The Effects of Eating and of Sham Feeding Upon the Absorption of Vitamin a Palmitate in Man 1

Mendeloff, Albert I.

doi:10.1172/jci102968

Cited by 44 publications

(26 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, this phenomenon has been shown to reflect rapid entry into the blood of chylomicrons containing fat from the first meal (Fielding, B. A. et al 1995), consistent with Mendeloff's (1954) proposal. Rates of fat absorption are also known to be influenced by macronutrient composition and apparently by subtle cues related to taste and smell (Bergeron & Havel, 1997).…”

Section: Intestinal and Hepatic Contributions To Postprandial Lipaemisupporting

confidence: 74%

Postprandial lipid metabolism: an overview

Havel

1997

Proc. Nutr. Soc.

View full text Add to dashboard Cite

Since the original investigations of Gage & Fish (1 924) on the dynamics of large chylomicron particles during postprandial lipaemia, measurements of triacylglycerol-rich lipoproteins (TRL) after ingestion of fat-rich meals have been utilized to provide information about the metabolism of these intestinal lipoprotein particles in vivo. There are many similarities, however, between the metabolism of chylomicrons and hepatogenous VLDL (Havel, 1989), so that observations in the postprandial state may provide generally applicable information about the regulation of TRL metabolism. Recently, it has become possible to distinguish the dynamics of chylomicron and VLDL particles separately by analysing the fluctuations of the concentrations of the two forms of apolipoprotein (apo) B with which they are associated B-48 and B-100 respectively (Havel, 1994).The overall pathway of absorption of dietary lipids has long been known and the rapid clearance and metabolism of chylomicron triacylglycerols was appreciated early in this century. The modern era of research in this area, however, had to await the development of methods to separate and characterize plasma lipoproteins (Gofman et al. 1949; Havel et af. 1955) and was greatly stimulated by the discovery of lipoprotein lipase (EC 3.1.1.34; Korn, 1955) and the demonstration that genetic deficiency of this enzyme dramatically reduces the rate of clearance of dietary fat from the blood (Havel & Gordon, 1960). Related physiological studies showed that chylomicron triacylglycerols are rapidly hydrolysed and that their products, free fatty acids (FFA), are concomitantly released and transported in the blood bound to albumin (Havel & Fredrickson, 1956). DELINEATION OF THE CHYLOMICRON PATHWAYEarly studies of postprandial lipaemia in normal adults showed that all the major lipids of TRL rise and fall together with triacylglycerols (Havel, 1957). These studies also showed that HDL-lipids are affected by fat ingestion, and that HDL-phospholipid concentrations in particular are substantially increased (Havel, 1957; Havel et af. 19736). Subsequent studies in animals showed that the metabolism of the second major core component of chylomicrons, cholesteryl esters, differs dramatically from that of triacylglycerols, and led to a two-step model of chylomicron metabolism. In hepatectomized dogs, clearance from the blood of cholesteryl esters of chylomicrons but not triacylglycerols, was substantially impeded (Nestel et al. 1963). Furthermore, the majority of triacylglycerolfatty acids from chylomicrons were taken up by extrahepatic tissues, whereas component cholesteryl esters were removed almost quantitatively by the liver (Bergman et al. 1971). The liver also took up 10-20 % of intact chylomicron triacylglycerols in dogs and sheep as well as about one-fifth of the chylomicron triacy lglycerol-fatty acids released in extrahepatic tissues by the action of lipoprotein lipase on chylomicron triacylglycerols (Bergman et al. 1971). These and other studies in several mammalian species (Redgrav...

show abstract

Section: Intestinal and Hepatic Contributions To Postprandial Lipaemisupporting

confidence: 74%

Postprandial lipid metabolism: an overview

Havel

1997

Proc. Nutr. Soc.

View full text Add to dashboard Cite

show abstract

“…Although the sensory experience of fat can lead to serious food addiction and health problems, its intended role is to guide appropriate food selection and also to enhance digestion. The role of neural input from taste receptors in the digestive process was probably first demonstrated in a study with subjects that failed to show absorption of vitamin A palmitate, which was published in the JCI in 1954 (16). The author of the study, Mendeloff, stated that, surprisingly, the thought or act of eating appeared to activate mechanisms that markedly increase fat absorption.…”

Section: Why Do We Like Fat?mentioning

confidence: 99%

“…The author of the study, Mendeloff, stated that, surprisingly, the thought or act of eating appeared to activate mechanisms that markedly increase fat absorption. His conclusion was based on the observation that sham feeding, which involved mastication of a palatable meal without swallowing any of it, was associated with an immediate increase in blood levels of vitamin A palmitate given 2 hours earlier (16). Subsequent studies have extended these observations and further demonstrated that orosensation contributes to enhancing fat absorption and to a faster appearance of absorbed products in the blood (17).…”

Section: Why Do We Like Fat?mentioning

confidence: 99%

CD36 may determine our desire for dietary fats

Abumrad

2005

Journal of Clinical Investigation

View full text Add to dashboard Cite

“…Accumulating evidence suggests this may be initiated by a sensory property of the foods [6,7,8]. Sham feeding (which provides sensory stimulation without ingestion) a palatable meal several hours after ingestion of an retinal ester oil emulsion leads to an immediate increase in plasma retinal ester concentration suggesting an orosensory influence on lipid absorption [9]. More recent work indicates the sensory cue is a dietary fat.…”

Section: Introductionmentioning

confidence: 99%