The Effects of Curcumin on Weight Loss Among Patients With Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Abstract

Background and objective: The current systematic review and meta-analysis of randomized controlled trials (RCTs) was carried out to assess the influence of curcumin intake on weight among patients with metabolic syndrome and related disorders. Methods: We searched the following databases up until January 2018: MEDLINE, EMBASE, Web of Science, and Cochrane Central Register of Controlled Trials. The relevant data were extracted and evaluated for quality of the studies in accordance with the Cochrane risk of bias tool. Data were pooled using the inverse variance method and expressed as standardized mean difference (SMD) with 95% confidence intervals (95% CI). Results: Eighteen articles (21 studies) that comprised a total of 1,604 individuals were finally included in the meta-analysis. Curcumin intake significantly reduced body mass index (BMI) (SMD −0.37; 95% CI, −0.61, −0.13; P < 0.01), weight (SMD −0.23; 95% CI, −0.39, −0.06; P < 0.01), waist-circumference (WC) (SMD −0.25; 95% CI, −0.44, −0.05; P = 0.01), leptin levels (SMD −0.97; 95% CI, −1.18, −0.75; P < 0.001) and increased adiponectin levels (SMD 1.05; 95% CI, 0.23, 1.87; P = 0.01). We found no significant effect of curcumin intake on hip ratio (HR) (SMD −0.17; 95% CI, −0.42, 0.08; P = 0.18). Conclusions: Overall, we have found that curcumin intake among patients with metabolic syndrome and related disorders was correlated with a significant reduction in BMI, weight, WC, and leptin, and a significant increase in adiponectin levels, but did not affect HR.

Curcumin: Could This Compound Be Useful in Pregnancy and Pregnancy-Related Complications?

“…In obese women with polycystic ovary syndrome (PCOS), 1000 mg/day curcumin supplementation (500 mg twice daily: 70–80% curcumin, 15–20% demethoxycurcumin and 2.5–6.5% bisdemethoxycurcumin) for six weeks improved serum insulin and the Quantitative Insulin Sensitivity Check Index [ 45 ]. A recent meta-analysis reported that curcumin intake was associated with reduced body mass index (BMI), body weight, body fat, leptin value, and increased adiponectin levels in patients with metabolic syndrome and related disorders [ 46 ]. Overall, the dosage and duration of curcumin supplementation appear to differently modulate glucose metabolism in humans.…”

Current Evidence to Propose Different Food Supplements for Weight Loss: A Comprehensive Review

“…In addition, a significant reduction of BMI and liver fat was also observed by Rahmani et al after the administration of 70 mg/day curcumin for eight weeks among people with NAFLD [179]. Another more recent line of evidence is represented by a systematic review and metanalysis of 21 RCTs which indicated that curcumin intake significantly reduced BMI, weight, and waist-circumference [180]. However, not all reports point in the same promising direction.…”

Effects of Curcumin in a Mouse Model of Very High Fat Diet-Induced Obesity

“…The anti-obesity effects of curcumin and curcuminoids are being investigated extensively in clinical and animal model-based studies [ 12 , 34 , 35 ]. In clinical obesity studies, curcumin intake improved a set of pivotal body composition parameters, including reducing body weight, body mass index (BMI), and waist circumference and modulating the adiponectin and leptin levels [ 34 ].…”

“…The anti-obesity effects of curcumin and curcuminoids are being investigated extensively in clinical and animal model-based studies [ 12 , 34 , 35 ]. In clinical obesity studies, curcumin intake improved a set of pivotal body composition parameters, including reducing body weight, body mass index (BMI), and waist circumference and modulating the adiponectin and leptin levels [ 34 ]. Based on the body surface area normalization method of animal-to-human drug dose conversion [ 36 ], and daily food consumption rate for mice observed in our previous studies, 0.7% w / w curcumin corresponds to 5 g/day curcumin consumption by a 75-kg adult human.…”