The effects of curcumin supplementation on liver function, metabolic profile and body composition in patients with non-alcoholic fatty liver disease: A systematic review and meta-analysis of randomized controlled trials

Jalali, Mohammad; Mahmoodi, Marzieh; Mosallanezhad, Zahra; Jalali, Ronak; Imanieh, Mohammad Hadi; Moosavian, Seyedeh Parisa

doi:10.1016/j.ctim.2019.102283

Cited by 68 publications

(65 citation statements)

References 33 publications

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“…Based on the findings of the present work, curcumin supplementation significantly improved FPG, plasma insulin levels, HOMA‐IR, QUICKI, and some lipid profiles including total‐ and LDL‐cholesterol; however, triglycerides, HDL‐, and VLDL‐cholesterol levels remained unchanged. In line with our findings, a recent meta‐analysis by Jalali et al (2020) stated that curcumin supplementation in patients with NAFLD decreased FPG, insulin levels, HOMA‐IR, total‐, and LDL‐cholesterol values. Another meta‐analysis of curcumin supplementation indicated a significant decrease of FPG, insulin resistance, and total cholesterol in patients with MetS (Fraser & Price, 1990).…”

Section: Discussionsupporting

confidence: 93%

“…In addition, there is evidence supporting the beneficial metabolic effects of curcumin supplementation. Previously, a meta‐analysis revealed that supplementation with this nutraceutical improved the parameters of insulin metabolism and some lipid fractures in patients with nonalcoholic fatty liver disease (NAFLD) (Jalali et al, 2020). Another meta‐analysis illustrated that taking curcumin containing supplements led to a significant decrease in the levels of some inflammatory indicators and oxidative stress biomarkers in individuals with metabolic syndrome (MetS) (Tabrizi et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

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The effects of curcumin intake on wound healing and metabolic status in patients with diabetic foot ulcer: A randomized, double‐blind, placebo‐controlled trial

Mokhtari

Razzaghi

Momen‐Heravi

2020

Phytotherapy Research

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This study was conducted to determine the effects of curcumin intake on wound healing and metabolic status in patients with diabetic foot ulcer (DFU). The current randomized, double‐blind, placebo‐controlled trial was conducted among 60 patients with grade 3 DFU. Participants were randomly allocated into two groups (30 participants each group), received either 80 mg nanocurcumin daily for 12 weeks or placebo. Primary endpoints in this study were serum insulin levels and insulin resistance. Curcumin intake significantly decreased fasting plasma glucose (p = .02), insulin (p = .01), insulin resistance (p = .02), and significantly increased insulin sensitivity (p = .008) compared with the placebo. Moreover, curcumin intake led to a significant reduction in total‐ (p < .001), LDL‐cholesterol (p < .001), and a significant increase in total antioxidant capacity (TAC) (p < .001) and total glutathione (GSH) (p = .01) compared with the placebo. However, there was no significant improvement in wound healing parameters. Overall, our study demonstrated that nanocurcumin intake in patients with DFU resulted in a significant improvement of glycemic control, total‐ and LDL‐cholesterol, TAC, and GSH but did not affect the indicators of ulcer size.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

The effects of curcumin intake on wound healing and metabolic status in patients with diabetic foot ulcer: A randomized, double‐blind, placebo‐controlled trial

Mokhtari

Razzaghi

Momen‐Heravi

2020

Phytotherapy Research

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“…Despite the poor bioavailability of curcumin, a few recent meta-analyses described that curcumin/turmeric alleviated hepatic steatosis [ 201 ] and positivelyinfluencedliver-related outcomes, like ALT and AST (especially in doses higher than 1000 mg/day) [ 202 , 203 ]. Jalali et al [ 204 ], in ameta-analysis (n-9 RCTs), aimed to investigate the effects of curcumin on NAFLD and concluded that curcumin-based interventions resulted in ALT, AST, TC, LDL, FBS, HOMA-IR, and serum insulin reduction, but had no effects on the TG, HDL, HbA1c, body weight, and BMI.…”

