The Effects of Dietary Flavonoid Supplementation on the Antioxidant Status of Laying Hens

İskender, Hatice; Yenice, Güler; Dokumacıoğlu, Eda; Kaynar, Özgür; Hayırlı, A.; Kaya, Arzu

doi:10.1590/1806-9061-2016-0356

Cited by 46 publications

(30 citation statements)

References 33 publications

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“…One of them is the upregulation of the Nrf2 gene expression which enhances antioxidant enzymes activity, thus decreasing oxidative stress (Parhiz, Roohbakhsh, Soltani, Rezaee, & Iranshahi, ). The positive antioxidant capacity of hesperidin had been previously described for production animals, such as poultry (orange peel 0.04%—Akbarian, Golian, Kermanshahi, Smet, & Michiels, ; hesperidin 0.002%—Ognik, Cholewińska, Sembratowicz, Grela, & Czech, ) and laying hens (0.05% hesperidin—Iskender et al, ), and also for rats (0.04% orange peel aqueous extract—Selmi, Rtibi, Grami, Sebai, & Marzouki, ). Further studies assessing hesperidin, reactive oxygen metabolites and the biological antioxidant potential could help in understanding OPF on Nile tilapia antioxidant capacity.…”

Section: Discussionmentioning

confidence: 78%

Orange peel fragment improves antioxidant capacity and haematological profile of Nile tilapia subjected to heat/dissolved oxygen‐induced stress

et al. 2018

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This study evaluated the ability of orange peel fragment (OPF) to act as a functional feedstuff, influencing growth, haematological profile, and antioxidant enzyme activity of Nile tilapia subjected heat/dissolved oxygen-induced stress (HDOIS). A group of 440 male Nile tilapia (31.7 g ± 0.34) was randomly distributed in 40 250-L aquaria (11 fish/tank) and fed five practical diets with graded levels of OPF at 0%, 0.2%, 0.4%, 0.6%, and 0.8% for 70 days. The diets were formulated to contain 30% crude protein and 18 MJ/kg crude energy. After the feeding period, growth performance was evaluated and six fish per treatment were sampled for haematological profile and antioxidant enzyme activity, before and after HDOIS. Then, fish were subjected to HDOIS (32°C/2.3 mg/L dissolved oxygen) for three days and the same haematological profile and antioxidant enzyme activity were determined. There was no effect of OPF on the haematological profile, either before or after HDOIS. The polynomial regression model was used to express the relationship between antioxidant enzymes activity and OPF supplementation level. The maximum activity of superoxide dismutase, catalase, and glutathione peroxidase was reached at 0.66%, 0.63%, and 0.68% of OPF respectively. Results of the present study suggest that a dietary supplementation level of 0.63%-0.68% of orange peel fragment was appropriate to maintain Nile tilapia haematological profile and improve its antioxidant capacity under HDOIS. K E Y W O R D Santioxidant system, orange by-product, orange peel fragment, Oreochromis niloticus, temperature stress

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Section: Discussionmentioning

confidence: 78%

Orange peel fragment improves antioxidant capacity and haematological profile of Nile tilapia subjected to heat/dissolved oxygen‐induced stress

et al. 2018

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“…Others manuscripts show the importance of a balance between the production and elimination of free radicals for a good productive performance of birds in posture [ 31 , 32 , 33 ]. We did not observe any improvement in the percentage of posture due to cinnamon supplementation; however, animals fed cinnamon supplementation presented better conversion by egg mass.…”

Section: Discussionmentioning

confidence: 99%

The role of cinnamon as a modulator of the expression of genes related to antioxidant activity and lipid metabolism of laying quails

