The effects of dietary calcium and chlordecone on cholinesterase, triglycerides, low density lipoproteins, and cholesterol in serum of rat

Abstract

Male, Sprague-Dawley rats were treated with 0, 1, 10, 50, 100 ppm chlordecone (Cd) mixed in calcium-sufficient (Ca-S) or calcium-deficient (Ca-D) diet for 15 days. A significant decrease in body weight gain was observed in 100 ppm of Cd-treated rats. Cholinesterase (ChE) activity was significantly decreased in serum of Ca-D rats. Chlordecone did not alter serum ChE activity in both Ca-S and Ca-D rats. However, Cd decreases serum triglycerides, low density lipoproteins (LDL) and cholesterol in both Ca-S and Ca-D rats. Rats fed with Ca-S or Ca-D diet exhibited differential sensitivity to Cd-toxicity. Decreased levels of serum triglycerides, LDL and cholesterol suggest that Cd might interfere in lipid metabolism.

Calcium deficiency modifies polyunsaturated fatty acid metabolism in growing rats

“…A series of experimental reports carried out either in animals (1)(2)(3) or in human populations (4)(5)(6)(7)(8)(9) shows a clear correlation between serum concentrations of metal cations and cardiovascular diseases. The effect of dietary manipulations of mineral components on the development of atherosclerosis and related diseases suggests that the nonsaturated fatty acid metabolism is clearly influenced by its metabolic actions.…”

Chlordecone, a mixed pregnane X receptor (PXR) and estrogen receptor alpha (ERα) agonist, alters cholesterol homeostasis and lipoprotein metabolism in C57BL/6 mice

“…Prior reports indicate that a single dose of CD, an OC insecticide, alters tissue distribution of exogenous CH in mice and rats (Carpenter and Curtis 1991; Gilroy et al, 1994; Lee et al, 2008). Subsequent experiments and other work suggests that CD also modulates other aspects of lipid homeostasis (Carpenter et al, 1996; Chetty et al, 1993). However, molecular mechanisms underlying these observations are unclear.…”