The effects of curcumin‐containing supplements on biomarkers of inflammation and oxidative stress: A systematic review and meta‐analysis of randomized controlled trials

Tabrizi, Reza; Vakili, Sina; Akbari, Maryam; Mirhosseini, Naghmeh; Lankarani, Kamran Bagheri; Rahimi, Maryam; Mobini, Moein; Jafarnejad, Sadegh; Vahedpoor, Zahra; Asemi, Zatollah

doi:10.1002/ptr.6226

Cited by 125 publications

(79 citation statements)

References 36 publications

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“…Thus, while research using curcumin supplements with improved bioavailability (Meriva Curcumin [4,5]; Theracurcumin Theravalues [1,24,25,36]; Longvida [30]; CurcuWIN [10]; CurcuFresh [32] determined the dose at values between 150 and 1500 mg/day, studies using curcumin naturally [28,31] needed higher doses (5000 to 6000 mg/day) to achieve similar bioavailability.…”

Section: Curcumin Supplementationmentioning

confidence: 99%

Modulation of Exercise-Induced Muscle Damage, Inflammation, and Oxidative Markers by Curcumin Supplementation in a Physically Active Population: A Systematic Review

et al. 2020

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Physical activity, particularly high-intensity eccentric muscle contractions, produces exercise-induced muscle damage (EIMD). The breakdown of muscle fibers and the consequent inflammatory responses derived from EIMD affect exercise performance. Curcumin, a natural polyphenol extracted from turmeric, has been shown to have mainly antioxidant and also anti-inflammatory properties. This effect of curcumin could improve EIMD and exercise performance. The main objective of this systematic review was to critically evaluate the effectiveness of curcumin supplementation on EIMD and inflammatory and oxidative markers in a physically active population. A structured search was carried out following Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines in the databases SCOPUS, Web of Science (WOS), and Medline (PubMed) from inception to October 2019. The search included original articles with randomized controlled crossover or parallel design in which the intake of curcumin administered before and/or after exercise was compared with an identical placebo situation. No filters were applied to the type of physical exercise performed, the sex or the age of the participants. Of the 301 articles identified in the search, 11 met the established criteria and were included in this systematic review. The methodological quality of the studies was assessed using the McMaster Critical Review Form. The use of curcumin reduces the subjective perception of the intensity of muscle pain; reduces muscle damage through the decrease of creatine kinase (CK); increases muscle performance; has an anti-inflammatory effect by modulating the pro-inflammatory cytokines, such as TNF-α, IL-6, and IL-8; and may have a slight antioxidant effect. In summary, the administration of curcumin at a dose between 150–1500 mg/day before and during exercise, and up until 72 h’ post-exercise, improved performance by reducing EIMD and modulating the inflammation caused by physical activity. In addition, humans appear to be able to tolerate high doses of curcumin without significant side-effects.

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Section: Curcumin Supplementationmentioning

confidence: 99%

Modulation of Exercise-Induced Muscle Damage, Inflammation, and Oxidative Markers by Curcumin Supplementation in a Physically Active Population: A Systematic Review

et al. 2020

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“…Meta-analyses of randomised controlled trials, which assessed the effect of curcumin-containing supplements on oxidative stress and inflammation biomarkers, have suggested that curcumin-containing supplements exert antioxidant and anti-inflammatory effects through significant reductions in circulating serum concentrations of a panel of mediators such as malondialdehyde, interleukin 6 (IL-6) and TNF-α (207)(208)(209)(210). While interleukin-6 is a multi-functional cytokine that plays a key role in carcinogenesis of many human cancers, TNF-α is one of the major molecular mediators of a wide range of chronic inflammation and inflammation-related disorders (211).…”

Section: Curcumin and Piperinementioning

confidence: 99%

Chemoprevention of Prostate Cancer by Natural Agents: Evidence from Molecular and Epidemiological Studies

2019

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Background/Aim: Prostate cancer is one of the most common cancers in men which remains a global public health issue. Treatment of prostate cancer is becoming increasingly intensive and aggressive, with a corresponding increase in resistance, toxicity and side effects. This has revived an interest in nontoxic and cost-effective preventive strategies including dietary compounds due to the multiple effects they have been shown to have in various oncogenic signalling pathways, with relatively few significant adverse effects. Materials and Methods: To identify such dietary components and micronutrients and define their prostate cancer-specific actions, we systematically reviewed the current literature for the pertinent mechanisms of action and effects on the modulation of prostate carcinogenesis, along with relevant updates from epidemiological and clinical studies. Results: Evidence from various recent experimental, clinical and epidemiological studies indicates that select dietary micronutrients (i.e., lycopene, epigallocatechin gallate, sulforaphane, indole-3-carbinol, resveratrol, quercetin, curcumin & piperine) and zinc play a key role in prostate cancer prevention and progression and therefore hold great promise for the future overall management of prostate cancer. Conclusion: A formulation that comprises these micronutrients using the optimal, safest form and dosing should be investigated in future prostate cancer chemoprevention studies and as part of standard prostate cancer therapy.

