The effects of different antihypertensive drugs on pain and joint space width of knee osteoarthritis – A comparative study with data from Osteoarthritis Initiative

Li, Mingyang; Zeng, Yi; Nie, Yong; Wu, Yuangang; Liu, Yuan; Wu, Limin; Xu, Jiawen; Shen, Bin

doi:10.1111/jch.14362

Cited by 12 publications

(8 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…9,18 A systematic review did not find associations between calcium channel blocker use and migraine outcomes. 18 However, a multicenter cohort study of people with knee osteoarthritis found associations between calcium channel blocker use and worse pain outcomes, 52 consistent with the current study. In contrast, an unpublished agnostic drug repurposing MR study of pain intensity irrespective of pain location suggested potential analgesic effects of calcium channel blockers.…”

Section: Discussionsupporting

confidence: 88%

Repurposing Antihypertensive and Statin Medications for Spinal Pain

Suri,

Elgaeva,

Williams

et al. 2023

Spine

View full text Add to dashboard Cite

Study Design: Mendelian randomization (MR) study Objective: To examine whether antihypertensive medications (beta-blockers, calcium channel blockers, and angiotensin-converting enzyme [ACE] inhibitors) and statins can be repurposed to prevent or treat spinal pain (back or neck pain). Summary of Background Data: Observational studies and a recent MR study have found associations between elevated blood pressure and greater risk of back pain. Observational studies have found associations between hyperlipidemia and statin use, and greater risk of back pain. No prior MR studies have examined the effects of antihypertensives or statins on spinal pain. Methods: This was a two-sample MR study using publicly available summary statistics from large-scale genome-wide association studies (GWAS). Sample sizes in exposure GWASs were n=757,601 (systolic blood pressure) and n=173,082 (low density lipoprotein[LDL] cholesterol), and n=1,028,947 for the outcome GWAS of spinal pain defined as health care seeking for any spinal pain-related diagnosis. Genes and cis-acting variants were identified as proxies for the drug targets of interest. MR analyses used inverse-variance weighted meta-analysis. The threshold for statistical significance after correction for multiple testing was P<0.0125. Results: No statistically significant associations of these medications with spinal pain were found. However, findings were suggestive of a protective effect of beta blockers on spinal pain risk (odds ratio [OR] 0.84, 95% confidence interval [CI] 0.72 to 0.98; P=0.03), and calcium channel blockers on greater spinal pain risk (OR 1.12, 95% CI 1.02 to 1.24; P=0.02). Conclusions: A protective effect of beta-blockers on spinal pain was suggested in the current study, consistent with findings from observational studies of various other pain phenotypes. The detrimental effect of calcium channel blockers on spinal pain suggested in the current study must be interpreted in the context of conflicting directions of effect on non-spinal pain phenotypes in other observational studies.

show abstract

Section: Discussionsupporting

confidence: 88%

Repurposing Antihypertensive and Statin Medications for Spinal Pain

Suri,

Elgaeva,

Williams

et al. 2023

Spine

View full text Add to dashboard Cite

show abstract

“…By analyzing the effects of different classes of antihypertensive drugs on pain and joint space width among 1945 patients who used antihypertensive drugs from the Osteoarthritis Initiative project, it has been shown that, among females, the users of calcium channel blockers exhibited significantly higher pain scores than the groups using beta-blockers and angiotensin receptor blockers. Compared to the common antihypertensive drugs (beta-blockers, ACE inhibitors, angiotensin receptor blockers, and thiazide diuretics), calcium channel blockers were associated with reduced joint space width, higher replacement rates, and higher pain scores [ 34 ]. An antinociceptive effect has been demonstrated for the beta blocker bupranolol in a mouse model of chronic pain [ 35 ].…”

Section: Therapeutic Considerations In Metabolic Knee Osteoarthritismentioning

confidence: 99%

Knee Osteoarthritis—How Close Are We to Disease-Modifying Treatment: Emphasis on Metabolic Type Knee Osteoarthritis

Lambova

2023

Life

View full text Add to dashboard Cite

show abstract

“…Beta-blockers have been shown to be associated with lower WOMAC scores and statistically significantly lower risk of joint pain, whereas other authors detected no evidence of analgesic effect. 131,132 Calcium channel blockers, on the other hand, have been associated with higher pain scores and a higher prevalence of joint replacement. [132][133][134] What is more concerning is the idea that calcium channel blockers may accelerate the process of OA by impairing the proliferation of chondrocytes.…”

Section: Antihypertensivesmentioning

confidence: 99%

“…131,132 Calcium channel blockers, on the other hand, have been associated with higher pain scores and a higher prevalence of joint replacement. [132][133][134] What is more concerning is the idea that calcium channel blockers may accelerate the process of OA by impairing the proliferation of chondrocytes. 135 The evidence is extremely limited on the use of these classes of medication for knee pain, and recommendations cannot be made for or against their use.…”

Section: Antihypertensivesmentioning

confidence: 99%

Consensus Guidelines on Interventional Therapies for Knee Pain (STEP Guidelines) from the American Society of Pain and Neuroscience

Hunter¹,

Deer²,

Jones³

et al. 2022

JPR

View full text Add to dashboard Cite

Knee pain is second only to the back as the most commonly reported area of pain in the human body. With an overall prevalence of 46.2%, its impact on disability, lost productivity, and cost on healthcare cannot be overlooked. Due to the pervasiveness of knee pain in the general population, there are no shortages of treatment options available for addressing the symptoms. Ranging from physical therapy and pharmacologic agents to interventional pain procedures to surgical options, practitioners have a wide array of options to choose from – unfortunately, there is no consensus on which treatments are “better” and when they should be offered in comparison to others. While it is generally accepted that less invasive treatments should be offered before more invasive ones, there is a lack of agreement on the order in which the less invasive are to be presented. In an effort to standardize the treatment of this extremely prevalent pathology, the authors present an all-encompassing set of guidelines on the treatment of knee pain based on an extensive literature search and data grading for each of the available alternative that will allow practitioners the ability to compare and contrast each option.

show abstract

The effects of different antihypertensive drugs on pain and joint space width of knee osteoarthritis – A comparative study with data from Osteoarthritis Initiative

Cited by 12 publications

References 38 publications

Repurposing Antihypertensive and Statin Medications for Spinal Pain

Repurposing Antihypertensive and Statin Medications for Spinal Pain

Knee Osteoarthritis—How Close Are We to Disease-Modifying Treatment: Emphasis on Metabolic Type Knee Osteoarthritis

Consensus Guidelines on Interventional Therapies for Knee Pain (STEP Guidelines) from the American Society of Pain and Neuroscience

Contact Info

Product

Resources

About