Section: New Dietary Perspectives In Nafld Treatment Via Gm Modulamentioning

confidence: 99%

Nutritional Approach Targeting Gut Microbiota in NAFLD—To Date

Moszak

Szulińska

Walczak-Gałęzewska

et al. 2021

IJERPH

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Non-alcoholic fatty liver disease (NAFLD) is a significant clinical and epidemiological problem that affects around 25% of the adult global population. A large body of clinical evidence highlights that NAFLD is associated with increased liver-related morbidity and mortality and an increased risk of cardiovascular disease, extrahepatic cancers, type 2 diabetes, and chronic kidney disease. Recently, a series of studies revealed the pivotal role of gut microbiota (GM) dysbiosis in NAFLD’s pathogenesis. The GM plays an essential role in different metabolic pathways, including the fermentation of diet polysaccharides, energy harvest, choline regulation, and bile acid metabolism. One of the most critical factors in GM stabilization is the diet; therefore, nutritional therapyappearsto be a promising tool in NAFLD therapy. This paper aims to review the current knowledge regardingthe nutritional approach and its implications with GM and NAFLD treatment. We discuss the positive impact of probiotics, prebiotics, and symbiotics in a reverse dysbiosis state in NAFLD and show the potential beneficial effects of bioactive substances from the diet. The full description of the mechanism of action and comprehensive examination of the impact of nutritional interventions on GM modulation may, in the future, be a simple but essential tool supporting NAFLD therapy.

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“…In recent years, several natural products showed strong nephroprotective activity [ 10 , 11 , 12 , 13 ]. Curcumin (CUR), the Curcuma longa Linn yellow pigment, has attracted much attention for medicinal purposes in a wide range of illnesses such as autoimmune diseases [ 14 ], cancer [ 15 ], diabetes mellitus [ 16 ], and fatty liver disease [ 17 , 18 ]. CUR has a potent antioxidant [ 19 , 20 ], anti-inflammatory [ 14 ], antiproliferative [ 21 , 22 ], immunostimulant [ 23 ], and neuroprotective activities [ 4 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of Curcumin against Sodium Salicylate-Induced Oxidative Kidney Damage, Nuclear Factor-Kappa Dysregulation, and Apoptotic Consequences in Rats

et al. 2021

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This study examined the effect of sodium salicylates (SS), alone and in combination with curcumin (CUR), on kidney function and architecture in rats. Five rat groups were given 1 mL physiological saline/rat orally, 1 mL olive oil/rat orally, 50 mg CUR/kg bwt orally, 300 mg SS/kg bwt intraperitoneally, or CUR+SS for 15 days. The hematological indices, serum protein profile, serum electrolytes balance, oxidative stress, and lipid peroxidation of kidney tissues were assessed. The histopathological examination and immune expression of Caspase-3 and nuclear factor kappa (NF-κB) were conducted. The findings showed that SS injection induced nephrotoxic activity, including increased serum urea, creatinine, and uric acid levels. It also caused apparent pathological alterations with increased Caspase-3 and NF-κB immuno-expression. In addition, thrombocytopenia, leukocytosis, neutrophilia, hyponatremia, hypochloremia, hypocalcemia, and hypomagnesemia but not hyperkalemia and hyperphosphatemia were evident in SS-injected rats. Moreover, SS exposure increased serum α1 globulin, renal tissue malondialdehyde, and Caspase-3 levels but superoxide dismutase, glutathione peroxidase, and Bcl-2 levels declined. Meanwhile, CUR significantly counteracted the SS harmful impacts on kidneys but SS+CUR co-administration induced an anemic condition. Overall, CUR has an evident protective role against SS-induced renal damage, but the disturbed hematological alterations should be carefully taken into consideration in their combined use.

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The effects of curcumin supplementation on liver function, metabolic profile and body composition in patients with non-alcoholic fatty liver disease: A systematic review and meta-analysis of randomized controlled trials

Cited by 68 publications

References 33 publications

The effects of curcumin intake on wound healing and metabolic status in patients with diabetic foot ulcer: A randomized, double‐blind, placebo‐controlled trial

The effects of curcumin intake on wound healing and metabolic status in patients with diabetic foot ulcer: A randomized, double‐blind, placebo‐controlled trial

Nutritional Approach Targeting Gut Microbiota in NAFLD—To Date

Protective Effect of Curcumin against Sodium Salicylate-Induced Oxidative Kidney Damage, Nuclear Factor-Kappa Dysregulation, and Apoptotic Consequences in Rats

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