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“…72 The antiinflammatory effects probably occurred through interference at different levels of the arachidonic acid inflammatory cascade and inhibition of proinflammatory compounds such as prostaglandins, leukotrienes, and COX-2. 68,69 Of note, a C. longa rhizome extract even protected collagen-induced arthritic Sprague-Dawley rats from the degenerative changes in the bone and ankle joints to a comparable extent as betamethasone. 74 Importantly, clinical trials with curcumin produced encouraging results in patients with rheumatoid arthritis 75 and postoperative inflammation.…”

Section: Curcuma Longa Lmentioning

confidence: 99%

“…Microbial infections, HIV infection, rheumatic disorders, gastrointestinal ailments, headache and body aches 7, 39,40,41 Phenylpropanoids such as 1'S'-1'acetoxychavicol acetate, terpenes/ terpenoids such as β-pinene, flavonoids such as galangin and alpinin 43,44 Antimicrobial, [46][47][48][49][50] Diarylheptanoids including curcuminoids such as curcumin, diarylpentanoids, sesquiterpenes, monoterpenes, diterpenes, and triterpenoids [65][66][67] Antinflammatory, [68][69][70][71][72][73][74][75][76][77][78][79][80][81][82][83] chemopreventive and anticancer, [85][86][87][88][89][90][91][92] antimicrobial, 62,93-95 Antiparasitic, 96 anti-Alzheimer activity [97][98][99] Hedychium coronarium J.…”

Section: Aframomum Melegueta K Schummentioning

confidence: 99%

“…66,67 The major volatile principles of the rhizome oil are α-and β-turmerone and aromatic -turmerone. 66,67 A host of pharmacological studies support the traditional use of C. longa preparations as well as curcumin against arthritic conditions (see, for instance, 68,69 ). Furthermore, administration of a rhizome extract, the rhizome volatile oil, curcumin itself, natural analogues of curcumin, or semi-synthetic curcumin analogues led to a decrease in carrageeninor formaline-induced rat paw edema as well as cotton pellet-induced granuloma in laboratory rats.…”

Section: Curcuma Longa Lmentioning

confidence: 99%

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Phytochemical and Pharmacological Support for the Traditional Uses of Zingiberacea Species in Suriname - A Review of the Literature

Mans¹,

Djotaroeno²,

Friperson³

et al. 2019

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the common ginger Zingiber officinale Roscoe are well-known spices, condiments, and flavoring compounds. 3 And the leaves and flowers from C. longa, the grains of paradise Aframomum melegueta K. Schum., the white ginger Hedychium coronarium J. Koenig, and the east-Indian galangal Kaempferia galanga L. are consumed as vegetables and used as key ingredients of spicy savory dishes and/or herbal teas. 3Various species in the genera Alpinia Roxb., 1810, Curcuma L., Globba L., Hedychium J. Koenig, Kaempferia L., and Renealmia L.f. have visually attractive flowers and inflorescences and are cultivated as ornamentals. 3 The rhizomes from many species in the genera Alpinia Roxb., 1810, Curcuma L., Hedychium J. Koenig, and Zingiber Mill., 1754 contain essential oils for producing soaps, cosmetics, and perfumes. 3 In addition, a number of ginger species are medicinally used in various traditional systems throughout the world. Examples are A. melegueta, C. longa, and Z. officinale, preparations of which are used for treating many diseases ranging from infectious diseases and inflammatory conditions to hypertension and diabetes mellitus. 4 Parts from A. melegueta, C. longa, and R. alpinia are also used in religious ceremonies. 3 This paper first presents some general information about the Zingiberacea family, subsequently provides some background on Suriname, then extensively addresses the traditional uses of one representative species of the seven Zingiberacea genera in the ABSTRACT The Zingiberacea or ginger family is a family of flowering plants comprising roughly 1,600 species of aromatic perennial herbs with creeping horizontal or tuberous rhizomes divided into about 50 genera. The Zingiberaceae are distributed throughout tropical Africa, Asia, and the Americas. Many members are economically important as spices, ornamentals, cosmetics, traditional medicines, and/or ingredients of religious rituals. One of the most prominent characteristics of this plant family is the presence of essential oils in particularly the rhizomes but in some cases also the leaves and other parts of the plant. The essential oils are in general made up of a variety of, among others, terpenoid and phenolic compounds with important biological activities. The Republic of Suriname (South America) is well-known for its ethnic and cultural diversity as well as its extensive ethnopharmacological knowledge and unique plant biodiversity. This paper first presents some general information on the Zingiberacea family, subsequently provides some background about Suriname and the Zingiberacea species in the country, then extensively addresses the traditional uses of one representative of the seven genera in the country and provides the phytochemical and pharmacological support for these uses, and concludes with a critical appraisal of the medicinal values of these plants.

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The effects of curcumin‐containing supplements on biomarkers of inflammation and oxidative stress: A systematic review and meta‐analysis of randomized controlled trials

Cited by 125 publications

References 36 publications

Modulation of Exercise-Induced Muscle Damage, Inflammation, and Oxidative Markers by Curcumin Supplementation in a Physically Active Population: A Systematic Review

Modulation of Exercise-Induced Muscle Damage, Inflammation, and Oxidative Markers by Curcumin Supplementation in a Physically Active Population: A Systematic Review

Chemoprevention of Prostate Cancer by Natural Agents: Evidence from Molecular and Epidemiological Studies

Phytochemical and Pharmacological Support for the Traditional Uses of Zingiberacea Species in Suriname - A Review of the Literature

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