The effects of diet and gut microbiota on the regulation of intestinal mucin glycosylation

Qu, Dingwu; Wang, Gang; Yu, Leilei; Tian, Fengwei; Chen, Wei; Zhai, Qixiao

doi:10.1016/j.carbpol.2021.117651

Cited by 33 publications

(27 citation statements)

References 166 publications

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“…The phylogenetic tree was edited using the online tool iTOL (https: / / itol .embl .de/ ). Qu et al, 2021). The SLP are extracellular proteins that could act as structural components, virulence factors, or adhesion promoters.…”

Section: Adhesion Properties Of Kefir Microbiotamentioning

confidence: 99%

“…Together with antimicrobial peptides, antimicrobial molecules such as lysozyme and commensal microbiota represent the first line of defense against the colonization of pathogens (Liévin-Le Moal and Servin, 2006). Mucins are secreted by the goblet cells and are highly glycosylated proteins that secrete mucus through oligomerization; the glycan moieties act as ligands for bacterial receptors, and it has been reported that changes in the glycosylation pattern of these molecules could cause dysbiosis and inflammation, and promote bacterial infections (Monteagudo-Mera et al, 2019;Qu et al, 2021).…”

Section: Adhesion Properties Of Kefir Microbiotamentioning

confidence: 99%

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Invited review: Milk kefir microbiota—Direct and indirect antimicrobial effects

González‐Orozco

García‐Cano

Jiménez-Flores

et al. 2022

Journal of Dairy Science

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Kefir is a fermented dairy product with well recognized probiotic properties. Recently, consumer interest in fermented products with probiotic microorganisms has increased due to the accumulating evidence of the effects of kefir microorganisms on the modulation of gut microbiota and their antimicrobial activity. Although the health properties of kefir have been reviewed in other works, the present review addresses the antimicrobial effects of kefir microbiota and associated compounds. The antimicrobial activity of kefir microorganisms could derive from different mechanisms. The microorganisms' capacity to adhere to the intestinal epithelium, preventing the adhesion of pathogens, and their immunomodulation properties are among the mechanisms suggested. Bacteria and yeast isolated from kefir have been shown to have in vivo and in vitro antimicrobial activity against enteropathogenic bacteria and spoilage fungi. However, most reports have focused their approach on single-strain antimicrobial properties; evaluation of antimicrobial activity of cocultures of kefir microbiota and their potential mechanisms of action has been neglected. Kefir microbiota and associated compounds have shown promising antimicrobial effects; however, more research needs to be done to discern the mechanisms of action.

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Section: Adhesion Properties Of Kefir Microbiotamentioning

confidence: 99%

Section: Adhesion Properties Of Kefir Microbiotamentioning

confidence: 99%

Invited review: Milk kefir microbiota—Direct and indirect antimicrobial effects

González‐Orozco

García‐Cano

Jiménez-Flores

et al. 2022

Journal of Dairy Science

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“…In addition, IBD is usually accompanied by truncated O-glycans in intestinal epithelial cells, which may be related to glycosidase produced by microorganisms and oxidative stress caused by inflammation ( 51 ). The truncated intestinal sugar chain makes the mucosa thinner, and the SCFAs are reduced in IBD and cannot regulate mucin glycosylation normally ( 52 ). This makes mucin lose its stability.…”

Section: Interaction Between Commensal Bacteria and The Intestinal Barrier In Ibdmentioning

confidence: 99%

Interaction Between Commensal Bacteria, Immune Response and the Intestinal Barrier in Inflammatory Bowel Disease

et al. 2021

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In inflammatory bowel disease (IBD), intestinal mucosa cell and intestinal epithelial cell are severely damaged, and then their susceptibility to bacteria increases, so many commensal bacteria become pathogenic. The pathogenic commensal bacteria can stimulate a series of compensatory immune responses in the intestine. However, the immune response prevents the intestinal tract from restoring homeostasis, which in turn produces an indispensable inflammatory response. On the contrary, in IBD, the fierce inflammatory response contributes to the development of IBD. However, the effect of commensal bacteria on inflammation in IBD has not been clearly studied. Therefore, we further summarize the changes brought about by the changes of commensal bacteria to the inflammation of the intestines and their mutual influence. This article reviews the protective mechanism of commensal bacteria in healthy people and the mechanism of commensal bacteria and immune response to the destruction of the intestinal barrier when IBD occurs. The treatment and prevention of IBD are also briefly summarized.

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“…An increasing number of studies have demonstrated that gut microbiota can influence mucin glycosylation and mucosal homeostasis via glycosidases, metabolites, and bacterial components. In contrast, mucin glycans also influence the behavior of gut microbiota, including probiotic traits, energy acquisition and signal transmission (Qu et al, 2021). Taken together, this evidence elucidates the essential role of IECs in modulation of the gut microbiota and maintenance of homeostasis of the GIT through different signaling pathways, AMPs, and mucins.…”

Section: Regulation Of Gut Microbiota By Iecsmentioning

confidence: 65%

Crosstalk Between the Gut Microbiota and Epithelial Cells Under Physiological and Infectious Conditions

Zhou

Yuan

Yang

et al. 2022

Front. Cell. Infect. Microbiol.

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The gastrointestinal tract (GIT) is considered the largest immunological organ, with a diverse gut microbiota, that contributes to combatting pathogens and maintaining human health. Under physiological conditions, the crosstalk between gut microbiota and intestinal epithelial cells (IECs) plays a crucial role in GIT homeostasis. Gut microbiota and derived metabolites can compromise gut barrier integrity by activating some signaling pathways in IECs. Conversely, IECs can separate the gut microbiota from the host immune cells to avoid an excessive immune response and regulate the composition of the gut microbiota by providing an alternative energy source and releasing some molecules, such as hormones and mucus. Infections by various pathogens, such as bacteria, viruses, and parasites, can disturb the diversity of the gut microbiota and influence the structure and metabolism of IECs. However, the interaction between gut microbiota and IECs during infection is still not clear. In this review, we will focus on the existing evidence to elucidate the crosstalk between gut microbiota and IECs during infection and discuss some potential therapeutic methods, including probiotics, fecal microbiota transplantation (FMT), and dietary fiber. Understanding the role of crosstalk during infection may help us to establish novel strategies for prevention and treatment in patients with infectious diseases, such as C. difficile infection, HIV, and COVID-19.

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The effects of diet and gut microbiota on the regulation of intestinal mucin glycosylation

Cited by 33 publications

References 166 publications

Invited review: Milk kefir microbiota—Direct and indirect antimicrobial effects

Invited review: Milk kefir microbiota—Direct and indirect antimicrobial effects

Interaction Between Commensal Bacteria, Immune Response and the Intestinal Barrier in Inflammatory Bowel Disease

Crosstalk Between the Gut Microbiota and Epithelial Cells Under Physiological and Infectious Conditions

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