“…It is possible to speculate that these conditions resemble or even exacerbate off-training physical behaviors of athletes (Sperlich and Holmberg, 2017 ; Izzicupo et al, 2019 ). Studies on vascular, metabolic, and muscular adaptations to unloading (e.g., uninterrupted sitting and bed rest) as well as on post-injury conditions (Milsom et al, 2014 ) or the detrimental effects of the off-season (Suarez-Arrones et al, 2019 ) allow some speculations. Findings indicate that prolonged and uninterrupted sitting is associated with body fatness in highly trained athletes (Júdice et al, 2014 ); acute lower limbs dysfunction in healthy young subjects (Padilla and Fadel, 2017 ); increased sympathetic and renin–angiotensin system activity (Young and Leicht, 2011 ), plasma fibrinogen (Izzicupo et al, 2020 ), hematocrit, hemoglobin, and red blood cell count and a reduction in plasma volume (Howard et al, 2013 ); modified glucose and lipid metabolisms (Bergouignan et al, 2009 ; Stephens et al, 2011 ); changes in muscle size and architecture and tendon mechanical properties (De Boer et al, 2007 ; de Boer et al, 2008 ); muscle loss (Miles et al, 2005 ); and reductions in muscle strength, power, and rate of force development (Mujika and Padilla, 2001 ; De Boer et al, 2007 ; Bosquet et al, 2013 ; Rejc et al, 2018 ).…”