The effects of dietary and physical activity interventions on tinnitus symptoms: An RCT

Özbey, Ümüş; Uçar, Aslı; Aydoğan, Zehra; Tokgöz-Yılmaz, Suna; Beton, Süha

doi:10.1016/j.anl.2022.04.013

Cited by 6 publications

(22 citation statements)

References 32 publications

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“…One study was excluded as the authors only reported baseline depression scores and not postintervention or mean pre–post change score data for depression and did not respond when contacted [ 41 ]. Overall, 13 RCTs met the eligibility criteria and were included in the meta-analyses [ [42] , [43] , [44] , [45] , [46] , [47] , [48] , [49] , [50] , [51] , [52] , [53] , [54] ]. Full PRISMA flow chart of database searches and included studies in the systematic review and meta-analysis are shown in Figure 1 .…”

Section: Resultsmentioning

confidence: 99%

“…Participant numbers for each study ranged from n = 44 [ 53 ] to n = 439 [ 45 ]. Over half ( n = 9, 56%) of the studies included participants with overweight or obesity [ [45] , [46] , [47] , [48] , [49] , [50] , [51] , [52] , [53] ] and one study included participants with overweight or obesity and/or previous diagnoses of T2DM [ 42 ]. One study included participants with high cholesterol and high blood pressure [ 43 ], one study with participants with high blood pressure only [ 54 ], and another study with participants with hyperlipidemia [ 44 ] .…”

Section: Resultsmentioning

confidence: 99%

“…One study included participants with high cholesterol and high blood pressure [ 43 ], one study with participants with high blood pressure only [ 54 ], and another study with participants with hyperlipidemia [ 44 ] . Seven studies included a combination of males and females [ 42 , [46] , [47] , [48] , 50 , 51 , 54 ], 3 studies included only females [ 45 , 49 , 53 ], and 3 included only males [ 43 , 44 , 52 ]. The duration of the interventions ranged from 1 mo [ 54 ] to 3 y [ 43 ].…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Diet Overall and Hypocaloric Diets Are Associated With Improvements in Depression but Not Anxiety in People With Metabolic Conditions: A Systematic Review and Meta-Analysis

Paris,

Daly,

Abbott

et al. 2024

Advances in Nutrition

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Diet Overall and Hypocaloric Diets Are Associated With Improvements in Depression but Not Anxiety in People With Metabolic Conditions: A Systematic Review and Meta-Analysis

Paris,

Daly,

Abbott

et al. 2024

Advances in Nutrition

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“…These non-negligible factors may account for the inconsistent findings. Two randomized controlled trials found benefits of diet and/or physical activity in reducing the severity of tinnitus (Özbey-Yücel et al 2021; Özbey-Yücel et al 2022). Nevertheless, both trials were conducted on obese patients, and the severity of tinnitus was also significantly reduced in the control group, although the degree of reduction was less than that in the diet/physical activity group.…”

Section: Discussionmentioning

confidence: 99%

“…Carpenter-Thompson et al (2015) focused on the effect of physical activity intensity on tinnitus severity; therefore, the relationship between physical activity and tinnitus development was not explored. Özbey-Yücel et al (2022) also found that physical activity decreased tinnitus symptoms, albeit the result was limited to obese patients.…”

Section: Introductionmentioning

confidence: 97%

Associations Between Physical Activity, Tinnitus, and Tinnitus Severity

et al. 2022

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Objectives: To examine the associations between physical activity and tinnitus development and physical activity and tinnitus severity in a large representative sample of US adults.Design: Data were obtained from 3826 eligible participants (20 to 69 years) in the National Health and Nutrition Examination Survey between 2015 and 2016. Physical activity was assessed using a Global Physical Activity Questionnaire. We used multivariable logistic regression to test the associations of physical activity (without physical activity, with physical activity) and amount of physical activity (min/week, in quartiles) with tinnitus symptoms. Adults with depressive symptoms were excluded, and the models were controlled for relevant sociodemographic, lifestyle, and health-related covariates. A restricted cubic spline was used to explore the dose-response relationship between the amount of physical activity and tinnitus.Results: Overall, 12.8% of the population who engaged in physical activity reported tinnitus, compared with 18.5% of the population who did not (p = 0.005). Subgroup analysis based on the amount of physical activity showed that participants who performed physical activity (150 to 300, 310 to 540, and 550 to 4800 min/week) had lower risks of tinnitus than those with no physical activity (odds ratio = 0.72, 0.56, and 0.62, respectively), after adjusting for covariates. However, no correlation was observed between physical activity and tinnitus severity in the present study. The dose-response analysis showed a nonlinear relationship (P for nonlinearity = 0.04) between the amount of physical activity and the risk of tinnitus.Conclusions: Physical activity may be associated with a reduced risk of tinnitus. Further research using a longitudinal design is required to confirm these findings and clarify the direction of causation.

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The causal relationship between anxiety and tinnitus severity: a Mendelian randomization study

Yang,

Ding

2024

Egypt J Med Hum Genet

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Background The link between anxiety and tinnitus severity has garnered significant scholarly interest, with numerous studies identifying a positive correlation. Despite this, the genetic basis of this relationship remains underexplored. Leveraging publicly accessible GWAS data, this study employs Mendelian randomization to elucidate the genetic causality between anxiety and tinnitus severity. Methods This research analyzed single nucleotide polymorphisms (SNPs) related to anxiety and tinnitus severity from the UK Biobank, utilizing aggregated data from genome-wide association studies (GWAS). Instrumental variables linked to anxiety were meticulously selected. The study implemented several Mendelian randomization techniques, including “mr_ivw,” “mr_egger_regression,” “mr_weighted_median,” “mr_simple_mode,” and “mr_weighted_mode,” to assess the causal impact of anxiety on tinnitus risk through odds ratios (ORs). Sensitivity analyses, including MR-Egger and the leave-one-out method, were conducted to ensure result stability. The F-value was also calculated to ascertain the strength of the instrumental variables. Results Analysis identified five SNPs as instrumental variables. The calculated ORs and 95% confidence intervals from MR-Egger regression, weighted median, and inverse variance weighting showed no statistically significant causal relationship between anxiety and severe tinnitus, with all P-values exceeding 0.05. This lack of statistical significance, consistent across various methods, indicates no genetic causality between anxiety and tinnitus severity. Furthermore, no evidence of heterogeneity (P = 0.80) or horizontal pleiotropy (P = 0.31) was found, reinforcing the robustness of the instrumental variables (F > 10). Conclusion Our Mendelian randomization analysis reveals no genetic causality between anxiety and tinnitus severity, suggesting the need for further research into the multifaceted etiology of tinnitus.

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The effects of dietary and physical activity interventions on tinnitus symptoms: An RCT

Cited by 6 publications

References 32 publications

Diet Overall and Hypocaloric Diets Are Associated With Improvements in Depression but Not Anxiety in People With Metabolic Conditions: A Systematic Review and Meta-Analysis

Diet Overall and Hypocaloric Diets Are Associated With Improvements in Depression but Not Anxiety in People With Metabolic Conditions: A Systematic Review and Meta-Analysis

Associations Between Physical Activity, Tinnitus, and Tinnitus Severity

The causal relationship between anxiety and tinnitus severity: a Mendelian randomization study

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