The effects of curcumin on the invasiveness of prostate cancer in vitro and in vivo

Hong, Jung Hee; Ahn, Kwang Sung; Bae, Eun-Kyung; Jeon, Seong Soo; Choi, Han Yong

doi:10.1038/sj.pcan.4500856

Cited by 152 publications

(104 citation statements)

References 14 publications

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“…Additionally, they found that at increasing concentrations of curcumin (1, 5, 10 μg/ml), the invasive characteristics of cultured DU145 cells were blocked in a dose-dependent manner, with highest concentration inhibiting invasion by 71%. While, the 30-μM curcumin concentration used in our study was similar to the highest and most effective dose used in the study of Hong et al (10 μg/ml or ~27 μM), we observed the effect of curcumin in our study was far more subtle (19). We found that curcumin (30 μM; 18 h) blocked the invasive characteristics of PC-3 cells by 23% of control cells.…”

Section: Discussionsupporting

confidence: 27%

“…This finding is supported by other published reports. Hong et al for example, showed that curcumin decreased PCa tumor and metastasis burden of DU145 xenografts implanted into SCID mice, in part through the inhibition of MMP proteins after 24-h exposure (19). Additionally, they found that at increasing concentrations of curcumin (1, 5, 10 μg/ml), the invasive characteristics of cultured DU145 cells were blocked in a dose-dependent manner, with highest concentration inhibiting invasion by 71%.…”

Section: Discussionmentioning

confidence: 99%

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Curcumin blocks CCL2-induced adhesion, motility and invasion, in part, through down-regulation of CCL2 expression and proteolytic activity

Herman

Stadelman

Roselli³

2009

Int J Oncol

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Abstract. Expression and activity of CC motif ligand 2 (CCL2) is down-regulated by curcumin, the active phytochemical ingredient of turmeric (Curcuma longa), a dietary supplement often self-prescribed to promote prostate health. CCL2 is a potent chemotactic factor of prostate cancer (PCa) with important roles in development of bone metastasis. The relationship between CCL2 and curcumin, however, has not been studied in PCa. Adhesion, invasion and motility of PC-3 cells were measured in response to exposure to curcumin (30 μM; 18 h), CCL2 (100 ng/ml; 18 h) or PMA (100 ng/ml; 18 h). CCL2 mRNA expression and protein secretion levels were measured by real-time PCR and ELISA respectively. Curcumin significantly blocked CCL2 induced adhesion, invasion and motility. Curcumin also significantly suppressed the mRNA expression and secreted CCL2 protein levels. The addition of PMA, a protein kinase C (PKC) activator, blocked the effects of curcumin, leading to an increase in CCL2 expression as well as an increase in PC-3 cell adhesion, invasion and motility. The introduction of a PKC inhibitor, however, blocked the effects of CCL2. We also found that curcumin, CCL2 and PMA, in part, function through the differential regulation of the proteolytic protein matrix metalloproteinase (MMP)-9. These data indicate a potential mechanism; by which curcumin can block the chemotactic effects of CCL2 on PCa. Curcumin exerts potential anti-metastatic effects in bone-derived PCa cells by blocking CCL2 mediated actions on invasion, adhesion and motility, in part through differential regulation of PKC and MMP-9 signaling.

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Section: Discussionsupporting

confidence: 27%

Section: Discussionmentioning

confidence: 99%

Curcumin blocks CCL2-induced adhesion, motility and invasion, in part, through down-regulation of CCL2 expression and proteolytic activity

Herman

Stadelman

Roselli³

2009

Int J Oncol

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“…In addition, curcumin has been observed to induce a marked reduction in MMP-2 and MMP-9 activity in tumor-bearing sites. A previous study demonstrated significantly fewer metastatic nodules in a curcumin-treated group compared with the untreated group (75).…”

Section: Prostate Cancermentioning

confidence: 99%

Biological and therapeutic activities, and anticancer properties of curcumin

Perrone

Ardito

Giannatempo

et al. 2015

Experimental and Therapeutic Medicine

266

186

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Abstract. Curcumin (diferuloylmethane) is a polyphenol derived from the Curcuma longa plant. Curcumin has been used extensively in Ayurvedic medicine, as it is nontoxic and exhibits a variety of therapeutic properties, including antioxidant, analgesic, anti-inflammatory and antiseptic activities. Recently, certain studies have indicated that curcumin may exert anticancer effects in a variety of biological pathways involved in mutagenesis, apoptosis, tumorigenesis, cell cycle regulation and metastasis. The present study reviewed previous studies in the literature, which support the therapeutic activity of curcumin in cancer. In addition, the present study elucidated a number of the challenges concerning the use of curcumin as an adjuvant chemotherapeutic agent. All the studies reviewed herein suggest that curcumin is able to exert anti-inflammatory, antiplatelet, antioxidative, hepatoprotective and antitumor activities, particularly against cancers of the liver, skin, pancreas, prostate, ovary, lung and head neck, as well as having a positive effect in the treatment of arthritis.

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“…Accordingly, several studies demonstrated a correlation between high invasiveness and decreased TIMP-1- (Khokha et al, 1989;Chan et al, 2005) or increased MMP-2 expression (Mori et al, 2004;Choi et al, 2005). Conversely, the antiinvasive action of several anticarcinogenic substances has been associated with elevated TIMP-1 (Khokha et al, 1992;Park et al, 2005) or diminished MMP-2 levels (Park et al, 2005;Hong et al, 2006).…”

mentioning

confidence: 99%

Upregulation of tissue inhibitor of matrix metalloproteinases-1 confers the anti-invasive action of cisplatin on human cancer cells

2007

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Cancer cell invasion is one of the crucial events in local spreading, growth and metastasis of tumors. The present study investigates the mechanism underlying the antiinvasive action of the chemotherapeutic cisplatin. In human cervical carcinoma cells (HeLa), cisplatin caused a time-and concentration-dependent suppression of cell invasion through Matrigel. Inhibition of invasion was accompanied by upregulation of tissue inhibitor of matrix metalloproteinases-1 (TIMP-1), whereas levels of matrix metalloproteinase-2 (MMP-2), MMP-9 and TIMP-2 remained unchanged. Cisplatin's effects on TIMP-1 expression and invasion were associated with phosphorylations of p38 and p42/44 mitogen-activated protein kinases and were abrogated by specific inhibitors of both pathways. The impact of TIMP-1 in the anti-invasive action of cisplatin was proven by transfecting cells with small interfering RNA targeting TIMP-1, which completely reversed suppression of invasion by cisplatin. A functional relevance of TIMP-1 upregulation was substantiated by findings showing a concentration-dependent inhibition of Matrigel invasion by recombinant TIMP-1. The essential role of TIMP-1 in the anti-invasive action of cisplatin was confirmed using another human cervical carcinoma cell line (C33A) and human lung carcinoma cells (A549). Altogether, our data demonstrate a hitherto unknown mechanism by which cisplatin exerts its antimetastatic properties on highly invasive cancer cells.

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The effects of curcumin on the invasiveness of prostate cancer in vitro and in vivo

Cited by 152 publications

References 14 publications

Curcumin blocks CCL2-induced adhesion, motility and invasion, in part, through down-regulation of CCL2 expression and proteolytic activity

Curcumin blocks CCL2-induced adhesion, motility and invasion, in part, through down-regulation of CCL2 expression and proteolytic activity

Biological and therapeutic activities, and anticancer properties of curcumin

Upregulation of tissue inhibitor of matrix metalloproteinases-1 confers the anti-invasive action of cisplatin on human cancer cells

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