et al. 2017

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Since cinnamon has vitamins and minerals in addition to antioxidants compounds in its chemical composition studies have shown the potential of cinnamon supplementation on some important characteristics in the performance of birds. Thus, this study was conducted under the hypothesis that the inclusion of cinnamon in the laying quail diet could influence the performance of the birds through the expression of genes related to antioxidant activity and lipid metabolism. To test this hypothesis, 144 Japanese quail (Coturnix japonica) with an initial age of 18 weeks and average weight of 133g were distributed in a completely randomized design with two treatments: no cinnamon supplementation (NCS—control group) and with supplementation of 9g/kg of cinnamon powder (CPS). The experiment lasted for 84 days. At the end of the experimental period, six animals from each treatment were euthanized by cervical dislocation, blood was collected and organs weighed. Liver tissue was collected for gene expression and biochemical analyses. We observed a significant effect of cinnamon inclusion on the weight of the pancreas (P = 0.0418), intestine (P = 0.0209) and ovary (P = 0.0389). Lower weights of the pancreas and intestine, and a higher ovary weight was observed in birds receiving the CPS diet. Quails fed with cinnamon supplementation also had better feed conversion per egg mass (2.426 g /g, P = 0.0126), and higher triglyceride (1516.60 mg/dL, P = 0.0207), uric acid (7.40 mg/dL, P = 0.0003) and VLDL (300.40 mg/dL, P = 0.0252) contents. A decreased content of thiobarbituric acid reactive substances (TBARS) and lower catalase activity was observed in the liver of quails from the CPS diet (0.086 nmoles/mg PTN, and 2.304 H2O2/min/mg PTN, respectively). Quails from the CPS group presented significantly greater expression of FAS (fatty acid synthase, 36,03 AU), ACC (Acetyl-CoA Carboxylase, 31.33 AU), APOAI (apolipoprotein A-I, 803,9 AU), ESR2 (estrogen receptor 2, 0.73 AU) SOD (superoxide dismutase, 4,933.9 AU) and GPx7 (glutathione peroxidase 7, 9.756 AU) than quails from the control group. These results allow us to suggest that cinnamon powder supplementation in the diet of laying quails can promote balance in the metabolism and better performance through the modulation of antioxidant activity and the expression of genes related to lipid metabolism.

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“…Chemically, flavonoids have hydroxyl groups and a highly conjugated π-electron system, which allows them to act as free radical scavengers [80]. Antioxidant activity of flavonoids [16,20,33,76,81], chelating properties [20], makes them acts as protective agents against free radicals [26,79]. In the body, anti-oxidants protect the human body from free radicals oxidation [17] thereby retarding the progress of many chronic diseases.…”

Section: Anti-oxidant Activitymentioning

confidence: 99%

Flavonoids: isolation, characterization, and health benefits

Ekalu¹,

Habila

2020

Beni-Suef Univ J Basic Appl Sci

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Background The unique and vast pharmacological activities of flavonoids have made them of research interest. This led to the use of various techniques to isolate and characterize them, intending to determine their potential health benefits. Main text The medicinal values of plant-based flavonoids that this literature review tends to summarize the pharmacological activities of these secondary metabolites from 22 selected plant families. The pharmacological shreds of evidence reported in the literature have proven that flavonoids have shown anti-cancer, anti-microbial, anti-oxidant, anti-inflammatory, anti-fungal, anti-ulcer, and anti-edematogenic activities. Out of these, 30% showed to have anti-oxidant activity, key in protecting the body against free radicals. Besides, 18% of the references showed anti-microbial and anti-cancer activities. Further literature reports indicated that flavonoids from these families exhibited anti-inflammatory and anti-edematogenic (9%), anti-viral and anti-ulcer (5%), anti-fungal, anti-nociceptive, and anti-histamine (2%). Conclusion The pharmacological activities of flavonoids from the various sources reviewed in this study show that the secondary metabolites could provide a scaffold for the development of potent anti-cancer drugs in the future.

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The Effects of Dietary Flavonoid Supplementation on the Antioxidant Status of Laying Hens

Cited by 46 publications

References 33 publications

Orange peel fragment improves antioxidant capacity and haematological profile of Nile tilapia subjected to heat/dissolved oxygen‐induced stress

Orange peel fragment improves antioxidant capacity and haematological profile of Nile tilapia subjected to heat/dissolved oxygen‐induced stress

The role of cinnamon as a modulator of the expression of genes related to antioxidant activity and lipid metabolism of laying quails

Flavonoids: isolation, characterization, and health benefits

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