The effects of curcumin-containing supplementations on inflammatory markers and lipid profiles in patients with chronic kidney diseases: a systematic review and meta-analysis of randomized controlled trials

Abstract

Objectives An evaluation the effects of curcumin on inflammatory markers and lipid profiles among patients with chronic kidney diseases (CKD). Methods The electronic databases such as PubMed, and Scopus were searched systematically up until 12 December 2021. To evaluate the quality of the included studies, the Cochrane risk-of-bias tool for randomized trials was utilized. Likewise, data pooling was performed using a random effects model, also called a variance components model. Also, the findings were calculated as weighted mean difference (WMD) with a 95% confidence interval (CI). Results In the end, this meta-analysis comprised a total number of nine studies. Curcumin intake significantly reduced total cholesterol (TC) (WMD=−13.77 mg/dL; 95% CI, −26.77, −0.77; p=0.04) and tumor necrosis factor alpha (TNF-α) (WMD=−18.87 pg/mL; 95% CI, −28.36, −9.38; p<0.001) compared with controls. The results did not confirm the significant effect of curcumin intake on triglyceride (TG) (WMD=−6.37 mg/dL; 95% CI, −26.59, 13.85; p=0.54), low-density lipoproteins (LDL-C) (WMD=−5.65 mg/dL; 95% CI, −20.81, 9.50; p=0.46), high-density lipoprotein (HDL-C) (WMD=0.16 mg/dL; 95% CI, −2.55, 2.88; p=0.91), and C-reactive protein (CRP) (WMD=−0.13 mg/L; 95% CI, −3.25, 3.30; p=0.93). Conclusions Our study showed that curcumin significantly impacts TC and TNF levels in CKD patients.

Bisacurone attenuates diabetic nephropathy by ameliorating oxidative stress, inflammation and apoptosis in rats

“…These findings imply that diabetes-related lipid changes induce kidney injury. 34 Bisacurone lowers TC and TG while increasing HDL-L. In this study, bisacurone's renal protective actions in DN rats are associated with a reduction in circulating lipids.…”

Is Curcumin Intake Really Effective for Chronic Inflammatory Metabolic Disease? A Review of Meta-Analyses of Randomized Controlled Trials

“…The effects of curcumin on lipid profiles in subjects with chronic kidney diseases were meta-analyzed by Futuhi et al 2022 [ 102 ]. Curcumin intake (80–500 mg/day of curcumin, 2500 mg/day of turmeric) for 8–12 weeks significantly reduced TC (WMD = −13.77 mg/dL; 95% CI −26.77 to −0.77; p = 0.04) in five publications [ 71 , 72 , 76 , 151 , 212 ] compared with the controls.…”

Pathogenesis and management of renal fibrosis induced by unilateral ureteral obstruction

“…Previous studies have reported that curcumin improves renal dysfunction through regulation of the immune system, suppression of inflammatory mediators, oxygen free radicals, and apoptosis, and preservation of mitochondrial integrity [76]. A systematic review and meta-analysis of clinical trials found that curcumin supplementation has potential as a treatment for CKD [77] and diabetic kidney disease [78]. These beneficial effects of curcumin have also been reported in animal models of ischemia-reperfusion injury [79], DN [80], and UUO [81].…”