaging at age 58. The terms “osteoarthritis and knee and diagnostic imaging and subchondral bone and pathophysiology” were searched in the PubMed database to identify original research articles to inform a clinical model consistent with the patients’ outcomes. A fluid model of osteoarthritis was the best explanatory model for the discordant clinical trajectories of the age-matched siblings. Patient recommendations are presented based on these findings.

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Section: Literature Searchmentioning

confidence: 99%

Section: Cryotherapy and Heatmentioning

confidence: 99%

Comparison of 8-year knee osteoarthritis progression in 2 siblings: a case-based review

Gourlay

2020

Clin Rheumatol

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“…Since the random-effects model incorporates both within- and between-study variance, it is better suited than the fixed-effects model. The treatment effects were further classified as small (< 0.20), moderate (0.21 to 0.79), and large (> 0.80) according to Cohen’s criteria [ 36 ]. Heterogeneity was investigated using the chi square test.…”

Section: Methodsmentioning

confidence: 99%

Effect of exercise and/or educational interventions on physical activity and pain in patients with hip/knee osteoarthritis: A systematic review with meta-analysis

et al. 2022

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Objective To investigate the effectiveness of exercise and/or educational intervention on physical activity and pain in patients with hip/knee osteoarthritis (OA) using systematic review and meta-analysis. Methods We searched randomized controlled trials that investigated physical activity and pain and compared exercise and/or educational intervention with usual care in patients with hip/knee OA in MEDLINE (PubMed), ProQuest, Scopus, and the Physiotherapy Evidence Database (PEDro), including all those published by April 30, 2022 and written in English. Studies that newly applied analgesics after onset of the intervention were excluded. The revised Cochrane risk-of-bias tool for randomized trials was used to assess the methodological qualities. The random-effects model was used for meta-analysis with standard mean differences using RevMan version 5.4. The body of evidence for each study was synthesized using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach. Results Twenty studies including 2,350 patients were included (7 exercise studies, 8 educational intervention studies and 5 combination studies). The meta-analysis demonstrated that there is very low evidence that combination therapy of exercise and educational intervention improve the physical activity level at the endpoint (4 articles; SMD 0.33, 95% CI 0.04 to 0.51, P = 0.03). Low evidence was observed for combination therapy reducing pain (4 articles; SMD -0.15, 95% CI -0.29 to -0.02, P = 0.03). Discussion The current evidence indicated that combination therapy of exercise and educational intervention leads to improved physical activity and pain reduction in hip/knee OA patients, but the risk of bias in each study, especially in allocation concealment, downgraded the evidence level. These findings support the use of a combination therapy of exercise and educational intervention to promote physical activity levels in patients with hip/knee OA. Trail registration There was no financial support for this research. The protocol was registered at the International Prospective Register of Systematic Reviews (registration code: CRD42020205804).

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“…The use of thermal modalities including cold and heat therapy is not backed by any evidence [11]. Patients may prefer to receive heat, cold, or contrast treatments to reduce pain and enhance physical function, according to study [12].…”

Section: Thermal Modalitiesmentioning

confidence: 99%

Cartilage of Knee: Anatomy, Function and Recent Conservative Treatments

Ding¹

2023

HSET

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Damage to the knee's cartilage, notably the menisci, is thought to be a substantial contributor to musculoskeletal morbidity. The unique anatomical, biomechanical, and functional properties of knee cartilage make it vulnerable to injury and destruction. Knee cartilage is essential for both everyday use and long-term health. Due to its importance and its injury susceptibility, treatment toward this injury also is important. Considering the contraindications of surgery and the requirements of anesthesia, and the characteristics of the disease in the age distribution, surgery might unsuitable for some people then conservative treatment is worth consider. The purpose of this review is to summarize and analyze recent conservative treatment toward the injury of cartilage in knee and some of the current developments in order to search for the future target. By analyzing several conservative treatments, including pharmacotherapy, physical therapy, Kinesio tape and tissue engineering, it can be clear that conservative treatments have significant effect on symptoms and part of its function but can hardly rebuild its structure and all physiological functions.

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The effects of cryotherapy on pain and function in individuals with knee osteoarthritis: a systematic review of randomized controlled trials

Cited by 22 publications

References 23 publications

Comparison of 8-year knee osteoarthritis progression in 2 siblings: a case-based review

Comparison of 8-year knee osteoarthritis progression in 2 siblings: a case-based review

Effect of exercise and/or educational interventions on physical activity and pain in patients with hip/knee osteoarthritis: A systematic review with meta-analysis

Cartilage of Knee: Anatomy, Function and Recent Conservative Treatments

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