The effects of dexmedetomidine on liver ischemia–reperfusion injury in rats

The effect of dexmedetomidine against oxidative and tubular damage induced by renal ischemia reperfusion in rats

“…In the same study, it has been reported that SOD, CAT and GSH peroxidase (GSH-Px), enzyme activation have been increased. 17 Sugita et al 18 have reported that the dex infusion reduces the renal dysfunction developed by I/R during bilateral renal I/R, and also reduces renal parenchyma interleukin-6 (IL-6), inducible nitric oxide synthase (iNOS) and ICAM-1 mRNA expression. In another study, it has been observed that the dex application reduces kidney caspase 3, plasma ICAM-1 and monocyte chemo attractant protein-1 (MCP-1) levels; and these effects have been inhibited by atipamezole, which is a-2 antagonist.…”

Effects of antioxidant agents against cyclosporine-induced hepatotoxicity

“…An experienced histologist who was blinded to the treatment group semiquantitatively assessed the severity of liver damage in each sample according to the following criteria: sinusoidal dilatation, infiltration, congestion, vacuolization, and loss of glycogen deposition. For each sample, each of these observed parameters of hepatic damage was scored using a grading system with 0 representing absence of damage, 1 representing slight damage, 2 representing moderate damage, and 3 representing severe damage [12,16]. The total liver damage score was then calculated by summing the scores for each parameter; the total possible score was 15, which corresponded to the most severe level of liver damage.…”

Dexmedetomidine Alleviates Hyperoxia-Induced Acute Lung Injury via Inhibiting NLRP3 Inflammasome Activation

“…Recent studies have suggested that Dex also has anti-inflammatory, antioxidant, and anti-apoptosis effects [10-12]. Xu et al demonstrated that Dex could alleviate LPS-induced acute lung injury in mouse by restraining the inflammatory reactions [13].…”