The effects of early- or mid-gestation nutrient restriction on bovine fetal pancreatic development

McCarty, Kathleen M.; Washburn, J.L.; Taylor, R.K.; Long, N. M.

doi:10.1016/j.domaniend.2019.07.005

Cited by 11 publications

(8 citation statements)

References 25 publications

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“…Os mesmos autores afirmam que estas mudanças estruturais e funcionais dos órgãos servem para permitir uma rápida adaptação do feto em desenvolvimento à pressão de seleção ambiental uterina. A restrição de nutrientes para o feto durante a gestação precoce ou média pode afetar negativamente o desenvolvimento do pâncreas fetal (McCarty et al, 2020). Em complemento, Maresca et al (2018) observaram que bezerros nascidos de vacas com baixa ingestão de proteína durante a metade final de gestação eram hiperglicêmicos durante os primeiros 60 dias de vida, aspecto que limita o desempenho destes animais em sistemas mais intensivos de produção.…”

Section: Discussionunclassified

Efeito do histórico reprodutivo da vaca sobre o desempenho da progênie

Klein

Brondani

Filho

et al. 2021

RSD

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A condição nutricional e fisiológica da vaca durante a gestação tem sido associada com a formação fetal e desempenho futuro da progênie. O objetivo do trabalho foi avaliar os efeitos do histórico da vaca gestante sobre o desempenho da progênie. Foram utilizadas 343 vacas de corte Charolês e Nelore, sendo divididas conforme o histórico reprodutivo: vacas prenhas que repetiram prenhez (P); vacas vazias que emprenharam (V). Os dados foram coletados durante 5 anos no rebanho experimental. Vacas V apresentaram maior escore de condição corporal (ECC) (2,83 vs 3,05 pontos) e peso corporal ao final da estação reprodutiva (462,72 vs 478,82 kg), além de menor ECC ao parto (2,58 vs 2,64 pontos) e maior perda de peso durante a gestação (-35,17 vs -13,34 kg) em comparação às vacas P. O peso ajustado aos 205 dias de idade foi maior na progênie de vacas P (140,54 vs 139,35 kg), sem efeitos aos 365 e 540 dias (P>0,05). O desempenho aos 7 meses de idade foi maior na progênie de vacas P (0,517 vs 0,502 kg/dia), enquanto que a progênie de vacas V foi superior aos 12 e aos 18 meses de idade, com valores respectivamente de 0,558 vs 0,397 e 0,379 vs 0,351 kg/dia. Bezerros de vacas P apresentaram maior valor de Kleiber aos 7 meses, enquanto que a progênie de vacas V foi mais eficiente aos 12 meses. O histórico reprodutivo da vaca influencia o desempenho da progênie, onde vacas vazias produzem bezerros com maior potencial produtivo na vida adulta.

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Section: Discussionunclassified

Efeito do histórico reprodutivo da vaca sobre o desempenho da progênie

Klein

Brondani

Filho

et al. 2021

RSD

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“…Experimentally induced intrauterine growth retardation in rats resulted in alterations of the endocrine pancreas, reduced pancreatic weight and β cell mass at birth, and lower insulin secretion in adult life. Similarly reduced fetal pancreatic β cell mass and increased β cell apoptosis have been observed in bovine fetuses that have been exposed to maternal nutrient restriction [ 46 ]. In our study, calves born from 15 M dams had reduced glucose during the first 98 days of life, and calves born from 27 M dams had reduced glucose during the first 55 days of life compared to calves from adult cows.…”

Section: Discussionmentioning

confidence: 92%

Age at First Gestation in Beef Heifers Affects Fetal and Postnatal Growth, Glucose Metabolism and IGF1 Concentration

Valiente

Rodríguez

Long

et al. 2021

Animals

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This study aimed to determine the effects of age at first gestation on offspring growth performance, glucose metabolism, and IGF1 concentration. Heifers impregnated by AI from a single bull at 15 months of age (15 M, n = 20), or 27 months of age (27 M, n = 20), and multiparous cows (adult, n = 20) were used. Dams from all groups were managed in a single group during gestation and lactation. Gestational length was longer in the 15 M and 27 M than in adult dams (p = 0.009). Bodyweight at birth, at weaning and ADG during lactation were higher in calves from adult dams than in those from 27 M dams, and higher in calves from the latter than in 15 M calves (p < 0.001). Calves from 15 M dams had an increased head circumference/BW ratio compared to calves from 27 M dams, while calves from this latter group had an increased ratio compared to calves from adults (p = 0.005). Body mass index was greater in calves from adults than in those from 15 M and 27 M dams (p = 0.002). Milk production from 15 M and 27 M dams was similar but lower than that from adults (p = 0.03). Calves born from adult dams had greater blood glucose concentrations than those from 15 M and 27 M dams (p < 0.05). Serum IGF1 concentrations were higher in calves from adults than in calves from 15 M and 27 M dams (p = 0.01). This study showed that age at first gestation affects offspring postnatal growth performance, glucose metabolism and IGF1 concentration.

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“…In this case, according to Greenwood, Thompsom and Ford (2010), the animal exhibits greater metabolic adaptation capacity to less favorable environments during postnatal life, which may result in greater weight gains than animals with better fetal formation. This greater adaptation capacity may result from alterations in liver and pancreas homeostatic mechanisms, which influence the ability of the progeny to metabolize nutrients (Keomanivong et al, 2016;McCarty, Washburn, Taylor, & Long, 2020).…”

Section: Resultsmentioning

confidence: 99%

Beef cow weight variations during gestation and offspring performance: a meta-analysis

Klein¹,

Machado²,

Adams³

et al. 2021

Semina: Ciênc. Agrár.

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The objective of this meta-analysis was to evaluate the effects of weight loss or weight gain of beef cows during the second and/or third trimester of gestation on the postnatal performance of the progeny. The variation in cow weight during the gestational period was calculated to standardize the treatments, being them: severe loss (SL = cows that lost more than 10% of weight); moderate loss (ML = cows that lost from 0 to 10% of weight) and weight gain (WG = cows that gained weight). The intensity of the cow weight variation effect was calculated as the mean difference (MD) with a 95% confidence interval and heterogeneity determined using the Q test and the I2 statistic. A meta-analysis of random effects was conducted for each indicator separately with the means of the control and experimental groups. Calves from WG cows were higher for birth weight (P = 0.0094); weight adjusted to 205 days (P = 0.0127) and average daily gain during pre-weaning (P < 0.0001) in relation to calves from ML cows. The W205 of calves from SL cows was 11.6 kg lower than the progeny from ML cows. The post-weaning performance of the progeny tended (P = 0.0868) to be higher in the progeny of WG cows than ML ones. The weight gain of beef cows during gestation improves the pre- and post-weaning performance of the progeny, with more evident effects in the early months of life of the offspring.

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The effects of early- or mid-gestation nutrient restriction on bovine fetal pancreatic development

Cited by 11 publications

References 25 publications

Efeito do histórico reprodutivo da vaca sobre o desempenho da progênie

Efeito do histórico reprodutivo da vaca sobre o desempenho da progênie

Age at First Gestation in Beef Heifers Affects Fetal and Postnatal Growth, Glucose Metabolism and IGF1 Concentration

Beef cow weight variations during gestation and offspring performance: a meta-analysis

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