2020
DOI: 10.3390/ijms21030806
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The Effects of Early-Onset Pre-Eclampsia on Placental Creatine Metabolism in the Third Trimester

Abstract: Creatine is a metabolite important for cellular energy homeostasis as it provides spatio-temporal adenosine triphosphate (ATP) buffering for cells with fluctuating energy demands. Here, we examined whether placental creatine metabolism was altered in cases of early-onset pre-eclampsia (PE), a condition known to cause placental metabolic dysfunction. We studied third trimester human placentae collected between 27–40 weeks’ gestation from women with early-onset PE (n = 20) and gestation-matched normotensive cont… Show more

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Cited by 16 publications
(12 citation statements)
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“…The same kidney damage in PE that causes PRO may damage the ability of the kidneys to produce sufficient creatine, and, therefore, the increased placental expression levels of GATM could be a consequence of kidney damage having occurred. 47,49 Signaling pathways are the predominant pathways enriched for in the PPINs…”
Section: Pe and Pro Converge At The Pathway Level But Not The Genetic...mentioning
confidence: 99%
“…The same kidney damage in PE that causes PRO may damage the ability of the kidneys to produce sufficient creatine, and, therefore, the increased placental expression levels of GATM could be a consequence of kidney damage having occurred. 47,49 Signaling pathways are the predominant pathways enriched for in the PPINs…”
Section: Pe and Pro Converge At The Pathway Level But Not The Genetic...mentioning
confidence: 99%
“…Similarly, in PE placentae, total creatine content has been reported to increase by 38%, with GATM , GAMT , SLC6A8 and CKBB mRNA expression also significantly increased compared to gestational age-matched controls, although, again, these differences were not observed at a protein level [ 14 ]. There is evidence that, in the case of PE, this additional creatine may be transported to the compromised fetus, with a recent study by Jääskeläinen et al (2018) reporting an increase in creatine concentration in venous cord plasma from PE pregnancies [ 71 ].…”
Section: Creatine Metabolism In the Human Placentamentioning
confidence: 99%
“…Some interesting correlations were also observed in healthy control placentae throughout these collective retrospective studies, with placental GATM mRNA expression and GAA tissue content decreasing with advancing gestational age and birth weight. These adaptations associated with placental senescence were not observed in FGR or PE placentae, indicating an ongoing reliance on the creatine kinase circuit for placental bioenergetics in compromised pregnancies [ 13 , 14 ]. It is interesting to note that GATM , the gene that expresses AGAT, has been identified as a maternally imprinted gene, and thus is exclusively expressed in placental tissue from the maternal allele [ 72 ].…”
Section: Creatine Metabolism In the Human Placentamentioning
confidence: 99%
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“…It is a fascinating journey through the complex world of science, all meant to add another piece to the picture. The original papers range from new technologies for identifying changes in the maternal system to putative new therapies, the effect of the syndrome on the placenta, rodent models of preeclampsia, effects of the syndrome on the cardiovascular system, sex-specific differences and the effect on the children born from a preeclamptic pregnancy [ 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 ]. The reviews of this Special Issue range from immunoregulation and macrophages during preeclampsia and molecular targets of therapeutics to trophoblast invasion, uterine blood flow and angiogenesis, they touch on specific protein families and oxidative stress related to preeclampsia, and finally deal with autophagy in preeclampsia and the role of epigenetics in the etiology of the syndrome [ 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 ].…”
mentioning
confidence: 99%