The effects of cystoscopy and hydrodistention on symptoms and bladder capacity in interstitial cystitis/bladder pain syndrome

Kirk, Peter S.; Santiago‐Lastra, Yahir; Qin, Yongmei; Stoffel, John T.; Clemens, J. Quentin; Cameron, Anne P.

doi:10.1002/nau.23555

Cited by 17 publications

(8 citation statements)

References 23 publications

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“…This discussion of flare triggers and related symptoms supports previous work that guides the contemporary evaluation and treatment of men with UCPPS 13,19–25 . Participants in the MAPP focus groups described a wide range of symptom exacerbations, with a significant degree of distress expressed over urinary symptoms in addition to their pain.…”

Section: Discussionsupporting

confidence: 72%

Flares and their impact among male urologic chronic pelvic pain syndrome patients: An in‐depth qualitative analysis in the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network

Quallich

Clemens

Ronstrom

et al. 2022

Neurourology and Urodynamics

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Introduction There has been a sparse exploration of the lived experience of men with urologic chronic pelvic pain syndrome (UCPPS), and none with the goal of Investigating the experience of “flares” as part of this chronic pain syndrome in men. Methods We conducted three focus groups of male UCPPS patients at two sites of the MAPP Research Network (n = 16 total participants) to explore the full spectrum of flares and their impact on men's lives. Results Flare experiences were common and specific symptom components varied widely. Men reported nonpelvic symptoms (e.g., diarrhea), and variability in symptom intensity (mild to severe), duration (minutes to days), and frequency of flares. Flares episodes, and the threat of flares, were disruptive to their lives, social roles, and relationships. Distinct long‐term impacts were reported, such as decreased sexual activity, decreased travel, and potential loss of employment or career. The themes included social isolation and the need for a sense of control and understanding over their unpredictable symptoms. Conclusions Given their negative impact, future research with men and UCPPS should focus on approaches to prevent flares, and should consider a multimodal approach to reducing the frequency, severity, and/or duration. Quality of life may be improved by providing men with a sense of control over their symptoms and offering them multimodal treatment options, consistent with the recommendations for further research for women with UCPPS.

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Section: Discussionsupporting

confidence: 72%

Flares and their impact among male urologic chronic pelvic pain syndrome patients: An in‐depth qualitative analysis in the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network

Quallich

Clemens

Ronstrom

et al. 2022

Neurourology and Urodynamics

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“…Multiple studies found worsening symptoms or no statistically significant changes following HD 20,22,23 . This is supported by a study with a large sample size (328 patients), which found no statistically significant changes in pain scores 39 . The concordance between multiple studies concerning the inefficacy of HD suggests this approach may not yield long‐term symptomatic relief in patients with IC/BPS.…”

Section: Discussionmentioning

confidence: 80%

“…The study by Kirk et al 39 had a large sample size of patients suffering from BPS (328 patients) and found a decrease in symptom scores of only 14% and no statistically significant changes in pain. Furthermore, other studies also found symptoms were worsened or observed no statistically significant changes in symptoms following hydrodistension (HD) 20,22,23 .…”

Section: Resultsmentioning

confidence: 99%

“…20,22,23 This is supported by a study with a large sample size (328 patients), which found no statistically significant changes in pain scores. 39 The concordance between multiple studies concerning the inefficacy of HD suggests this approach may not yield long-term symptomatic relief in patients with IC/BPS. Resection of ilioinguinal and iliohypogastric nerves is only applicable to a very select group of patients and hence is unlikely to be beneficial to the majority of patients with IC/BPS.…”

Section: Discussionmentioning

confidence: 98%

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Comparing surgical interventions for interstitial cystitis: A systematic review

Lastoria

Raison

Aydın

et al. 2022

LUTS

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The purpose of this review was to summarize and compare the efficacy among surgical interventions in terms of symptomatic relief in patients with interstitial cystitis/ bladder pain syndrome (IC/BPS). The review protocol was published on PROSPERO.The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 checklist was followed. Following database search, a narrative synthesis was performed. Data pertaining symptom scores, pain levels, and voiding frequency following surgery were summarized by calculating percentage change in these parameters. Multiple surgical treatments were identified. These included injections of hyaluronic acid (HA), botulinum toxin A (Botox A), triamcinolone, resiniferatoxin (RTX), platelet-rich plasma, and 50% dimethyl sulfoxide (DMSO) solution, neuromodulation, hydrodistension (HD), resection/fulguration of Hunner lesions, resection of ilioinguinal and iliohypogastric nerves, reconstructive surgery, and cystectomy. This review found no evidence suggesting that HD and RTX injections can ameliorate IC/BPS symptoms.Current evidence suggests that sacral neuromodulation, cystectomy, and transurethral resection/fulguration of Hunner lesions could lead to symptomatic relief in IC/BPS. Further research into the efficacy of Botox A, triamcinolone, 50% DMSO solution, and HA instillations is required. However, the best treatment options cannot be reliably stated due to the low level of evidence of the studies identified. Further research should report outcomes for Hunner-type IC and BPS separately given their differing histopathological characteristics. Performing high-quality randomized controlled trials could be hindered by the low prevalence of the condition and a small proportion of patients progressing to surgery.

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“…Among lower urinary tract symptoms, patients commonly misinterpret urinary urgency as pain or fear of urinating unintentionally, but this is also not a requirement for diagnosis. Again, current bladder-related pain and discomfort are the primary and essential diagnostic requirements [16][17][18][19][20][21][22][23][24][25].…”

Section: Considering Points For the Diagnosis Of Interstitial Cystiti...mentioning

confidence: 99%

Clinical Approach to Recurrent Voiding Dysfunction, Dysuria, and Pelvic Pain Persisting for at Least 3 Months

Kim

2022

Int Neurourol J

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There are several patients with urination problems and urethral and pelvic discomfort. Usually, these patients’ symptoms are persistent and ambiguous; therefore, it is difficult to find underlying diseases associated with the patient’s symptoms. In addition, there are various conditions such as overactive bladder, cystitis, and interstitial cystitis/bladder pain syndrome (IC/BPS). Sometimes patients with other chronic disorders such as fibromyalgia, inflammatory bowel syndrome, and vulvodynia show urination problems and pelvic pain. Thus, a patient-centered approach is important to find the cause of chronic urination problems and pelvic pain. Moreover, IC/BPS should be considered during the diagnostic process because the clinical characteristics of IC/BPS are diverse. In this narrative review, we suggest an integral approach for the diagnosis and treatment of IC/ BPS.

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The effects of cystoscopy and hydrodistention on symptoms and bladder capacity in interstitial cystitis/bladder pain syndrome

Abstract: Hydrodistention does not decrease bladder capacity even with multiple procedures, and measurably improves symptoms in some patients with IC/BPS. Continuing efforts to better identify those patients most likely to benefit from this procedure are justified.

Cited by 17 publications

References 23 publications

Flares and their impact among male urologic chronic pelvic pain syndrome patients: An in‐depth qualitative analysis in the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network

Flares and their impact among male urologic chronic pelvic pain syndrome patients: An in‐depth qualitative analysis in the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network

Comparing surgical interventions for interstitial cystitis: A systematic review

Clinical Approach to Recurrent Voiding Dysfunction, Dysuria, and Pelvic Pain Persisting for at Least 3 Months

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