The Effects of Daily Irradiation with Polychromatic Visible Polarized Light on Human Lymphocyte Populations

Abstract

The application of polychromatic visible polarized light with the aforementioned features increases the CD3(+)CD4(+) lymphocyte population. It is suggested that this regimen may be useful for the promotion of natural defenses in cell-mediated immunity.

Irradiation with Polychromatic Incoherent Low Energy Radiation of Human Peripheral Blood Mononuclear Cells In Vitro: Effects on Cytokine Production

“…In this way, the inflammatory processes can be limited, and the reparative phase triggers. Our results may, in part, explain the healing of the wounded area and the improvement in chronic inflammatory processes, previously observed by us [12] and other researches [8][9][10][11][17][18][19][20][21][22] in vivo.…”

“…Many studies reporting the effects of light therapy on humans, in different pathological conditions, concern the irradiation by the application of ultraviolet (UV) lamp [1,2], infrared (IR) laser [3,4], Light Emitting Diode (LED) [5,6], and Polarized Polychromatic Incoherent Low Energy Radiation (PILER) [7][8][9][10][11]. All these sources showed light therapy exerts reparative capacity by modulating the production of cytokines and other soluble factors, and their main targets are fibroblasts from the skin [7].…”

Genome-wide gene expression study indicates the anti-inflammatory effect of polarized light in recurrent childhood respiratory disease

“…Besides an increase in absolute lymphocyte count, a recently published in-vivo study [3] also confirmed a significant elevation in the number of CD3 ? CD4 ?…”

“…In-vivo and in-vitro data [1][2][3] demonstrated that polarized light has a selective effect on the various cells of the immune response, as well as other biological model systems, in contrast to diffuse visible light of the same wavelength range and power density used as control. The experiments [2] proved that polarized light has a significant effect on the gene and protein expression of interleukin-6 (IL-6), a central regulatory molecule of acute inflammation, reducing IL-6 production in circulating blood monocytes while increasing that in human B lymphocytes.…”

Effect of 710-nm Visible Light Irradiation on Neuroprotection and Immune Function after Stroke

“…Our previous studies showed that the absolute count of total lymphocytes and CD3 + CD4 + T cells increased significantly after 28 days of exposure to polychromatic VIS (540–780 nm) irradiation in adult humans (18 males, 15 females) [41], and also specific 710-nm light irradiation to the whole body of animals increased T cell subset populations in the peripheral blood of rats [23]. Both previous studies suggest that a new phototherapeutic regimen might be promising for CD4 + T lymphocyte-mediated immune modulation therapy.…”