“…Besides the individual effects of DHA and EPA, the ratio of these two LC-PUFAs in diets has also been demonstrated to exert significant influences on a range of physiological processes in marine fish (Ibeas, Cejas, Fores, Bad ıa, G omez & Lorenzo Hern andez 1997;Rodr ıguez, P erez, D ıaz, Izquierdo, Fern andez-Palacios & Lorenzo 1997;Wu, Ting & Chen 2002;Dantagnan, B orquez, Hern andez & Izquierdo 2010;Trushenski, Schwarz, Bergman, Rombenso & Delbos 2012). However, its importance was relatively neglected compared to the total amount of n-3 LC-PUFAs (Sargent, Bell, Mcevoy, Tocher & Estevez 1999;Kim, Lee, Park, Bai & Lee 2002;Lee, Lee & Kim 2003;Skalli & Robin 2004;Hamre & Harboe 2008;Wilson 2009;Lund & Steenfeldt 2011;ØStbye, Kjaer, Rør a, Torstensen & Ruyter 2011;Zuo, Ai, Mai, Xu, Wang, Xu, Liufu & Zhang 2012b). The limited amount of work performed to date has suggested that dietary DHA and EPA had different efficiency in influencing bio-functions of fish such as vision (Navarro, McEvoy, Bell, Amat, Hontoria & Sargent 1997;Noffs et al 2009), pigmentation (Villalta et al 2008;Vizca ıno-Ochoa et al 2010) and reproduction (Mazorra, Bruce, Bell, Davie, Alorend, Jordan, Rees, Papanikos, Porter & Bromage 2003), whereas little information was available regarding the difference between DHA and EPA in modulation of fish health such as immunity and stress resistance (Wu, Ting & Chen 2003;Zuo, Ai, Mai, Xu, Wang, Xu, Liufu & Zhang 2012a).…”