The Effects of d-Tubocurarine on Spontaneous Postganglionic Sympathetic Activity and Histamine Release

McCullough, Lynne S.; Reier, Charles E.; Delaunois, A. L.; Gardier, Robert W.; Hamelberg, William

doi:10.1097/00000542-197009000-00012

Cited by 17 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These changes with d-tubocurarine are identical with a previous study reported by our laboratory showing the effect of a muscle paralyzing dose (0.4 mg/kg) and a 2.5 times the muscle paralyzing dose (1 .O mglkg) of d-tubocurarine on heart rate, MAP, SPGSA and histamine(4). 1B) coincident with an approximate threefold increase in blood histamine (Fig.…”

supporting

confidence: 91%

“…dose proportional to the higher dose of pancuronium produced an initial slight increase in heart rate followed by a significant decrease (P < 0.05) at 5 min post injection in confirmation of previous studies (Fig. dose of d-tubocurarine, ganglionic blockade to electrical stimulation as well as a marked elevation in blood histamine could be demonstrated (4). Moreover, d-tubocurarine effected a significant (P < 0.001) fall in mean arterial blood pressure Discussion.…”

supporting

confidence: 89%

“…It has been demonstrated in cats that hypotension from d-tubocararine is associated with a decrease in spontaneous postganglionic sympathetic activity in low doses and with the added dimension of histamine release at higher doses (4). Any drug chosen to clinically replace d-tubocurarine, must be devoid of its untoward effects.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Comparative Effects of Pancuronium and d -Tubocurarine on Blood Histamine and Sympathetic Activity

DeLeo

Langley

Delaunois

et al. 1974

Experimental Biology and Medicine

View full text Add to dashboard Cite

Pancuronium bromide (Pavulon) is a new long-acting, nondepolarizing type muscle relaxant (1-3). Any drug chosen to clinically replace d-tubocurarine, must be devoid of its untoward effects. Hypotension is one of these. It has been demonstrated in cats that hypotension from d-tubocararine is associated with a decrease in spontaneous postganglionic sympathetic activity in low doses and with the added dimension of histamine release at higher doses (4). The present study was conducted to comparatively evaluate pancuronium and d-tubocurarine on those same functions that are responsible for the hypotensive action of the latter agent.Methods and Materials. Unpremedicated cats (2.1-3.2 kg) were lightly anesthetized with 20 mg/kg iv pentobarbital sodium (Nembutal) and maintained at this level with intermittent doses of 2.5-5 mg/kg as necessary. Mean arterial pressure (MAP) and heart rate were recorded from a catheter in the femoral artery. Drug injections and fluid replacement (Lactated Ringers solution, I0 ml/kg/hr) were made through a femoral venous catheter. Blood histamine was determined according to a modified method of Anton and Sayre (4, 5) on samples obtained from the right atrium via a jugular venous catheter. The trachea was cannulated and pulmonary ventilation was controlled by a Palmer pump with room air adequate to maintain arterial blood gases at Pao2 98 -+ 10 Tom and Paco2 36 ? 4 Tom. Rectal temperature was maintained at 37 ? 0.5" with a warming-cooling blanket.The tibialis anterior muscle tendon was divided and attached to a FT03B force displacement transducer under 20 g tension while the sciatic nerve was sectioned and the common peroneal nerve placed on a bipolar electrode.Stimulations were at supramaximal voltage, 0.1 msec duration and 0.2 Hz from a Grass S4 stimulator and recordings made with a Grass 5B polygraph.A postganglionic nerve from the celiac ganglion, exposed by a left flank retroperitoneal approach, was isolated and placed on a bipolar platinum electrode. Action potentials were displayed on a Tektronix 565 oscilloscope photographed with a Grass Kymographic camera at a film speed of 5 mm/sec. For quantitation the spontaneous postganglionic sympathetic activity (SPGSA) was simultaneously transmitted to a Grass 5P3 EMG integrator preamplifier with a 0.2 sec time constant and recorded on a Grass 5B polygraph at 5 m d s e c . The area under the integrated activity for 10 sec was measured with a planimeter. Injections of 0.75 mg/kg trimethaphan (Arfonad) at the conclusion of the experiment were used to prove the postganglionic nature of the activity.Results. The dose-response curve constructed for pancuronium bromide indicated that the minimum fully effective dose was between 0.02 and 0.04 mg/kg. Therefore, each of the seven cats used herein were given an initial dose of 0.04 mg/kg of pancuronium, which produced complete paralysis in all cats. Two and one-half times this dose (0.1 mg/kg) of pancuronium then was chosen for comparison with 1 mg/kg of d-tubocurarine chloride, determined in an identic...

