The effects of DNA repair polymorphisms on chromosome aberrations in the population of Kazakhstan

Djansugurova, Leyla; Altynova, Nazym; Cherednichenko, Oksana; Khussainova, Elmira; Dubrova, Yuri E.

doi:10.1080/09553002.2020.1711460

Cited by 6 publications

(5 citation statements)

References 42 publications

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“…In the present study, considering entirely the studied cohort, a mean frequency of Dic + CR of 0.84 (±0.83) per 1000 cells was found. This value is very similar to other published data on Kazakhstan control subjects reported in previous studies ( Table 3 ) [ 19 , 22 , 23 , 26 , 27 , 33 ]. In particular, a mean dicentric frequency of 0.71‰ was found in a group of control subjects from Kurchatov in northeast Kazakhstan [ 19 ], while a dicentric frequency of 0.78‰ was found in a group of controls from Kokpekty in East Kazakhstan [ 27 ].…”

Section: Discussionsupporting

confidence: 92%

“…Since 2018, Kazakhstan has been a member of the ARADOS (Asian Network of Biological Dosimetry) network [ 18 ], which is a platform for radiation dosimetry research among Asian countries. In addition, Kazakhstan has participated in many epidemiological studies using biological dosimetry techniques such as dicentrics, FISH translocations and physical dosimetry methods [ 19 , 20 , 21 , 22 , 23 ] as well as research on the biological effects of radiation on the human body, which further confirms the importance of research in this direction [ 24 ].…”

Section: Introductionmentioning

confidence: 97%

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Background Level of Unstable Chromosome Aberrations in the Kazakhstan Population: A Human Biomonitoring Study

Kenzhina

Mamyrbayeva

Лукашенко

et al. 2022

IJERPH

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Kazakhstan is known as a country with a complex radioecological situation resulting from different sources such as a natural radiation background, extensive activities of the industrial system of the former Soviet Union and a well-known testing of nuclear power weapons occurred in the Semipalatinsk Test Site (STS) area. The present study focuses on the assessment of the background of dicentric chromosomes in Kazakhstan’s population, which is the starting point in the dose assessment of irradiated people, since the baseline level of spontaneous dicentrics can vary significantly in different populations. In this context, aiming to determine the background frequency of chromosome aberrations in the population of Kazakhstan, considering the heterogeneity of natural radiation background levels of its large territory, a selection of 40 control subjects living in four cities of North, South, West and East Kazakhstan was performed. The cytogenetic study on the selected groups showed fairly low background frequency values of chromosome aberrations (0.84 ± 0.83 per 1000 cells), comparable with other data in the literature on general populations, reporting background frequency values between 0.54 and 2.99 per 1000 cells. The obtained results should be taken into account when constructing the dose–effect calibration curve used in cytogenetic biodosimetry, as a “zero” dose point, which will reduce the uncertainty in quantifying the individual absorbed dose in emergency radiological situations.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 97%

Background Level of Unstable Chromosome Aberrations in the Kazakhstan Population: A Human Biomonitoring Study

Kenzhina

Mamyrbayeva

Лукашенко

et al. 2022

IJERPH

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“…An increase of diseases level of the musculoskeletal system, endocrine system and digestive organs has been shown (Aleshina, 2020). Other studies have described changes caused by 137 Cs in metabolism, immune and reproductive functions (Manens et al, 2016), as well as at the level of the genetic apparatus and cellular anomalies (Djansugurova et al, 2020; Romanenko et al, 2022). Thus, the studied topic will be relevant for a very long time and requires monitoring of both food and public health, because it is required to create models of chronic exposure of radio emission on animal and public health, which significantly differ from acute exposure (Kesäniemi et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

The quality of beef in the conditions of the former Semipalatinsk Test Site

Duyssembayev

Serikova

Ikimbayeva

et al. 2023

Animal Physiology Nutrition

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The territory of the Semipalatinsk Nuclear Test Site represents vast areas of grassy steppes, their use as pastures seems promising. The purpose of work was to compare beef samples obtained from settlements belonging to different categories of radiation risk: Kokpekty village, Chagan urban‐type settlement, Krivinka village, Sarzhal village, three samples were examined from each settlement. Organoleptic analysis, radiometric determination of 137Cs, was used as criteria. Also, an analysis of the amino acid composition by the high‐performance liquid chromatograph method was carried out and a calculation of protein indicators was made: meat tenderness, amino acid usefulness, nutrition value. The organoleptic examination showed the compliance of all samples with the standards, with the exception of one sample from the Sarzhal village. The study of the specific activity of 137Cs showed a direct correlation between the category of radiation risk and the content of this radioisotope in meat from different zones. The availability of some deviations in the samples indicators obtained from the Sarzhal village indicates the need to approach the products control from this zone more carefully, and radioisotope analysis should become a decisive criterion in determining the safety profile of the product.

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“…Several topics could be candidates for future research, assuming that relevant data could be obtained. First, chromosome aberration frequency following radiation exposure might be affected by genetic factors, such as DNA repair gene polymorphisms (Djansugurova et al 2020 ). We did not attempt to measure or adjust for any genetic factors as the blood samples were collected in the past for another purpose and informed consent was not obtained for genetic analysis.…”

Section: Discussionmentioning

confidence: 99%

Chromosome aberrations among atomic-bomb survivors exposed in utero: updated analysis accounting for revised radiation doses and smoking

Cologne

Sugiyama

Hamasaki

et al. 2022

Radiat Environ Biophys

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A previous study of peripheral blood lymphocyte translocations around age 40 among atomic-bomb survivors exposed in utero revealed no overall association with radiation dose—despite a clear association between translocations and dose among their mothers—but the data suggested an increase at doses below 100 mGy with a definite peak. That analysis of the in utero-exposed survivors did not adjust for their subsequent smoking behavior, an established cause of chromosomal aberrations, or their subsequent exposures to medical irradiation, a potential mediator. In addition, atomic-bomb survivor radiation dose estimates have subsequently been updated and refined. We therefore re-estimated the dose response using the latest DS02R1 dose estimates and adjusting for smoking as well as for city and proximal–distal location at the time of exposure to the atomic bomb. Sex of the survivor, mother’s age around the time of conception, and approximate trimester of gestation at the time of exposure were also considered as explanatory variables and modifiers. Precision of the estimated dose response was slightly lower due to greater variability near zero in the updated dose estimates, but there was little change in evidence of a low-dose increase and still no suggestion of an overall increase across the entire dose range. Adjustment for smoking behavior led to a decline in background number of translocations (the dose–response intercept), but smoking did not interact with dose overall (across the entire dose range). Adjustment for medical irradiation did not alter the association between dose and translocation frequency. Sex, mother’s age, and trimester were not associated with number of translocations, nor did they interact with dose overall. Interactions with dose in the low-dose range could not be evaluated because of numerical instability.

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The effects of DNA repair polymorphisms on chromosome aberrations in the population of Kazakhstan

Cited by 6 publications

References 42 publications

Background Level of Unstable Chromosome Aberrations in the Kazakhstan Population: A Human Biomonitoring Study

Background Level of Unstable Chromosome Aberrations in the Kazakhstan Population: A Human Biomonitoring Study

The quality of beef in the conditions of the former Semipalatinsk Test Site

Chromosome aberrations among atomic-bomb survivors exposed in utero: updated analysis accounting for revised radiation doses and smoking

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