The Effects of Different Exercise Modalities in Alzheimer’s Disease

Özbeyli, Dilek; Çakır, Özgür Kasımay

doi:10.5152/clinexphealthsci.2017.230

Cited by 3 publications

(1 citation statement)

References 42 publications

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“…Besides, RE and AE therapies may help do daily activities and enhance physical ability in AD patients. Eventually, exercise therapy regimens may assist treatment options and slow AD progression without side effects ( Özbeyli & Kasımay Çakır, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Effects of Eight Weeks of Resistance Exercises on Expression of Neurotrophins and Trk Receptors in Alzheimer Model Male Wistar Rats

Jafarzadeh

Shakerian

Farbood

et al. 2021

BCN

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This study aims to evaluate the effects of eight weeks of resistance exercises on expression of neurotrophins and Trk receptors in Alzheimer model male Wistar rats. For this purpose, 32 mature male Wistar rats with mean weights of 230 to 280 g were chosen and divided into Alzheimer and Sham groups. Rats in the Sham group received normal saline while rats in the Alzheimer group received STZ via intraventricular injection. These rats were then divided into the following four subgroups: 1. Resting Sham, 2. Exercising Sham, 3. Resting Alzheimer, and 4. Exercising Alzheimer. The two exercising rat subgroups, exercised three times a week for a period of eight weeks. A weight was attached to their tails and they had to carry this weight on a 26-step ladder in each cycle. Resting groups were handled every day to minimize the effects of stress level. At the end of the 8th week and 24 hours after the last exercise session (to avoid the effects of the last exercise session), the rats were put under deep anesthesia and scarified by head separation. Hippocampus tissues were precisely extracted and samples were sent to laboratory for molecular and cellular tests. In order to investigate gene expression, Quantitative RT-PCR was used. Results of the tests for comparing the means of BDNF, NT3, NGF, TrkA, and TrkB in two rat groups showed that with error levels of less than 5% and confidence of over 95%, there is a significant difference in the amounts of BDNF, NT3, NGF, TrkA, and TrkB between exercising rats and resting rats. These amounts were much higher in exercising Alzheimer rats group. Eight weeks of resistance exercises increased the expression of BDNF, NT3, and NGF genes as well as TrkA and TrkB receptors in Alzheimer model Wistar rats.

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Section: Introductionmentioning

confidence: 99%

Effects of Eight Weeks of Resistance Exercises on Expression of Neurotrophins and Trk Receptors in Alzheimer Model Male Wistar Rats

Jafarzadeh

Shakerian

Farbood

et al. 2021

BCN

View full text Add to dashboard Cite

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Cognitive decline prevention in offspring of Pb+2 exposed mice by maternal aerobic training and Cur/CaCO3@Cur supplementations: In vitro and in vivo studies

Amooei

Meshkati

Nasiri

et al. 2021

Ecotoxicology and Environmental Safety

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The Effectiveness of Centella asiatica Extract and Aerobic Exercise on Plasma Levels of Amyloid Beta-42 and Phosphorylated Tau in Older Women with Dementia

Fitriana,

Adnyana,

Anggadiredja

et al. 2024

International Journal of Disabilities Sports and Health Sciences

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Urgency: Effect of Centella asiatica (CA) and aerobic exercise on Amyloid beta-42 (Aβ42) and phosphorylated tau (p-tau) as biomarkers of dementia is not yet known. Objectives: This study aimed to analyze the effect of CA, aerobic exercise, and their combination on Aβ42 and p-tau in older women with dementia. Design: It was a 24-week randomized, double-blind controlled trial. Partisipant: Subjects were divided into four groups: the Centella asiatica group (CA, 1x500 mg/day, n = 16), the aerobic exercise group (AE, 3x60 minutes/week, n = 16), the CA-AE combination group (1x500 mg/day and exercise, n = 15), and the placebo group (n = 15). Instruments: The dementia screening test used the Mini Mental State Examination (Intraclass correlation coefficients : ranging from 0.60 to 0.93, sensitivity of 88.3%) and Clinical Dementia Rating questionnaires (sensitivity 93.6% and specificity 100%). The Wilcoxon, Kruskal-Wallis, and Mann-Whitney tests were used to analyze the data. Results: Plasma amyloid beta-42 showed an increase in all groups: CA (p<0.001), AE (p=0.001), CA-AE combination (p<0.001), and placebo (p<0.001). Meanwhile, plasma p-tau also decreased in CA (p<0.001), AE (p<0.001), and CA-AE combination (p=0.001). The Mann-Whitney test showed that Centella asiatica caused the highest increase in Aβ42 (∆=233.5; p<0.001). Conclusion: This study indicate that Centella asiatica, aerobic exercise, and the CA-AE combination were effective in improving plasma Aβ42 and decreasing p-tau in older women with dementia. Contributions: This study can be an alternative therapy for the prevention and treatment of cognitive decline. Research with a larger sample size is recommended.

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The Effects of Different Exercise Modalities in Alzheimer’s Disease

Cited by 3 publications

References 42 publications

Effects of Eight Weeks of Resistance Exercises on Expression of Neurotrophins and Trk Receptors in Alzheimer Model Male Wistar Rats

Effects of Eight Weeks of Resistance Exercises on Expression of Neurotrophins and Trk Receptors in Alzheimer Model Male Wistar Rats

Cognitive decline prevention in offspring of Pb+2 exposed mice by maternal aerobic training and Cur/CaCO3@Cur supplementations: In vitro and in vivo studies

The Effectiveness of Centella asiatica Extract and Aerobic Exercise on Plasma Levels of Amyloid Beta-42 and Phosphorylated Tau in Older Women with Dementia

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