show abstract

supporting

confidence: 91%

supporting

confidence: 89%

See 1 more Smart Citation

Comparative Effects of Pancuronium and d -Tubocurarine on Blood Histamine and Sympathetic Activity

DeLeo

Langley

Delaunois

et al. 1974

Experimental Biology and Medicine

View full text Add to dashboard Cite

show abstract

“…6 Different from the classic nondepolarizing muscle relaxant d-tubocurare, early studies showed that rocuronium only caused minimal cardiovascular side effects at clinically relevant concentrations, such as a decrease in mean arterial pressure, systemic vascular resistance, and an increase in heart rate, 7 which are supposedly caused by its vagolytic effects. 13 In contrast to these actions, clinically relevant concentrations of rocuronium cause negligible histamine release and vagolytic effects 14 ; however, its side effects might originate from an interaction with neuronal nAChRs. 10,11 Structurally similar to the well-characterized muscle nAChRs, neuronal nAChRs mediate fast synaptic transmission in sympathetic, parasympathetic, and enteric autonomic ganglia and regulate the function of the cardiovascular system.…”

Section: Introductionmentioning

confidence: 99%

Competitive Inhibition of the Nondepolarizing Muscle Relaxant Rocuronium on Nicotinic Acetylcholine Receptor Channels in the Rat Superior Cervical Ganglia

Zhang

Wang

Zhang

et al. 2014

Journal of Cardiovascular Pharmacology

View full text Add to dashboard Cite

A number of case reports now indicate that rocuronium can induce a number of serious side effects. We hypothesized that these side effects might be mediated by the inhibition of nicotinic acetylcholine receptors (nAChRs) at superior cervical ganglion (SCG) neurons. Conventional patch clamp recordings were used to study the effects of rocuronium on nAChR currents from enzymatically dissociated rat SCG neurons. We found that ACh induced a peak transient inward current in rat SCG neurons. Additionally, rocuronium suppressed the peak ACh-evoked currents in rat SCG neurons in a concentration-dependent and competitive manner, and it increased the extent of desensitization of nAChRs. The inhibitory rate of rocuronium on nAChR currents did not change significantly at membrane potentials between -70 and -20 mV, suggesting that this inhibition was voltage independent. Lastly, rocuronium preapplication enhanced its inhibitory effect, indicating that this drug might prefer to act on the closed state of nAChR channels. In conclusion, rocuronium, at clinically relevant concentrations, directly inhibits nAChRs at the SCG by interacting with both opened and closed states. This inhibition is competitive, dose dependent, and voltage independent. Blockade of synaptic transmission in the sympathetic ganglia by rocuronium might have potentially inhibitory effects on the cardiovascular system.

show abstract

Kreislaufbeeinflussung durch nicht depolarisierende Relaxantien

Schaer¹

1974

Anaesthesie Atmung — Kreislauf

View full text Add to dashboard Cite

The Effects of d-Tubocurarine on Spontaneous Postganglionic Sympathetic Activity and Histamine Release

Cited by 17 publications

References 0 publications

Comparative Effects of Pancuronium and d -Tubocurarine on Blood Histamine and Sympathetic Activity

Comparative Effects of Pancuronium and d -Tubocurarine on Blood Histamine and Sympathetic Activity

Competitive Inhibition of the Nondepolarizing Muscle Relaxant Rocuronium on Nicotinic Acetylcholine Receptor Channels in the Rat Superior Cervical Ganglia

Kreislaufbeeinflussung durch nicht depolarisierende Relaxantien

Contact Info

Product

Resources

About