The effects of different acetylcholinesterase inhibitors on EEG patterns in patients with Alzheimer’s disease: A systematic review

Arjmandi-Rad, Shirin; Vestergaard Nieland, John D.; Goozee, Kathryn G.; Vaseghi, Salar

doi:10.1007/s10072-023-07114-y

Cited by 5 publications

(1 citation statement)

References 135 publications

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“…Previous studies have reported slower IAFs in schizophrenia patients [ 61 , 62 ] and decreased SSVEP across frequencies and electrode locations in schizophrenia patients compared to healthy controls [ 5 ]. Moreover, variations in the IAF have been found among healthy controls, individuals with mild cognitive impairment, and Alzheimer’s disease (AD) patients [ 63 , 64 , 65 ]. By using visual stimulation at 15 Hz, the authors of [ 66 ] identified altered SSVEP in patients on the AD spectrum, with SSVEP amplitude predicting cognitive performance (i.e., Mini-Mental State Examination).…”

Section: Discussionmentioning

confidence: 99%

A High-Resolution LED Stimulator for Steady-State Visual Stimulation: Customizable, Affordable, and Open Source

Otero,

Prieur-Coloma,

El-Deredy

et al. 2024

Sensors

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Visually evoked steady-state potentials (SSVEPs) are neural responses elicited by visual stimuli oscillating at specific frequencies. In this study, we introduce a novel LED stimulator system explicitly designed for steady-state visual stimulation, offering precise control over visual stimulus parameters, including frequency resolution, luminance, and the ability to control the phase at the end of the stimulation. The LED stimulator provides a personalized, modular, and affordable option for experimental setups. Based on the Teensy 3.2 board, the stimulator utilizes direct digital synthesis and pulse width modulation techniques to control the LEDs. We validated its performance through four experiments: the first two measured LED light intensities directly, while the last two assessed the stimulator’s impact on EEG recordings. The results demonstrate that the stimulator can deliver a stimulus suitable for generating SSVEPs with the desired frequency and phase resolution. As an open source resource, we provide comprehensive documentation, including all necessary codes and electrical diagrams, which facilitates the system’s replication and adaptation for specific experimental requirements, enhancing its potential for widespread use in the field of neuroscience setups.

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Section: Discussionmentioning

confidence: 99%

A High-Resolution LED Stimulator for Steady-State Visual Stimulation: Customizable, Affordable, and Open Source

Otero,

Prieur-Coloma,

El-Deredy

et al. 2024

Sensors

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Design, synthesis of antipyrine-based Schiff bases and investigation of their cholinesterase and carbonic anhydrase activities by in vitro and in silico approaches

Çakmak,

Başaran,

Türkmenoğlu

et al. 2025

Journal of Molecular Structure

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Network Pharmacology and Molecular Docking Perspectives into Lignans for Alzheimer's Disease Treatment

Şirin,

Niğdelioğlu Dolanbay

2024

Kahramanmaraş Sütçü İmam Üniversitesi Tarım Ve Doğa Dergisi

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Alzheimer’s Disease (AD) is a debilitating neurodegenerative condition with limited treatment options. Lignans, a class of naturally occurring polyphenols found in various plants, have been shown to have the potential to modulate pathways associated with AD pathology. In this study, we used network pharmacology and molecular docking to investigate the therapeutic potential of lignans against AD by targeting specific proteins involved in disease progression. Our established interaction network includes key proteins such as EGFR, HSP90AA1, BCL2, HSP90AB1, IL6, JUN, ESR1, PIK3CA, ERBB2, and PIK3R1. Molecular docking studies have revealed how lignans interact with these proteins and highlighted their potential to influence AD through mechanisms such as inflammation modulation, apoptosis regulation, and signal transduction pathways. The results suggest that lignans have significant binding abilities to these targets, potentially inhibiting their activity and thus alleviating AD symptoms by reducing amyloid-beta accumulation and tau phosphorylation. These findings support the viability of lignans as a basis for the development of new AD therapies and call for further in vivo studies to confirm their efficacy and safety. This integrated approach underscores the value of combining network pharmacology and molecular docking in the search for new therapeutic agents against complex diseases such as AD.

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The effects of different acetylcholinesterase inhibitors on EEG patterns in patients with Alzheimer’s disease: A systematic review

Cited by 5 publications

References 135 publications

A High-Resolution LED Stimulator for Steady-State Visual Stimulation: Customizable, Affordable, and Open Source

A High-Resolution LED Stimulator for Steady-State Visual Stimulation: Customizable, Affordable, and Open Source

Design, synthesis of antipyrine-based Schiff bases and investigation of their cholinesterase and carbonic anhydrase activities by in vitro and in silico approaches

Network Pharmacology and Molecular Docking Perspectives into Lignans for Alzheimer's Disease Treatment

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