The Effects of Cytoplasmic Transfer of mtDNA in Relation to Whole-Body Endurance Performance.

Soma, Rika; Murakami, Haruka; Hayashi, Jun‐Ichi; Ito, Sayaka; Nagai, Jun; Sugita, Masaaki; Kuno, Shinya; Okada, Morihiko

doi:10.2170/jjphysiol.51.475

Cited by 5 publications

(1 citation statement)

References 32 publications

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“…We also studied about the relationship between mtDNA polymorphism and individual differences in endurance capacity or trainability. In a previous study, we focused on the coding region of mtDNA and examined the relation between endurance performance and mitochondrial capacity, which reflected the polymorphism in this region, excluding the influence of the individual nuclear DNA [23,24]. However, we have not confirmed any link between individual differences in endurance capacity or trainability and the polymorphism in the mtDNA coding region.…”

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confidence: 59%

Polymorphisms in Control Region of mtDNA Relates to Individual Differences in Endurance Capacity or Trainability.

Murakami

Ota²,

Simojo³

et al. 2002

JJP

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contrasting

confidence: 59%

Polymorphisms in Control Region of mtDNA Relates to Individual Differences in Endurance Capacity or Trainability.

Murakami

Ota²,

Simojo³

et al. 2002

JJP

Self Cite

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Mitochondrial DNA Sequence Variation and Performance

Kuno

Zempo

Murakami

2010

Genetic and Molecular Aspects of Sport Performance

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Aberrant heteroplasmic transmission of mtDNA in cloned pigs arising from double nuclear transfer

2005

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Double nuclear transfer begins with the transfer of nuclear DNA from a donor cell into an enucleated recipient oocyte. This reconstructed oocyte is allowed to develop to the pronuclear stage, where the pronuclei are transferred into an enucleated zygote. This reconstructed zygote is then transferred to a surrogate sow. The genetic integrity of cloned offspring can be compromised by the transmission of mitochondrial DNA from the donor cell, the recipient oocyte and the recipient zygote. We have verified through the use of sequence analysis, restriction fragment length polymorphism analysis, allele specific PCR and primer extension polymorphism analysis that following double nuclear transfer the donor cell mtDNA is eliminated. However, it is likely that the recipient oocyte and zygote mitochondrial DNA are transmitted to the offspring, indicating bimaternal mitochondrial DNA transmission. This pattern of mtDNA inheritance is similar to that observed following cytoplasmic transfer and violates the strict unimaternal inheritance of mitochondrial DNA to offspring. This form of transmission raises concerns regarding the genetic integrity of cloned offspring and their uses in studies that require metabolic analysis or a stable genetic environment where only one variable is under analysis, such as in knockout technology.

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The Effects of Cytoplasmic Transfer of mtDNA in Relation to Whole-Body Endurance Performance.

Cited by 5 publications

References 32 publications

Polymorphisms in Control Region of mtDNA Relates to Individual Differences in Endurance Capacity or Trainability.

Polymorphisms in Control Region of mtDNA Relates to Individual Differences in Endurance Capacity or Trainability.

Mitochondrial DNA Sequence Variation and Performance

Aberrant heteroplasmic transmission of mtDNA in cloned pigs arising from double nuclear transfer

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