The Effects of Diclofenac Suppository and Intravenous Acetaminophen and their Combination on the Severity of Postoperative Pain in Patients Undergoing Spinal Anaesthesia During Cesarean Section

Abstract

Results of this study indicates a significant effect of concomitant use of intravenous acetaminophen and diclofenac suppository on pain severity reduction and reducing the need for repeated doses of narcotics and prolonging the postoperative analgesia.

Comparative Analysis of Inpatient Costs for Obstetrics and Gynecology Surgery Patients Treated With IV Acetaminophen and IV Opioids Versus IV Opioid-only Analgesia for Postoperative Pain

“…Several approaches have been explored in this population, including the postoperative combination rectal diclofenac and intravenous (IV) acetaminophen as well as preoperative acetaminophen and adjunctive treatment with complementary therapies. [5][6][7][8] Using multiple agents or techniques with additive or even synergistic effects allows the use of lower doses to achieve effective analgesia, potentially reducing consequent opioid dependence while also reducing complications and associated longer LOSs. [9][10][11] The clinical success of such approaches across many clinical areas, coupled with the social and regulatory pressures of the opioid epidemic in the United States have resulted in increasing interest in expanding multimodal pain management options.…”

Comparing Transcervical Intrauterine Lidocaine Instillation with Rectal Diclofenac for Pain Relief During Outpatient Hysteroscopy: A Randomized Controlled Trial

“…El-Gamal and colleagues (18) assessed the analgesic efficacy of lidocaine dissolved in the distension medium compared to oral diclofenac before outpatient diagnostic hysteroscopy. The study was a randomized controlled trial including 44 nulliparous women schedules to undergo diagnostic office hysteroscopy.…”

Comparison the Effect of Paracetamol and Ketorolac on Pain Relief after Cesarean Section

“…In a study comparing the effect of paracetamol and ketorolac on postthyroidectomy pain control, it was reported that paracetamol may be an alternative to ketorolac for pain prevention in cases where NSAIDs are inappropriate [17]. In another study investigating the effect of intravenous diclofenac and acetaminophen suppositories and their combination on the severity of postoperative pain in patients undergoing spinal anesthesia during cesarean section, reported concomitant use of intravenous acetaminophen and diclofenac supplementation on pain relief and reduction the need for repeated doses of drugs and prolonged postoperative analgesia have a significant effect [18].…”

“…Cesarean section is one of the most common surgical procedures in women. Cesarean delivery is referred to as the birth of a fetus by cutting the abdominal wall and the uterine wall [1]. The rate of cesarean delivery around the world has steadily increased over the past two decades [2][3][4].…”